Protein Alignment Crtc and Crtc1

DIOPT Version :10

• Sequence 1: NP_001261997.1
• Gene: Crtc / 39970
• FlyBaseID: FBgn0036746
• Length: 889
• Species: Drosophila melanogaster
• Sequence 2: NP_001391344.1
• Gene: Crtc1 / 382056
• MGIID: 2142523
• Length: 657
• Species: Mus musculus
• Alignment Length: 875
• Identity: 202/875 - (23%)
• Similarity: 289/875 - (33%)
• Gaps: 307/875 - (35%)

  Fly     3 NPRKFSEKIALQKQKQAEGTAEFERIMKEVYATK--RDEPPANQKILDGLVGGQEVSQSSPGAGN 65
            |||||||||||..|||||.||.||.:||::..|:  |.:...:|.:           |..|..|.
Mouse     6 NPRKFSEKIALHNQKQAEETAAFEEVMKDLSLTRAARLQLQKSQYL-----------QLGPSRGQ 59

  Fly    66 GTGGG-------GSGSGSGASGGGASPDGLGGG------GGSPTAYRESRGRSVGVGPMRRPSE- 116
            ..||.       ||.|...|........||...      |.....||| ||| :| .|.|||..
Mouse    60 YYGGSLPNVNQIGSSSVDLAFQTPFQSSGLDTSRTTRHHGLVDRVYRE-RGR-LG-SPHRRPLSV 121

  Fly   117 ----RKQDRSPYGSSSTQQTLDNGQLNPHLLGPPTAESLWRRSSSDSALHQSALVAGFNSDVNSM 177
                |:.|..|||:.              .|.|| |::.|||::||||||||.:..   |...|.
Mouse   122 DKHGRQADSCPYGTV--------------YLSPP-ADTSWRRTNSDSALHQSTMTP---SQAESF 168

  Fly   178 GANYQQQQHQQQ----QQPGQPRSHSPHHGINRTMSPQAQRRKSPLLQPHQLQLQQLQQQQQQMQ 238
            ... .|..||::    ..||...:.:.   .::|:|.|:...|....:|...::..:  ....:.
Mouse   169 TGG-SQDAHQKRVLLLTVPGMEDTGAE---TDKTLSKQSWDSKKAGSRPKSCEVPGI--NCPGLA 227

  Fly   239 HQHQLHQQLQMQQLQQHQQQHQQQQQQQNTPYNNAKFTNPVFRPLQDQVNFA-------NT-GSL 295
            ....|.....:.....|                   ...|...|..||.|..       || |||
Mouse   228 GLACLSLSPDLMSCPPH-------------------LVFPSIFPSADQENTTALIPATHNTGGSL 273

  Fly   296 PDLTALQNYGPQQQQQQSQQQPSQQQQQLQQTLSPVMSPHNHRRERDQSPSPFSPAGGGGGAGPG 360
            ||||.:....|                 |...|.|...|.........:.|......||.|.|..
Mouse   274 PDLTNIHFPSP-----------------LPTPLDPEEPPFPALTSSSSTGSLAHLGVGGAGQGMN 321

  Fly   361 SPYQQQQHSP------TGNTQQQQQQHQQ--PSNSPHLSFTNLATTQAAVTTFNPLPTLGPHNAT 417
            :|....||.|      :.:|:.::||.||  |:.|| ||....|....|::....|| ......|
Mouse   322 TPSSSPQHRPAVVSPLSLSTEARRQQAQQVSPTLSP-LSPITQAVAMDALSLEQQLP-YAFFTQT 384

  Fly   418 DYRQPPNPPSPRSSPGLLSSVSATDLHSSAPASPIRQQQQAHQQQQQQQQAQQQQQQFDNSYNSL 482
            ..:||  ||.|:..|               |..|:.|||....|
Mouse   385 GSQQP--PPQPQPPP---------------PPPPVSQQQPPPPQ--------------------- 411

  Fly   483 NTSFHNQFEIFSLGDSNSSPEQQGFANNFVALDFDDLSGGGGGGPSGGGGSNGGGLTNGYNKPEM 547
                                         |::          |.|.||.......||.|...|.
Mouse   412 -----------------------------VSV----------GLPQGGPLLPSASLTRGPQLPP- 436

  Fly   548 LDFSELSGSPEASGNNNHMRRGVSNLNNNGLSNGVVGSTHNGSTNLNGAGNNNSSSGGGTAQDPL 612
            |..:..|..|::...|                                           ..|.|:
Mouse   437 LSVTVPSTLPQSPTEN-------------------------------------------PGQSPM 458

  Fly   613 GITTSPVP-----SPLGCPSSPLPIPIPMSAQ-----SSPQQ---------QHHHHQQQQQQHHQ 658
            ||..:..|     :..|.|::..|.. |:|.|     ||||.         ..::.||...:...
Mouse   459 GIDATSAPALQYRTSAGSPATQSPTS-PVSNQGFSPGSSPQHTSTLGSVFGDAYYEQQMTARQAN 522

  Fly   659 QQHHQQQQLSLSLHHSPHHSPMHSPHHGNSPLSSSSPVSHNACSNSNVVMNH--QQQQQQHHHQQ 721
            ....|.:|.:: :.::...|.:::|         .|.::::..:...:..:|  .|..||..:..
Mouse   523 ALSRQLEQFNM-MENAISSSSLYNP---------GSTLNYSQAAMMGLSGSHGGLQDPQQLGYTG 577

  Fly   722 HHHQGSSQSHTPTTANIPSIIF---------------------SDYSSNADYTREIFDSLDLDLG 765
            |             ..||:||.                     ||.|.::|:...: |.|.:|..
Mouse   578 H-------------GGIPNIILTVTGESPPSLSKELSSTLAGVSDVSFDSDHQFPL-DELKIDPL 628

  Fly   766 QMDVAGLQMLSDQNPIMIADPNIEDSFRRD 795
            .:|  ||.||:|.: :::|||..||:||.|
Mouse   629 TLD--GLHMLNDPD-MVLADPATEDTFRMD 655

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Crtc	NP_001261997.1	TORC_N	3..61	CDD:463738	26/59 (44%)
		TORC_C	<761..795	CDD:463740	14/33 (42%)
Crtc1	NP_001391344.1	TORC_N	6..66	CDD:463738	30/70 (43%)
		TORC_M	148..316	CDD:463739	44/212 (21%)
		TORC_C	582..657	CDD:463740	24/78 (31%)