Protein Alignment MYO18A and zip

DIOPT Version :10

• Sequence 1: NP_001333694.1
• Gene: MYO18A / 399687
• HGNCID: 31104
• Length: 2058
• Species: Homo sapiens
• Sequence 2: NP_523860.2
• Gene: zip / 38001
• FlyBaseID: FBgn0287873
• Length: 2056
• Species: Drosophila melanogaster
• Alignment Length: 1899
• Identity: 501/1899 - (26%)
• Similarity: 896/1899 - (47%)
• Gaps: 376/1899 - (19%)

Human   316 LSRSWL----RSGEGPRRE--PSDLD-SEAASHAHSQ------AKTEEQI--------------- 352
            :..:||    :|...|:.|  .|::. .:||::..::      ||..|::
  Fly     1 MKSAWLALKSKSALHPKSEYPVSNIHYPKAANYRQTRNYLEIAAKMSEEVDRNDPELKYLSVERN 65

Human   353 -----AAEEAWNETEKVWLVHRDGFSLASQLKSEELNLPEGKVRVKLDHDGAILDVDEDDVEKAN 412
                 |.:..|.:...||:.|.:...:|:.:|.|.    ..:|.|:|...|..:.:..||::|.|
  Fly    66 QFNDPATQAEWTQKRLVWVPHENQGFVAASIKREH----GDEVEVELAETGKRVMILRDDIQKMN 126

Human   413 APSCDRLEDLASLVYLNESSVLHTLRQRYGASLLHTYAGPSLLVLGPRGAPAVYSEKVMHMFKGC 477
            .|..|::||:|.|..|||:||||.::.||.:.|::||:|...:|:.|.....:|:||:|..:||.
  Fly   127 PPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGI 191

Human   478 RREDMAPHIYAVAQTAYRAMLMSRQDQSIILLGSSGSGKTTSCQHLVQYLATIA----------- 531
            :|.::.||::|:..:|||.||..|:||||:..|.||:|||.:.:.::|:||.:|
  Fly   192 KRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVP 256

Human   532 --------GISGNKVFSVE------------------------------KWQALYT--LLEAFGN 556
                    .::.||...|:                              :.|.|..  :||||||
  Fly   257 HPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGN 321

Human   557 SPTIINGNATRFSQILSLDFDQAGQVASASIQTMLLEKLRVARRPASEATFNVFYYLLACGDGTL 621
            :.|:.|.|::||.:.:.::||.:|.::.|:|:|.||||.|..|:...|.||::||.|||......
  Fly   322 AKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQ 386

Human   622 RTELHLNHLAENNVF---GIVPLAKPEEKQKAAQQFSKLQA---AMKVLGISPDEQKACWFILAA 680
            |.:..|:.: ::..|   |.:|:       .....:::.||   :|.::|::.::..:.:.|::|
  Fly   387 REKFILDDV-KSYAFLSNGSLPV-------PGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSA 443

Human   681 IYHLGAAGATKEAPEEQAEAAEAGRKQFARHEWAQKAAYLLGCSLEELSSAIFKHQHKGGTLQRS 745
            :...|:....:|...:||...:        :..|||.|:|||.|:.:::.|....:.|.|  :..
  Fly   444 VLLFGSMKFRQERNNDQATLPD--------NTVAQKIAHLLGLSVTDMTRAFLTPRIKVG--RDF 498

Human   746 TSFRQGPEESGLGDGTGPKLSALECLEGMAAGLYSELFTLLVSLVNRALKSSQHSLCSMM-IVDT 809
            .:..|..|:...            .:|.:|...|..:|..||:.:||:|..::....|.: |:|.
  Fly   499 VTKAQTKEQVEF------------AVEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDM 551

Human   810 PGFQNPEQGGSARGASFEELCHNYTQDRLQRLFHERTFVQELERYKEENIELAFD----DLEPPT 870
            .||:..|..      |||:||.|||.::||:||:...|:.|.|.|:.|.||..|.    ||:|..
  Fly   552 AGFEIFELN------SFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTI 610

