Protein Alignment MYO18A and MYO1

DIOPT Version :9

• Sequence 1: NP_001333694.1
• Gene: MYO18A / 399687
• HGNCID: 31104
• Length: 2058
• Species: Homo sapiens
• Sequence 2: NP_011888.1
• Gene: MYO1 / 856418
• SGDID: S000001065
• Length: 1928
• Species: Saccharomyces cerevisiae
• Alignment Length: 2036
• Identity: 459/2036 - (22%)
• Similarity: 850/2036 - (41%)
• Gaps: 524/2036 - (25%)

Human   364 VWLVHRDGFSLASQLKSEELNLPEGKVRVKLDHDGAILDVDE-----------DDVEKANAPSCD 417
            ||:.......:..:|.|.::|  :.|...:.:..|.:..:|.           .||...|..:.|
Yeast    13 VWIPDEKEVFVKGELMSTDIN--KNKFTGQEEQIGIVHPLDSTEVSNLVQVRISDVFPVNPSTFD 75

Human   418 RLEDLASLVYLNESSVLHTLRQRYGASLLHTYAGPSLLVLGPRGAPAVYSEKVMHMFKGCR---- 478
            ::|:::.|.:|||.|||:.|.:||...|::||:|..|:.:.|.....:|||..::::....
Yeast    76 KVENMSELTHLNEPSVLYNLEKRYDCDLIYTYSGLFLVAINPYHNLNLYSEDHINLYHNKHNRLS 140

Human   479 --------REDMAPHIYAVAQTAYRAMLMSRQDQSIILLGSSGSGKTTSCQHLVQYLAT------ 529
                    .|.:.|||:|:|:.||..:|...:||||::.|.||:|||.:.:.::||||:
Yeast   141 KSRLDENSHEKLPPHIFAIAEEAYENLLSEGKDQSILVTGESGAGKTENTKKILQYLASITSGSP 205

Human   530 --IAGISGNKVFSVEKWQALYT--LLEAFGNSPTIINGNATRFSQILSLDFDQAGQVASASIQTM 590
              ||.:||:.:....:.:.|.:  :||:|||:.|:.|.|::||.:.:.::|::.|.:..|.|:..
Yeast   206 SNIAPVSGSSIVESFEMKILQSNPILESFGNAQTVRNNNSSRFGKFIKIEFNEHGMINGAHIEWY 270

Human   591 LLEKLRVARRPASEATFNVFYYLLACGDGTLRTELHLN-------HLAENNVFGIVPLAKPEEKQ 648
            ||||.|:..:.:.|..:::||.||:..|.:....|.|.       .:..|:...|:|.....|
Yeast   271 LLEKSRIVHQNSKERNYHIFYQLLSGLDDSELKNLRLKSRNVKDYKILSNSNQDIIPGINDVE-- 333

Human   649 KAAQQFSKLQAAMKVLGISPDEQKACWFILAAIYHLGAAGATKEAPEEQAEAAEAGRKQFARHEW 713
                .|.:|.:|:.::|.|.|:.:..:.::|.|..:|    ..|...::||.|.......|
Yeast   334 ----NFKELLSALNIIGFSKDQIRWIFQVVAIILLIG----NIEFVSDRAEQASFKNDVSA---- 386

Human   714 AQKAAYLLGCSLEELSSAIFKHQHKGGT--LQRSTSFRQGPEESGLGDGTGPKLSALECLEGMAA 776
               ....||...::..:||.:.:.|.|.  :.:|.:.:|                |...|..::.
Yeast   387 ---ICSNLGVDEKDFQTAILRPRSKAGKEWVSQSKNSQQ----------------AKFILNALSR 432

Human   777 GLYSELFTLLVSLVNRALKSSQHSLCSMMIVDTPGFQNPEQGGSARGASFEELCHNYTQDRLQRL 841
            .||..||..:|.::|:.|.....:|..:.::|..||:..|..      |||:||.|||.::||:.
Yeast   433 NLYERLFGYIVDMINKNLDHGSATLNYIGLLDIAGFEIFENN------SFEQLCINYTNEKLQQF 491

Human   842 FHERTFVQELERYKEENI-----------ELAFDDLE---PPTDDSVAAVDQASHQSLVRSLART 892
            |:...||.|...|.:|||           :|..|.:|   |||
Yeast   492 FNNHMFVLEQSEYLKENIQWDYIDYGKDLQLTIDLIESKGPPT---------------------- 534

