Protein Alignment Crtc and CRTC2

DIOPT Version :9

• Sequence 1: NP_001261997.1
• Gene: Crtc / 39970
• FlyBaseID: FBgn0036746
• Length: 889
• Species: Drosophila melanogaster
• Sequence 2: XP_005245003.1
• Gene: CRTC2 / 200186
• HGNCID: 27301
• Length: 698
• Species: Homo sapiens
• Alignment Length: 922
• Identity: 196/922 - (21%)
• Similarity: 275/922 - (29%)
• Gaps: 371/922 - (40%)

  Fly     2 ANPRKFSEKIALQKQKQAEGTAEFERIMKEVYATKRDEPPANQKILDGLVGGQEVSQSSPGAGNG 66
            :||||||||||||||:|||.||.||.:|.::.:|:...    ||:............|.|.. |.
Human    17 SNPRKFSEKIALQKQRQAEETAAFEEVMMDIGSTRLQA----QKLRLAYTRSSHYGGSLPNV-NQ 76

  Fly    67 TGGGGSGSGSGASGGGASPDGLGGGGGSPTAYRESRGRSVGVGPMRRPSERKQDRSPYGSSSTQQ 131
            .|.|.:...|.......|.......|......|:.|..   |.|:||.: |..|.|||
Human    77 IGSGLAEFQSPLHSPLDSSRSTRHHGLVERVQRDPRRM---VSPLRRYT-RHIDSSPY------- 130

  Fly   132 TLDNGQLNPHLLGPPTAESLWR-----------------------RSSSDSALHQSALVAGFNSD 173
                   :|..|.|| .||.||                       |:|||||||.|.:
Human   131 -------SPAYLSPP-PESSWRRTMAWGNFPAEKGQLFRLPSALNRTSSDSALHTSVM------- 180

  Fly   174 VNSMGANYQQQQHQQQQQPG-QPRSHSPHH--GI-NRTMSPQAQRRKSPLLQPHQLQLQQLQQQQ 234
                      ....|...|| .|.|..|..  || :..|.|:....:.|.::.:.|..:.|.:
Human   181 ----------NPSPQDTYPGPTPPSILPSRRGGILDGEMDPKVFLFQVPAIEENLLDDKHLLK-- 233

  Fly   235 QQMQHQHQLHQQLQMQQLQQHQQQHQQQQQQQNTPYNNAKFTNPVFRPLQDQVNFANT------- 292
                                              |::..|.::...||...:|...|.
Human   234 ----------------------------------PWDAKKLSSSSSRPRSCEVPGINIFPSPDQP 264

  Fly   293 -------------GSLPDLTALQNYGPQQQQQQSQQQPSQQQQQLQQTLSPVMSPHNHRRERDQS 344
                         |||||||.| ::.|          |.......::|..|.:|..|.......:
Human   265 ANVPVLPPAMNTGGSLPDLTNL-HFPP----------PLPTPLDPEETAYPSLSGGNSTSNLTHT 318

  Fly   345 PSPFSPAGGGGGAGPG-----------------------------SPYQQQQ--HSPTGNTQQQQ 378
            .:... ...|.|.|||                             ||..|.|  ||.........
Human   319 MTHLG-ISRGMGLGPGYDAPGLHSPLSHPSLQSSLSNPNLQASLSSPQPQLQGSHSHPSLPASSL 382

  Fly   379 QQHQQPSNS---PHLSFTNLATTQAAVTTFNPLPTLGPHNATDYRQPPNPPSPRSSPGLLSSVSA 440
            .:|..|:.|   |.||...|:::.::.:|.:|:  ||.           |..|.|:||      |
Human   383 ARHVLPTTSLGHPSLSAPALSSSSSSSSTSSPV--LGA-----------PSYPASTPG------A 428

  Fly   441 TDLHSSAPASPI----------RQQQQAHQQ----QQQQQQAQQQQQQFDNS------------Y 479
            :..|...|.||:          |.|||..:|    ......:..|....|.|            |
Human   429 SPHHRRVPLSPLSLLAGPADARRSQQQLPKQFSPTMSPTLSSITQGVPLDTSKLSTDQRLPPYPY 493

  Fly   480 NS----LNTSFHNQFEIFSLGDSNSSPEQQGFANNFVALDFDDLSGGGGGGPSGGGGSNGGGLTN 540
            :|    |.|..|          :..|.:|.|..:...::.      ..||.|.        |..:
Human   494 SSPSLVLPTQPH----------TPKSLQQPGLPSQSCSVQ------SSGGQPP--------GRQS 534

  Fly   541 GYNKPEMLDFSELSGSPEASGNNNHMRRGVSNLNNNGLSNGVVGSTHNGSTNLNGAGN----NNS 601
            .|            |:|...|.:.|.::                |.|...::.| .||    :..
Human   535 HY------------GTPYPPGPSGHGQQ----------------SYHRPMSDFN-LGNLEQFSME 570

  Fly   602 SSGGGTAQDPLGITTSP----VPSPLGCPSSPLPIPIPMSAQSSPQQQHHHHQQQQQQHHQQQHH 662
            |.......||.|.:..|    ...|:|.|..|
Human   571 SPSASLVLDPPGFSEGPGFLGGEGPMGGPQDP--------------------------------- 602

  Fly   663 QQQQLSLSLHHSPHHSPMHSPHHGNSPLSSSSPVSHNACSNSNVVMNHQQQQQQHHHQQHHHQGS 727
                     |...|.:..|...||:.|               |:::.....           .|.
Human   603 ---------HTFNHQNLTHCSRHGSGP---------------NIILTGDSS-----------PGF 632

  Fly   728 SQSHTPTTANIPSIIFSDYSSNADYTREIFDSLDLDLGQMD--------VAGLQMLSDQNP-IMI 783
            |:......|.:|....|            ...|:|.||..|        :.||.||||  | .::
Human   633 SKEIAAALAGVPGFEVS------------AAGLELGLGLEDELRMEPLGLEGLNMLSD--PCALL 683

  Fly   784 ADPNIEDSFRRD 795
            .||.:|:|||.|
Human   684 PDPAVEESFRSD 695

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Crtc	NP_001261997.1	TORC_N	3..61	CDD:289639	26/57 (46%)
		TORC_C	739..795	CDD:289641	20/64 (31%)
CRTC2	XP_005245003.1	TORC_N	18..72	CDD:289639	26/57 (46%)
		TORC_M	168..325	CDD:289640	42/221 (19%)
		TORC_C	620..697	CDD:289641	26/116 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159530
Domainoid	1	1.000	51	1.000	Domainoid score	I11587
eggNOG	1	0.900	-	-		E1_28MKB
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	77	1.000	Inparanoid score	I5257
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001294
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13589
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1320
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.980