DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Crtc and Crtc1

DIOPT Version :9

Sequence 1:	NP_001261997.1	Gene:	Crtc / 39970	FlyBaseID:	FBgn0036746	Length:	889	Species:	Drosophila melanogaster
Sequence 2:	XP_011240613.1	Gene:	Crtc1 / 382056	MGIID:	2142523	Length:	657	Species:	Mus musculus

Alignment Length:	875	Identity:	202/875 - (23%)
Similarity:	289/875 - (33%)	Gaps:	307/875 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 NPRKFSEKIALQKQKQAEGTAEFERIMKEVYATK--RDEPPANQKILDGLVGGQEVSQSSPGAGN 65
            |||||||||||..|||||.||.||.:||::..|:  |.:...:|.:           |..|..|.
Mouse     6 NPRKFSEKIALHNQKQAEETAAFEEVMKDLSLTRAARLQLQKSQYL-----------QLGPSRGQ 59

  Fly    66 GTGGG-------GSGSGSGASGGGASPDGLGGG------GGSPTAYRESRGRSVGVGPMRRPSE- 116
            ..||.       ||.|...|........||...      |.....||| ||| :| .|.|||..
Mouse    60 YYGGSLPNVNQIGSSSVDLAFQTPFQSSGLDTSRTTRHHGLVDRVYRE-RGR-LG-SPHRRPLSV 121

  Fly   117 ----RKQDRSPYGSSSTQQTLDNGQLNPHLLGPPTAESLWRRSSSDSALHQSALVAGFNSDVNSM 177
                |:.|..|||:.              .|.|| |::.|||::||||||||.:..   |...|.
Mouse   122 DKHGRQADSCPYGTV--------------YLSPP-ADTSWRRTNSDSALHQSTMTP---SQAESF 168

  Fly   178 GANYQQQQHQQQ----QQPGQPRSHSPHHGINRTMSPQAQRRKSPLLQPHQLQLQQLQQQQQQMQ 238
            ... .|..||::    ..||...:.:.   .::|:|.|:...|....:|...::..:  ....:.
Mouse   169 TGG-SQDAHQKRVLLLTVPGMEDTGAE---TDKTLSKQSWDSKKAGSRPKSCEVPGI--NCPGLA 227

  Fly   239 HQHQLHQQLQMQQLQQHQQQHQQQQQQQNTPYNNAKFTNPVFRPLQDQVNFA-------NT-GSL 295
            ....|.....:.....|                   ...|...|..||.|..       || |||
Mouse   228 GLACLSLSPDLMSCPPH-------------------LVFPSIFPSADQENTTALIPATHNTGGSL 273

  Fly   296 PDLTALQNYGPQQQQQQSQQQPSQQQQQLQQTLSPVMSPHNHRRERDQSPSPFSPAGGGGGAGPG 360
            ||||.:....|                 |...|.|...|.........:.|......||.|.|..
Mouse   274 PDLTNIHFPSP-----------------LPTPLDPEEPPFPALTSSSSTGSLAHLGVGGAGQGMN 321

  Fly   361 SPYQQQQHSP------TGNTQQQQQQHQQ--PSNSPHLSFTNLATTQAAVTTFNPLPTLGPHNAT 417
            :|....||.|      :.:|:.::||.||  |:.|| ||....|....|::....|| ......|
Mouse   322 TPSSSPQHRPAVVSPLSLSTEARRQQAQQVSPTLSP-LSPITQAVAMDALSLEQQLP-YAFFTQT 384

  Fly   418 DYRQPPNPPSPRSSPGLLSSVSATDLHSSAPASPIRQQQQAHQQQQQQQQAQQQQQQFDNSYNSL 482
            ..:||  ||.|:..|               |..|:.|||....|
Mouse   385 GSQQP--PPQPQPPP---------------PPPPVSQQQPPPPQ--------------------- 411

  Fly   483 NTSFHNQFEIFSLGDSNSSPEQQGFANNFVALDFDDLSGGGGGGPSGGGGSNGGGLTNGYNKPEM 547
                                         |::          |.|.||.......||.|...|.
Mouse   412 -----------------------------VSV----------GLPQGGPLLPSASLTRGPQLPP- 436

  Fly   548 LDFSELSGSPEASGNNNHMRRGVSNLNNNGLSNGVVGSTHNGSTNLNGAGNNNSSSGGGTAQDPL 612
            |..:..|..|::...|                                           ..|.|:
Mouse   437 LSVTVPSTLPQSPTEN-------------------------------------------PGQSPM 458

  Fly   613 GITTSPVP-----SPLGCPSSPLPIPIPMSAQ-----SSPQQ---------QHHHHQQQQQQHHQ 658
            ||..:..|     :..|.|::..|.. |:|.|     ||||.         ..::.||...:...
Mouse   459 GIDATSAPALQYRTSAGSPATQSPTS-PVSNQGFSPGSSPQHTSTLGSVFGDAYYEQQMTARQAN 522

  Fly   659 QQHHQQQQLSLSLHHSPHHSPMHSPHHGNSPLSSSSPVSHNACSNSNVVMNH--QQQQQQHHHQQ 721
            ....|.:|.:: :.::...|.:::|         .|.::::..:...:..:|  .|..||..:..
Mouse   523 ALSRQLEQFNM-MENAISSSSLYNP---------GSTLNYSQAAMMGLSGSHGGLQDPQQLGYTG 577

  Fly   722 HHHQGSSQSHTPTTANIPSIIF---------------------SDYSSNADYTREIFDSLDLDLG 765
            |             ..||:||.                     ||.|.::|:...: |.|.:|..
Mouse   578 H-------------GGIPNIILTVTGESPPSLSKELSSTLAGVSDVSFDSDHQFPL-DELKIDPL 628

  Fly   766 QMDVAGLQMLSDQNPIMIADPNIEDSFRRD 795
            .:|  ||.||:|.: :::|||..||:||.|
Mouse   629 TLD--GLHMLNDPD-MVLADPATEDTFRMD 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Crtc	NP_001261997.1	TORC_N	3..61	CDD:289639	26/59 (44%)
Crtc	NP_001261997.1	TORC_C	739..795	CDD:289641	23/76 (30%)
Crtc1	XP_011240613.1	TORC_N	6..66	CDD:372361	30/70 (43%)
		TORC_M	148..316	CDD:372362	44/212 (21%)
		TORC_C	582..657	CDD:372363	24/78 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849902
Domainoid	1	1.000	51	1.000	Domainoid score	I11491
eggNOG	1	0.900	-	-		E1_28MKB
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	93	1.000	Inparanoid score	I5063
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001294
OrthoInspector	1	1.000	-	-		oto93463
orthoMCL	1	0.900	-	-		OOG6_107546
Panther	1	1.100	-	-	LDO	PTHR13589
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4177
SonicParanoid	1	1.000	-	-		X1320
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.910