DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Crtc and CRTC3

DIOPT Version :9

Sequence 1:	NP_001261997.1	Gene:	Crtc / 39970	FlyBaseID:	FBgn0036746	Length:	889	Species:	Drosophila melanogaster
Sequence 2:	NP_073606.3	Gene:	CRTC3 / 64784	HGNCID:	26148	Length:	619	Species:	Homo sapiens

Alignment Length:	894	Identity:	184/894 - (20%)
Similarity:	266/894 - (29%)	Gaps:	386/894 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ANPRKFSEKIALQKQKQAEGTAEFERIMKEVYATKRDEPPANQKILDGLVGGQ--EVSQSSPGAG 64
            ||||||||||||..|:|||.|..||::|.::..::.......|..|....||.  .|||.
Human    10 ANPRKFSEKIALHTQRQAEETRAFEQLMTDLTLSRVQFQKLQQLRLTQYHGGSLPNVSQL----- 69

  Fly    65 NGTGGGGSGSGSGASGGGASPDGLGGGGGSPTAYRESRGRSVGVGPMRRPS----ERKQDRSPYG 125
                   ..|.|.........|.:.|........|.||.|   ..|:.|.|    .|:.|.|.:|
Human    70 -------RSSASEFQPSFHQADNVRGTRHHGLVERPSRNR---FHPLHRRSGDKPGRQFDGSAFG 124

  Fly   126 SSSTQQTLDNGQLNPHLLGPPTAESLWR--------------RSSSDSALHQSALVAGFNSDVNS 176
            ::.:.|.||...        |..:..|:              |::||||||.|||
Human   125 ANYSSQPLDESW--------PRQQPPWKDEKHPGFRLTSALNRTNSDSALHTSAL---------- 171

  Fly   177 MGANYQQQQHQQQQQP----GQPRSHSPHHGINRTMSPQAQRRKSPLLQPHQLQLQQLQQQQQQM 237
                     ..:.|.|    ||....:|:.|.                                .
Human   172 ---------STKPQDPYGGGGQSAWPAPYMGF--------------------------------C 195

  Fly   238 QHQHQLHQQLQMQQLQQHQQQHQQQQQQQNTPYNNAKFTNPVFRPLQDQVNFANTGSLPDLTALQ 302
            ..::..|.::                         |.|..|:     .:.|..|.
Human   196 DGENNGHGEV-------------------------ASFPGPL-----KEENLLNV---------- 220

  Fly   303 NYGPQQQQQQSQQQPSQQQQQLQQTLSPVMSPHNHRRERDQSPSPFSPAGGGGGAGPGSPYQQQQ 367
                          |....:||.:|          :..:..|..|.|...|||.|.|
Human   221 --------------PKPLPKQLWET----------KEIQSLSGRPRSCDVGGGNAFP-------- 253

  Fly   368 HSPTGNTQQQQQQHQQPSNSPHLSFTNLATTQAAVTTFNPLPTLGPHNATDYRQPPNPPSPRSSP 432
                       ...|....||.|...|         |...||.|
Human   254 -----------HNGQNLGLSPFLGTLN---------TGGSLPDL--------------------- 277

  Fly   433 GLLSSVSATDLHSSAPASPIRQQQQAHQQQQQQQQAQQQQQQFDNSYNSLNTSFHNQFEIFSLGD 497
                    |:||.|.|...                             ||:|:.|: |...|:|:
Human   278 --------TNLHYSTPLPA-----------------------------SLDTTDHH-FGSMSVGN 304

  Fly   498 SNSSPEQQGFANNFVALDFDDLSGGGGGGPSGGGGSNGGGLTNGYNKPEMLDFSELSGSPEASGN 562
            |         .||..|            ..:..|..:..||.:..:.|.:.  :.|:.:..:|..
Human   305 S---------VNNIPA------------AMTHLGIRSSSGLQSSRSNPSIQ--ATLNKTVLSSSL 346

  Fly   563 NNHMRRGVSN------------LNNNGLSNGVVGSTHNGSTNLNGAGNNNSSSGGGTAQDPLG-I 614
            |||.:..|.|            |:|..||          :|||:|.....        |.|:. :
Human   347 NNHPQTSVPNASALHPSLRLFSLSNPSLS----------TTNLSGPSRRR--------QPPVSPL 393

  Fly   615 TTSPVP-------------SPLGCPSSPLP--------------IPIPMSAQSSPQQQHHHHQQQ 652
            |.||.|             |||    :|.|              :|....||.||...:...|:.
Human   394 TLSPGPEAHQGFSRQLSSTSPL----APYPTSQMVSSDRSQLSFLPTEAQAQVSPPPPYPAPQEL 454

  Fly   653 QQQHHQQQH-----HQQQQLSLSLHHSPHHSPMHSPHHGNSPLSSSSPVSHNACSNSNVVMNHQ- 711
            .|...||..     .||.|.:.||   |.......|..|:| |::..|         :|..:.|
Human   455 TQPLLQQPRAPEAPAQQPQAASSL---PQSDFQLLPAQGSS-LTNFFP---------DVGFDQQS 506

  Fly   712 --------------QQQQQHHHQQHHHQGSSQSHTPTTAN--IP----SIIFSDYSS-------- 748
                          ||..:......|.:.|..|:..:..|  :|    :.:|.|.:|
Human   507 MRPGPAFPQQVPLVQQGSRELQDSFHLRPSPYSNCGSLPNTILPEDSSTSLFKDLNSALAGLPEV 571

  Fly   749 --NADYTREIFDSLDLDLGQMDVAGLQMLSDQNPIMIADPNIEDSFRRD 795
              |.|....:.:.|.::...:|  ||.||||.: :.:.||::|::||.|
Human   572 SLNVDTPFPLEEELQIEPLSLD--GLNMLSDSS-MGLLDPSVEETFRAD 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Crtc	NP_001261997.1	TORC_N	3..61	CDD:289639	26/59 (44%)
Crtc	NP_001261997.1	TORC_C	739..795	CDD:289641	19/69 (28%)
CRTC3	NP_073606.3	Required for interaction with HTLV-1 TAX	1..103		35/107 (33%)
		TORC_N	11..64	CDD:403936	23/52 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	103..150		12/54 (22%)
		TORC_M	159..319	CDD:403937	60/382 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	165..185		9/38 (24%)
		PHA03378	<346..537	CDD:223065	49/225 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	375..431		16/77 (21%)
		Required for interaction with PPP2CA and PPP2R1A. /evidence=ECO:0000250\|UniProtKB:Q91X84	380..401		7/28 (25%)
		TORC_C	545..619	CDD:403938	21/76 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159531
Domainoid	1	1.000	51	1.000	Domainoid score	I11587
eggNOG	1	0.900	-	-		E1_28MKB
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	77	1.000	Inparanoid score	I5257
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001294
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13589
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1320
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.980