Human   871 DDSVAAVDQASHQSLVRSLARTDEARGLLWLLEEEALVPGASEDTLLERLFSYYGPQEGDKKGQS 935
            |             |:      |:..|::.||:||...|.|::.|.:::|.|
  Fly   611 D-------------LI------DKPGGIMALLDEECWFPKATDKTFVDKLVS------------- 643

Human   936 PLLHSSKPH----------HFLLGHSHGTNWVEYNVTGWLNYTKQNPATQNAPRLLQDSQKKIIS 990
              .||..|.          .|.:.|..|.  |:|:...|| ....:|..:|...|||.||...:.
  Fly   644 --AHSMHPKFMKTDFRGVADFAIVHYAGR--VDYSAAKWL-MKNMDPLNENIVSLLQGSQDPFVV 703

Human   991 NLFLGRAGSATVLSGSIAGLEGGSQLALRRATSMRKTFTTGMAAVKK---KSLCIQMKLQVDALI 1052
            |::            ..|.:.|.:|.||        |.|...|..:|   :::....|.|:..|:
  Fly   704 NIW------------KDAEIVGMAQQAL--------TDTQFGARTRKGMFRTVSHLYKEQLAKLM 748

Human  1053 DTIKKSKLHFVHCFLPVAEGWAGEPRSASSRRVSSSSELDLPSGDHCEAGLLQLDVPLLRTQLRG 1117
            ||::.:..:||.|.:|..|..||                             ::|.||:..|||.
  Fly   749 DTLRNTNPNFVRCIIPNHEKRAG-----------------------------KIDAPLVLDQLRC 784

Human  1118 SRLLDAMRMYRQGYPDHMVFSEFRRRFDVLAPHLTKKHGRNYIVVDERRAVEELLECLDLEKSSC 1182
            :.:|:.:|:.|||:|:.:.|.|||:|:::|.|::..|.     .:|.::|.|::::.|:|:.:..
  Fly   785 NGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKG-----FMDGKKACEKMIQALELDSNLY 844

Human  1183 CMGLSRVFFRAGTLARLEEQRDEQTSRNLTLFQAACRGYLARQHFKKRKIQDLAIRCVQKNIKKN 1247
            .:|.|::|||||.||.|||:||.:.|..:..|||.|||:|||::::||..|..|||.:|:|....
  Fly   845 RVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNYQKRLQQLNAIRIIQRNCAAY 909

Human  1248 KGVKDWPWWKLFTTVRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISE 1312
            ..:::|.||:|:|.|:||:||...||::..|::|::|:|.||:...|       |:...|.:..:
  Fly   910 LKLRNWQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQVREKLDTLAK-------NTQEYERKYQQ 967

Human  1313 LTSELTDERNTGESASQLLDAETAERLRAEKEM----KELQTQYDALKKQMEVMEMEVMEARLIR 1373
            ...|.|               ..||:|:||.|:    :|.:::..|.|:::|.| |:.:|.|:
  Fly   968 ALVEKT---------------TLAEQLQAEIELCAEAEESRSRLMARKQELEDM-MQELETRI-- 1014

Human  1374 AAEINGEVDDDDA---GGEWRLKYERAVREVDFTKKRLQ---QEFEDKLEVEQ--QNKRQLERRL 1430
                  |.:::..   |||               ||:|:   |:.|::||.|:  :.|.|||:..
  Fly  1015 ------EEEEERVLALGGE---------------KKKLELNIQDLEEQLEEEEAARQKLQLEKVQ 1058

Human  1431 GDLQADSEESQRAL-----QQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAH 1490
            .|.:....|...||     |:|.|:.:.|.....|....|..::.:...|.|.:.:.::.:|:..
  Fly  1059 LDAKIKKYEEDLALTDDQNQKLLKEKKLLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISELE 1123