Human   893 DEARGLLWLLEEEALVPGASEDTLLERLFSYYGPQEGDKKGQSPLLHSSKPHHFLLGHSHGTNWV 957
                |:|.||:|||::|.:::::...:|.|.: .|...|..:|.|.:.     |:|.|..|.  |
Yeast   535 ----GVLPLLDEEAVLPKSTDESFYSKLISTW-DQNSSKFKRSRLKNG-----FILKHYAGD--V 587

Human   958 EYNVTGWLNYTKQNPATQNAPRLLQDSQKKIISNLFLGRAGSATVLSGSIAGLEGGSQLALRRAT 1022
            ||.|.|||:..| :|...|...||..||..|||.||......:     |.||:|........:.:
Yeast   588 EYTVEGWLSKNK-DPLNDNLLSLLSSSQNDIISKLFQPEGEKS-----SSAGVEANISNQEVKKS 646

Human  1023 SMRKTFTTGMAAVKKKSLCIQMKLQVDALIDTIKKSKLHFVHCFLPVAEGWAGEPRSASSRRVSS 1087
            :...||.|..:..:::.:         .|::.:..:..|||.|.:|           .:.::|.:
Yeast   647 ARTSTFKTTSSRHREQQI---------TLLNQLASTHPHFVRCIIP-----------NNVKKVKT 691

Human  1088 SSELDLPSGDHCEAGLLQLDVPLLRTQLRGSRLLDAMRMYRQGYPDHMVFSEFRRRFDVLAP-HL 1151
            .:.                  .|:..|||.:.:|:.:|:.|:|||:.:.|.||.:|:.:|.| :.
Yeast   692 FNR------------------RLILDQLRCNGVLEGIRLAREGYPNRIAFQEFFQRYRILYPENS 738

Human  1152 TKKHGRNYIVVDERRAVEELLECLDLEKSSCCMGLSRVFFRAGTLARLEEQRDEQTSRNLTLFQA 1216
            |.....:.:....::..|.||..|.|:.....:|.:::||:||.||.||:|:|.:.:..:....|
Yeast   739 TTTTFSSKLKASTKQNCEFLLTSLQLDTKVYKIGNTKLFFKAGVLADLEKQKDVKLNNIMIKLTA 803

Human  1217 ACRGYLAR-------QHFKKRKIQDLAIRCVQKNIKKNKGVKDWPWWKLFTTVRPLI-------E 1267
            ..|||..|       |..||.::.....|..      |:.||:.||:.||..::||:       .
Yeast   804 TIRGYTVRKEITYHLQKLKKTRVIGNTFRLY------NRLVKEDPWFNLFIRIKPLLTSSNDMTR 862

Human  1268 VQLSEEQIRNKDEEIQQLRSKL----EKAEKERNELRLNSDRL----------ESRISEL-TSEL 1317
            .:...|||.....::|::.||.    ||.:|..|||....|.|          ||.::.: ||..
Yeast   863 TKKFNEQINKLKNDLQEMESKKKFLEEKNQKTVNELENTQDLLNQEKENLRKNESLLNRVKTSSE 927

Human  1318 TDERNTGESASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVME--MEVMEAR---LIR-AAE 1376
            |.::...:..|: .|..:.|:|...:.::|...:...|::.:...|  :|.:.::   ||: .::
Yeast   928 TLQKQFDDLVSE-KDEISREKLEVAQNLEEAHQKIQGLQETIREREATLEKLHSKNNELIKQISD 991

Human  1377 INGEVDDDDAG----GEWRLKYE---RAVREVDFTKKRLQQEFEDKLEVEQQN------------ 1422
            :|.::..:.:.    .|.:||.|   :.:::|..:|:...:.|.|||...:::
Yeast   992 LNCDISKEQSSQSLIKESKLKLENEIKRLKDVINSKEEEIKSFNDKLSSSEEDLDIKLVTLEKNC 1056

Human  1423 ------KRQLERRLGDLQADSE--------------ESQRALQQLKKKCQ--------------- 1452
                  .:.|.....||::.:|              ..:..|.::|:|..
Yeast  1057 NIAMSRLQSLVTENSDLRSKNENFKKEKAALNNQLKNKESELLKMKEKIDNHKKELATFSKQRDD 1121

Human  1453 ------RLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQR---EKLQREKLQREKD 1508
                  ::||||::|::.|...:....:::::...|..|..:..::.:.   |.|...|: :|.:
Yeast  1122 AVSEHGKITAELKETRIQLTEYKSNYQKIKEEYSNFQRETKEQEQKKRNSLVESLNDSKI-KELE 1185

Human  1509 MLLAEAFSLKQQLEEK----------------------------------DMDIAGFTQKVVSLE 1539
            ..|::..||.|.|.::                                  |:.:| ||:...:||
Yeast  1186 ARLSQEISLNQYLNKRISGNSVETNISSTRRSTSYSDDPLDKEDIIKKYYDLQLA-FTEITRNLE 1249

