Protein Alignment MYO18A and Mhc

DIOPT Version :9

• Sequence 1: NP_001333694.1
• Gene: MYO18A / 399687
• HGNCID: 31104
• Length: 2058
• Species: Homo sapiens
• Sequence 2: NP_001162991.1
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Alignment Length: 1930
• Identity: 489/1930 - (25%)
• Similarity: 872/1930 - (45%)
• Gaps: 418/1930 - (21%)

Human   349 EEQIAAEEAWNETEKVWLV-HRDGFSLASQLKSEELNLPEGKVRVKLDHDGAILDVDEDDVEKAN 412
            :.:|...:.::..:..|:. .::|: |..::|:.:.::    |.|.| ..|.:.|:..:.|||.|
  Fly    23 QRRIDQSKPYDSKKSCWIPDEKEGY-LLGEIKATKGDI----VSVGL-QGGEVRDIKSEKVEKVN 81

Human   413 APSCDRLEDLASLVYLNESSVLHTLRQRYGASLLHTYAGPSLLVLGPRGAPAVYSEKVMHMFKGC 477
            .|..:::||:|.:..||...|||.|||||.|.|::||:|...:.:.|.....||:.:...|::|.
  Fly    82 PPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGK 146

Human   478 RREDMAPHIYAVAQTAYRAMLMSRQDQSIILLGSSGSGKTTSCQHLVQYLATIAGISGNKVFSVE 542
            ||.::.|||:|::..||..||.:..:||:::.|.||:|||.:.:.::.|.||:.........:..
  Fly   147 RRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKS 211

Human   543 KW----QALYT--LLEAFGNSPTIINGNATRFSQILSLDFDQAGQVASASIQTMLLEKLRVARRP 601
            |.    |.:.|  :||||||:.|:.|.|::||.:.:.:.|...|::|.|.|:|.||||.||..:.
  Fly   212 KGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQ 276

Human   602 ASEATFNVFYYLLA---------CGDGTLRTELHLNHLAENNVFGIVPLAKPEEKQKAAQQFSKL 657
            :.|.::::||.:::         |   .|...::..|:...   |.|.:|..::    |::||..
  Fly   277 SLERSYHIFYQIMSGSVPGVKDIC---LLTDNIYDYHIVSQ---GKVTVASIDD----AEEFSLT 331

Human   658 QAAMKVLGISPDEQKACWFILAAIYHLGAAGATKEAPEEQAEAAEAGRKQFARHEWAQKAAYLLG 722
            ..|..:||.:..|::..:.|.||:.|:|.....:...|||||  :.|.::..|      .:.|.|
  Fly   332 DQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAE--QDGEEEGGR------VSKLFG 388

Human   723 CSLEELSSAIFKHQHKGGTLQRSTSFRQGPEESGLGDGTGPKLSALECLEGMAAGLYSELFTLLV 787
            |...||...:.|.:.|.|    :....||.....:.:..|          .:..|::..||..||
  Fly   389 CDTAELYKNLLKPRIKVG----NEFVTQGRNVQQVTNSIG----------ALCKGVFDRLFKWLV 439

Human   788 SLVNRALKSSQHSLCSMMIVDTPGFQNPEQGGSARGASFEELCHNYTQDRLQRLFHERTFVQELE 852
            ...|..|.:.|.....:.::|..||:..|..|      ||:||.|:|.::||:.|:...||.|.|
  Fly   440 KKCNETLDTQQKRQHFIGVLDIAGFEIFEYNG------FEQLCINFTNEKLQQFFNHHMFVLEQE 498

Human   853 RYKEENIELAFDDLEPPTDDSVAAVDQASHQSLVRSLARTDEARGLLWLLEEEALVPGASEDTLL 917
            .||.|.|:.||.|...   |.:|.:|      |:      ::..|:|.:||||::.|.|::.|..
  Fly   499 EYKREGIDWAFIDFGM---DLLACID------LI------EKPMGILSILEEESMFPKATDQTFS 548

Human   918 ERLFSYYGPQEGDKKGQSPLLHSSKP-------HHFLLGHSHGTNWVEYNVTGWLNYTKQNPATQ 975
            |:|.:.:       .|:|......||       .||.:.|..|.  |.||:||||...| :|...
  Fly   549 EKLTNTH-------LGKSAPFQKPKPPKPGQQAAHFAIAHYAGC--VSYNITGWLEKNK-DPLND 603

Human   976 NAPRLLQDSQKKIISNLFLGRAGSATVLSGSIAGLEGGSQLALRRATSMRKTFTTGMAAVKKKSL 1040
            ......:.||.|::..:|...||.:           ||.:.|..........|.|..:|.|:
  Fly   604 TVVDQFKKSQNKLLIEIFADHAGQS-----------GGGEQAKGGRGKKGGGFATVSSAYKE--- 654

Human  1041 CIQMKLQVDALIDTIKKSKLHFVHCFLPVAEGWAGEPRSASSRRVSSSSELDLPSGDHCEAGLLQ 1105
                  |:::|:.|::.::.|||.|.:|                    :|:..|.         .
  Fly   655 ------QLNSLMTTLRSTQPHFVRCIIP--------------------NEMKQPG---------V 684

Human  1106 LDVPLLRTQLRGSRLLDAMRMYRQGYPDHMVFSEFRRRFDVLAPHLTKKHGRNYIVVDERRAVEE 1170
            :|..|:..||..:.:|:.:|:.|:|:|:.|::.:|:.|:.::.|.|.:.      |..:::|.|.
  Fly   685 VDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLLQG------VEKDKKATEI 743