Human  1491 EEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEAS 1555
            |...:::.||::..|.|..:..|...||:||.|:.:.:.....::...|.||.....:..::.|:
  Fly  1124 ERLHKDQQQRQESDRSKRKIETEVADLKEQLNERRVQVDEMQAQLAKREEELTQTLLRIDEESAT 1188

Human  1556 LAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEV--EE 1618
            .|..:|..|:||:::.:.:|:|:.:.......|:.:..|..|:|.::   ::.::|.|...  :|
  Fly  1189 KATAQKAQRELESQLAEIQEDLEAEKAARAKAEKVRRDLSEELEALK---NELLDSLDTTAAQQE 1250

Human  1619 ARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEG-KLATLSDQVNRRDFESEKRLRKDLKRTKA 1682
            .|...:::|..::..||||..:.:.||.:.|.... :|.:::||:            ::|::.|.
  Fly  1251 LRSKREQELATLKKSLEEETVNHEGVLADMRHKHSQELNSINDQL------------ENLRKAKT 1303

Human  1683 LLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKT 1747
            :|..|:..|:  ..:|....|:..:.:..:|::       :.||..|.:|.:|.:::.:|.:|::
  Fly  1304 VLEKAKGTLE--AENADLATELRSVNSSRQEND-------RRRKQAESQIAELQVKLAEIERARS 1359

Human  1748 ALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQEL 1812
            .|:|:.::||:|...|.|:|||.:       .|..|||..||...:|:.:.|..|||..::|..|
  Fly  1360 ELQEKCTKLQQEAENITNQLEEAE-------LKASAAVKSASNMESQLTEAQQLLEEETRQKLGL 1417

Human  1813 QEKLQALQSQVEFLEQSMVDKSLVSRQ-EAKIRELETRL-------EFERTQVKRLESLASRLKE 1869
            ..||:.::|:.|.|::.:.:.....|. |.|:.|:.|::       |.:....|.||....||.:
  Fly  1418 SSKLRQIESEKEALQEQLEEDDEAKRNYERKLAEVTTQMQEIKKKAEEDADLAKELEEGKKRLNK 1482

Human  1870 NMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHEL----------- 1923
            ::|.|..:..:.||..:|..:..|::|.:|.|...|:.....|..|..:|:...
  Fly  1483 DIEALERQVKELIAQNDRLDKSKKKIQSELEDATIELEAQRTKVLELEKKQKNFDKILAEEKAIS 1547

Human  1924 -----EMDLESLEAANQ-----SLQADLKLAFKRIGDLQAAIEDEMESDENE--DLINSEGDSDV 1976
                 |.|....||..:     |:..:|..||.:|.||    |::.::.:||  ||.|::|.:|.
  Fly  1548 EQIAQERDTAEREAREKETKVLSVSRELDEAFDKIEDL----ENKRKTLQNELDDLANTQGTADK 1608

Human  1977 D-SELEDRVDGVKSWLSKNKGPSKAASDDGSLKSSSPTSYWKSLAPDRSDDEHDPLDN----TSR 2036
            : .|||.....::|.|::.|..::...||..|...:......::...||..|.|.|..    ..:
  Fly  1609 NVHELEKAKRALESQLAELKAQNEELEDDLQLTEDAKLRLEVNMQALRSQFERDLLAKEEGAEEK 1673

Human  2037 PRYSHSYLSDSDTE 2050
            .|.....|.|.:||
  Fly  1674 RRGLVKQLRDLETE 1687

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYO18A	NP_001333694.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..34
		Interaction with actin	114..118
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	140..167
		PDZ_MYO18-like	220..308	CDD:467229
		COG5022	393..1924	CDD:227355	442/1649 (27%)
		MYSc_Myo18	431..1192	CDD:276837	224/835 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1469..1499		4/29 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1871..1920		12/48 (25%)
zip	NP_523860.2	Myosin_N	79..122	CDD:460670	11/46 (24%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	224/835 (27%)
		Myosin_tail_1	931..2011	CDD:460256	202/838 (24%)