Human  1540 AELQD-----------------ISSQESKDEASLAKVKKQLRDLEAKV-------------KDQE 1574
            .|:::                 .|.::.|.:|.:.|:||.::|::..:             .|:|
Yeast  1250 NEIEEKKNLISRLRFTETRLASSSFEDQKIKAQMKKLKKLIQDMDPSIPLDSILNEPLDNCPDKE 1314

Human  1575 EELDEQAGTIQMLEQAKLRLEMEME---------RMRQTHSK--------EMESRD------EEV 1616
            .::::     .|||...|:.::::|         .:...|||        .:.|.|      |..
Yeast  1315 SDINK-----LMLEVDYLKRQLDIETRAHYDAENAISALHSKFRKIQGESSLSSSDIYKLKFEAS 1374

Human  1617 EEARQSCQKKLKQMEVQLE---------------EEYEDK-----------QKVLREK------- 1648
            ||..:|.:.|||.|.::..               .:||::           |::|.|.
Yeast  1375 EERVKSLEDKLKTMPLRDRTNLPVGDIIKNRDSISKYEEEIRYYKLENYKLQEILNESNGKLSQL 1439

Human  1649 ----RELEGKLATLSDQVNR--RDFESEKRLRKDLKRT-KALLADAQLMLDHLKNSAPSKREIAQ 1706
                |:.:.|.|.||:|::|  :|.||.:|.::.|..| |......:..:|.|:.:....||...
Yeast  1440 TLDLRQSKSKEALLSEQLDRLQKDLESTERQKELLSSTIKQQKQQFENCMDDLQGNELRLREHIH 1504

Human  1707 LKNQLEESEFTCAAAVKARKAM-----------EVEIEDLHLQIDD-------IAKAKTALEEQL 1753
            ...|.||.....|:.::..|..           |:|..|..:|:.:       :...|..|.:.|
Yeast  1505 ALKQAEEDVKNMASIIEKLKTQNKQKEKLIWEREMERNDSDMQLQETLLELKRVQDVKKILSDDL 1569

Human  1754 SRLQREKNEIQNR------LEEDQEDMNELMK------------KHKAAVAQASRDLAQINDLQA 1800
            :.|:...:.:::|      :...:|::|..:|            |:|...:....: |:|:||..
Yeast  1570 AHLKERLSAVEDRSQYTDEINRLKEELNCSLKAETNLKKEFATLKYKLETSTNDSE-AKISDLLK 1633

Human  1801 QL-------EEANKEK-------QELQEKLQALQSQVEFLEQSMVDKSLVSRQ------------ 1839
            ||       |..|.||       :||.:|.:||.::.|.|:..:|..:.:.::
Yeast  1634 QLDHYTKVVEMLNNEKDAISLAEKELYQKYEALNTECESLKGKIVSLTKIKQELESDLNQKTDAL 1698

Human  1840 -----------------EAKIRELETRLEFERTQVKRLESLASRLKEN----MEKLTEERDQRI- 1882
                             ..||:.||..|:.:..|..|...|...|:.:    .:|..:|:.:.|
Yeast  1699 QISNAALSSSTQKNKEITEKIKYLEETLQLQMEQNSRNGELVKTLQASCNGYKDKFDDEKQKNID 1763

Human  1883 -AAENREKEQ-NKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQADLKL-A 1944
             ..||:..:: |..||.||::..|.:.:...|.|..| |.||||..:        ||:.|||. .
Yeast  1764 LYEENQTLQKLNTDLQLQLKNLHERLSDTTEKNAWLS-KIHELENMV--------SLETDLKYEE 1819

Human  1945 FKRIGDLQAAIED-EMESDENEDLI-----NSEGDSDVDSELEDRVDGVKSWLSKNKGPSKAASD 2003
            .|:...|:.|:|: :.::.:..|:|     |.....:...:.|.::..::.::|:.:...|.:..
Yeast  1820 MKKNKSLERAVEELQTKNSQQTDVIELANKNRSEFEEATLKYEAQISDLEKYISQQELEMKKSIR 1884

Human  2004 DGS------LKSSSPTSYWKS 2018
            |.|      .:.:....:|||
Yeast  1885 DNSSYRDKVQEMAQEIEFWKS 1905

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYO18A	NP_001333694.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..34
		Interaction with actin	114..118
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	140..167
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1469..1499		3/32 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1871..1920		14/51 (27%)
MYO1	NP_011888.1	COG5022	2..1691	CDD:227355	411/1811 (23%)
		Smc	1534..>1890	CDD:224117	77/365 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45615
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910