DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Crtc and Crtc1

DIOPT Version :9

Sequence 1:	NP_001261997.1	Gene:	Crtc / 39970	FlyBaseID:	FBgn0036746	Length:	889	Species:	Drosophila melanogaster
Sequence 2:	NP_001040580.1	Gene:	Crtc1 / 684527	RGDID:	1589158	Length:	630	Species:	Rattus norvegicus

Alignment Length:	877	Identity:	197/877 - (22%)
Similarity:	282/877 - (32%)	Gaps:	338/877 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 NPRKFSEKIALQKQKQAEGTAEFERIMKEVYATK--RDEPPANQKILDGLVGGQEVSQSSPGAGN 65
            |||||||||||..|||||.||.||.:||::..|:  |.:...:|.:           |..|..|.
  Rat     6 NPRKFSEKIALHNQKQAEETAAFEEVMKDLSLTRAARLQLQKSQYL-----------QLGPSRGQ 59

  Fly    66 GTGGG-------GSGSGSGASGGGASPDGLGGG------GGSPTAYRESRGRSVGVGPMRRPSE- 116
            ..||.       ||.|...:........||...      |.....||| ||| :| .|.|||..
  Rat    60 YYGGSLPNVNQIGSSSMDLSFQTPFQSSGLDTSRTTRHHGLVDRVYRE-RGR-LG-SPHRRPLSV 121

  Fly   117 ----RKQDRSPYGSSSTQQTLDNGQLNPHLLGPPTAESLWRRSSSDSALHQSALVAGFNSDVNSM 177
                |:.|..|||:.              .|.|| |::.|||::||||||||.:..   :...|.
  Rat   122 DKHGRQADSCPYGTV--------------YLSPP-ADTSWRRTNSDSALHQSTMTP---TQAESF 168

  Fly   178 GANYQQQQHQQQ----QQPGQPRSHSPHHGINRTMSPQAQRRKSPLLQPHQLQLQQLQQQQQQMQ 238
            ... .|..||::    ..||...:.|.   .::|:|.|:...|....:|...::..:.
  Rat   169 TGG-PQDAHQKRVLLLTVPGMEETGSE---TDKTLSKQSWDSKKAGSRPKSCEVPGIN------- 222

  Fly   239 HQHQLHQQLQMQQLQQHQQQHQQQQQQQNTPYNNAKFTNPVFRPLQDQVNFA-------NT-GSL 295
                                                    :| |..||.|.|       || |||
  Rat   223 ----------------------------------------IF-PSADQENTAALIPATHNTGGSL 246

  Fly   296 PDLTALQNYGPQQQQQQSQQQPSQQQQQLQQTLSPVMSPHNHRRERDQSPSPFSPAGGGGGAGPG 360
            |||:.:....|                 |...|.|...|.........:.|......||.|.|..
  Rat   247 PDLSTIHFPSP-----------------LPTPLDPEEPPFPALTSSGSTGSLAHLGVGGTGQGMN 294

  Fly   361 SPYQQQQHSP------TGNTQQQQQQHQQ--PSNSPHLSFTNLATTQAAVTTFNPLPTLGPHNAT 417
            :|....|..|      :.:|:.::||.||  |:.|| ||....|....|::....||......|.
  Rat   295 TPSSSPQRRPAVVSPLSLSTEARRQQAQQVPPTLSP-LSPITQAVAMDALSLEQQLPYAFFTQAG 358

  Fly   418 DYRQPPNPPSPRSSPGLLSSVSATDLHSSAPASPIRQQQQAHQQQQQQQQAQQQQQQFDNSYNSL 482
            ..:.||.|..|                  .|..|:.|||....|
  Rat   359 SQQPPPQPQPP------------------PPPPPVSQQQPPPPQ--------------------- 384

  Fly   483 NTSFHNQFEIFSLGDSNSSPEQQGFANNFVALDFDDLSGGGGGGPSGGGGSNGGGLTNGYNKPEM 547
                                         |::          |.|.||.......||.|...|.:
  Rat   385 -----------------------------VSV----------GLPQGGPLLPSASLTRGPQLPPL 410

  Fly   548 LDF--SELSGSPEASGNNNHMRRGVSNLNNNGLSNGVVGSTHNGSTNLNGAGNNNSSSGGGTAQD 610
            ...  |.|..||..|                                              ..|.
  Rat   411 AVTVPSTLPQSPTES----------------------------------------------PGQP 429

  Fly   611 PLGITTSPVP-----SPLGCPSSPLPIPIPMSAQ-----SSPQQ---------QHHHHQQQQQQH 656
            |:||..:..|     :..|.|::..|.. |:|.|     ||||.         ..::.||...:.
  Rat   430 PMGIDVTSAPALQYRTGAGSPATQSPTS-PVSNQGFSPGSSPQHTSTLGSVFGDAYYEQQMTARQ 493

  Fly   657 HQQQHHQQQQLSLSLHHSPHHSPMHSPHHGNSPLSSSSPVSHNACSNSNVVMNH--QQQQQQHHH 719
            ......|.:|.:: :.::...|.:::|         .|.::::..:...:..:|  .|..||..:
  Rat   494 ANALSRQLEQFNM-MENAISSSSLYNP---------GSTLNYSQAAMMGLSGSHGGLQDPQQLGY 548

  Fly   720 QQHHHQGSSQSHTPTTANIPSIIF---------------------SDYSSNADYTREIFDSLDLD 763
            ..|             ..||:||.                     ||.|.::|:...: |.|.:|
  Rat   549 AGH-------------GGIPNIILTVTGESPPSLSKELSSTLAGVSDVSFDSDHQFPL-DELKID 599

  Fly   764 LGQMDVAGLQMLSDQNPIMIADPNIEDSFRRD 795
            ...:|  ||.||:|.: :::|||..||:||.|
  Rat   600 PLTLD--GLHMLNDPD-MVLADPATEDTFRMD 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Crtc	NP_001261997.1	TORC_N	3..61	CDD:289639	26/59 (44%)
Crtc	NP_001261997.1	TORC_C	739..795	CDD:289641	23/76 (30%)
Crtc1	NP_001040580.1	TORC_N	6..66	CDD:403936	30/70 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	142..174		13/35 (37%)
		TORC_M	148..289	CDD:403937	42/212 (20%)
		PTZ00449	<170..470	CDD:185628	89/494 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	187..221		7/36 (19%)
		Nuclear export signal. /evidence=ECO:0000250	242..258		8/32 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	256..331		21/92 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	356..475		40/243 (16%)
		TORC_C	555..630	CDD:403938	24/78 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353577
Domainoid	1	1.000	51	1.000	Domainoid score	I11278
eggNOG	1	0.900	-	-		E1_28MKB
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	91	1.000	Inparanoid score	I5012
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001294
OrthoInspector	1	1.000	-	-		oto97003
orthoMCL	1	0.900	-	-		OOG6_107546
Panther	1	1.100	-	-	LDO	PTHR13589
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1320
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.880