Human  1171 LLECLDLEKSSCCMGLSRVFFRAGTLARLEEQRDEQTSRNLTLFQAACRGYLARQHFKKRKIQDL 1235
            :::.:||.:....:|.::||||||.|.::||.|||:..:.::..||..||||:|:.|||.:.|.:
  Fly   744 IIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQRV 808

Human  1236 AIRCVQKNIKKNKGVKDWPWWKLFTTVRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAE------- 1293
            |::.||:|::|...::.|||:||:..|:||:.|...|       :||.:|..|.:|||
  Fly   809 ALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIE-------DEIARLEEKAKKAEELHAAEV 866

Human  1294 KERNELR-LNSDRLESRIS----------------ELTSELTDERNTGESASQLLDAETAERLRA 1341
            |.|.||. ||:..|..:.:                |..::||.::|..|  :||.|.:  |||..
  Fly   867 KVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLE--NQLRDIQ--ERLTQ 927

Human  1342 E--------KEMKELQTQYDALKKQMEVMEMEVMEARLIRAAE------INGEVDDDD------- 1385
            |        ::.|:...:...|||.:|.:|:.|.:|...:|.:      :|.|:...|
  Fly   928 EEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQDELINKLN 992

Human  1386 -----------AGGEWRLKYERAVREVDFTKKRLQQ---EFEDKLEVE-------QQNKRQLE-- 1427
                       ..||.....|..:..::..|.:|:|   |.||.||.|       :::||::|
  Fly   993 KEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVEKSKRKVEGD 1057

Human  1428 -----RRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELS 1487
                 ..:.||:.:.:|.::.:|:..|:...:||:|:|     |...|..|:.:.|:  ..:.:.
  Fly  1058 LKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLED-----EQVVVLKHQRQIKE--LQARIE 1115

Human  1488 QAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSL----EAEL----QD 1544
            :..||.:.|:..|.|.::::..|..|...|.::|||    ..|.|...:.|    ||||    :|
  Fly  1116 ELEEEVEAERQARAKAEKQRADLARELEELGERLEE----AGGATSAQIELNKKREAELSKLRRD 1176

Human  1545 ISSQESKDEASLAKVKK--------------QLRDLEAKVKDQEEE------------------- 1576
            :.....:.|::||.::|              ||..|:||.:.::.|
  Fly  1177 LEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEK 1241

Human  1577 --------------------LDEQAGTIQMLEQAKLRLEME-MERMRQTHSKEMESRDEEVEEAR 1620
                                |||...|:...:.:|.:|.:| .:.:||.  :|.||:..::.:.:
  Fly  1242 AAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQL--EEAESQVSQLSKIK 1304

Human  1621 QSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVN---------------------- 1663
            .|...:|:..:...:||..::..:|.:.|.||..|..|.:||.
  Fly  1305 ISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQV 1369

Human  1664 -RRDFESE-----KRLRKDLKRTKALLADAQLMLDHL--------KNSAPSKREIAQLKNQLEES 1714
             |..:||:     :.|.:..::.:|.||:|:..::.|        |.......|:..|:.:::.:
  Fly  1370 WRSKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRA 1434

Human  1715 EFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMK 1779
            .....||.|.:||.:..|.:..|::||:|....|.:::......|...::...||.||.:.
  Fly  1435 NAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLE---- 1495

Human  1780 KHKAAVAQASRDLA-QINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKI 1843
                ||.:.:::|| ::.||..|:.|..:...|:::..:.|:::.:.|             :|.:
  Fly  1496 ----AVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDEL-------------QAAL 1543

Human  1844 RELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGE 1908
            .|.|..||.|..:|.|.:...|::::.:::..:|:::..  ||..|..    ||.|...:..:..
  Fly  1544 EEAEAALEQEENKVLRAQLELSQVRQEIDRRIQEKEEEF--ENTRKNH----QRALDSMQASLEA 1602

Human  1909 LARKEAEASRKKHELEMDLESLE-------AANQSLQADLKLAFKRIGDLQAAIEDEMES--DEN 1964
            .|:.:|||.|.|.:||.|:..||       .||...|.::|...:::.|:|.|:|:|..:  |..
  Fly  1603 EAKGKAEALRMKKKLEADINELEIALDHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAR 1667

Human  1965 EDL-INSEGDSDVDSELEDRVDGVKSWLSKNKGPSKAASDDGSLKSSSPTSYWKSLAPDRSDDEH 2028
            |.| |:....:.:.:|||:.    ::.|.:        :|.|..::.      :.||     |.|
  Fly  1668 EQLGISERRANALQNELEES----RTLLEQ--------ADRGRRQAE------QELA-----DAH 1709

Human  2029 DPLDNTSRPRYS---------------HSYLSDSDTEAKLTETNA 2058
            :.|:..|....|               ||.|.:...|||.:|..|
  Fly  1710 EQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKA 1754

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYO18A	NP_001333694.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..34
		Interaction with actin	114..118
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	140..167
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1469..1499		6/29 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1871..1920		12/48 (25%)
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	9/42 (21%)
		MYSc	81..777	CDD:214580	228/813 (28%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	214/782 (27%)
		Myosin_tail_1	842..1897	CDD:279860	220/987 (22%)
		V_Alix_like	1557..1877	CDD:187408	55/227 (24%)
		ATP-synt_B	<1671..1771	CDD:304375	22/107 (21%)
		TMPIT	1739..>1825	CDD:285135	6/16 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810