DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MYO18A and nmy-3

DIOPT Version :9

Sequence 1:	NP_001333694.1	Gene:	MYO18A / 399687	HGNCID:	31104	Length:	2058	Species:	Homo sapiens
Sequence 2:	NP_501620.2	Gene:	nmy-3 / 177750	WormBaseID:	WBGene00012437	Length:	1464	Species:	Caenorhabditis elegans

Alignment Length:	1735	Identity:	410/1735 - (23%)
Similarity:	734/1735 - (42%)	Gaps:	385/1735 - (22%)

- Green bases have known domain annotations that are detailed below.

Human   333 DLDSEAASHAHSQAKTEEQIAAEEAWNETEKVWLVHRD--GFSLASQLKSEELNLPEGKVRVKLD 395
            ||:.....|..:: |.||:|  |:..|:   :| :..|  |:.:.:.: .|.|:    .:.|...
Worm     8 DLEPNILRHLQTK-KVEERI--EDLNNQ---IW-IEDDLYGYRMVTVI-DEGLS----DLLVGFR 60

Human   396 HDGAILDVDEDDVEKANAPSCDRL-EDLASLVYLNESSVLHTLRQRYGASLLHTYAGPSLLVLGP 459
            .:....:....:..|...||.:.. |||.:|...|.::||:.|:.||.::::||:.|...:|:.|
Worm    61 DEQGFFEKKRIEKTKCEVPSLNNYSEDLCTLTQPNAATVLNALKIRYTSNVIHTFCGLFCVVINP 125

Human   460 -RGAPAVYSEKVMHMFKGCRREDMAPHIYAVAQTAYRAMLMSRQDQSIILLGSSGSGKTTSCQHL 523
             |..| :||::|..:::  .:.|:.||:|:|||.|:..:|...::|||::.|.||:|||.:.:.:
Worm   126 WRNIP-IYSDEVKQLYQ--LQNDLPPHVYSVAQNAFHGILKGGRNQSILITGESGAGKTENTKKI 187

Human   524 VQYLATIAGISGNKVFSVEKWQALYTLLEAFGNSPTIINGNATRFSQILSLDFDQAGQVASASIQ 588
            :.::.: :.:|.|.:........:  ||||.||:.|..|.|::||.:.:.::||:..::..|.|:
Worm   188 IDFILS-SSVSNNTIGDCVVTSGV--LLEAMGNARTTHNSNSSRFGKFIRIEFDENSKLIGAKIE 249

Human   589 TMLLEKLRVARRPASEATFNVFYYLLACGDGTLRTELHLNHLAENNVFGIVPLAKPEEKQK---- 649
            ..||||.||..:...:..|::||.:|:            |:. :|.....:.|:|...:.|
Worm   250 CYLLEKSRVVFQSDGDRNFHIFYQMLS------------NYF-DNPHKSFLKLSKKVNEYKYLRN 301

Human   650 ------AAQQFSKLQAAMKVLGISPDEQKACWFILAAIYHLG------AAGATKEAPEEQAEAAE 702
                  .|:.......|...:|:|.:|:...:.||:|:..:|      .:|......|...|
Worm   302 DDSMIDDAETAKMTDEAFTRIGLSEEEKIWIFQILSAVLWIGDIKFGERSGLDVSFVESMQE--- 363

Human   703 AGRKQFARHEWAQKAAYLLGCSLEELSSA------------IFKHQHKGGTLQRSTSFRQGPEES 755
                       ....|.||.....:|..|            |.|:|:...||..:::
Worm   364 -----------VDNIAELLEMKSSKLVDALTQPTIKVHDKLIRKNQNLAKTLSSASA-------- 409

Human   756 GLGDGTGPKLSALECLEGMAAGLYSELFTLLVSLVNRALK-SSQHSLCSM----MIVDTPGFQNP 815
                              ||..||..||..:|...|.|.. ....|.|.:    .::|..||:..
Worm   410 ------------------MAKILYERLFGWIVKRCNDAFSVDDTESTCRLSRFIAVLDIAGFEII 456

Human   816 EQGGSARGASFEELCHNYTQDRLQRLFHERTFVQELERYKEENI---ELAFDDLEPPTDDSVAAV 877
            |:.      |||:.|.|||.::||:.|:...|.:|...|.||.|   ::.|.:...||.|.:
Worm   457 EKN------SFEQFCINYTNEKLQQFFNHFMFAKEQSDYLEEGIKWTQVNFANHLQPTIDLI--- 512

Human   878 DQASHQSLVRSLARTDEARGLLWLLEEEALVPGASEDTLLERLFSYYGPQEGDKKGQSPLLHSSK 942
                           ::..|:|..||||.:||..||.:|||:|.|........||.:. ....|.
Worm   513 ---------------EKPMGILSFLEEECVVPNGSEKSLLEKLCSNLSNDSSFKKSKQ-TQKCST 561

Human   943 PHHFLLGHSHGTNWVEYNVTGWLNYTKQNPATQNAPRLLQDSQKKIISNLFLGRAGSATVLSGSI 1007
            ..||.:.|..|.  |.||:.|||:..:.|..| :...:|..|...::..||
Worm   562 IRHFYVQHYAGE--VHYNIDGWLDKNRDNVET-SVLDILSQSTHPLLKLLF-------------- 609

Human  1008 AGLEGGSQLALRRATSMRKTFTTGMAAVKKKSLCIQMKLQVDALIDTIKKSKLHFVHCFLPVAEG 1072
                  ..:.:....:.|.|.|....:...|:       |:..|:||:..|..||:.|
Worm   610 ------PPVPVNNLKTRRGTITNSTVSFLYKN-------QLQCLLDTLNSSSAHFIRC------- 654

Human  1073 WAGEPRSASSRRVSSSSELDLPSGDHCEAGLLQLDVPLLRTQLRGSRLLDAMRMYRQGYPDHMVF 1137
                        |.|:.| .||.         ::|.||:..||:.:.:|:.:|:.|:|||..:..
Worm   655 ------------VVSNYE-KLPG---------KIDAPLVLAQLKCNGVLEGIRICREGYPSRLSH 697

Human  1138 SEFRRRFDVLAPHLTKKHGRNYIVVDERRAVEELLECLDLEKSSCCMGLSRVFFRAGTLARLEEQ 1202
            |||..|:.:|..:..:..|     ..|:.....:.:...:.|....:|.:::|.:.|.::.||.:
Worm   698 SEFIERYSLLMKNKEQSKG-----ASEKEKCTLICQDAQVRKERYAVGKTKLFCKVGVISELETK 757

Human  1203 RDEQTSRNLTLFQAACRGYLARQH---FKKRKIQDLAIRCVQKNIKKNKGVKDWPWWKLFTTVRP 1264
            |:...|..:.|.||..| ||..|.   .:::|::  |:..:|.|:::...:..|||::::...|.
Worm   758 RNNYISSFIILIQANIR-YLNIQKDLIERRKKLE--AVVTIQDNVRQFAELSQWPWYRIYHLTRG 819

Human  1265 LIEVQLSEEQIRNKDEE-IQQLRSKLEKAEKERNELRL-NSDRLESRISELTSELTDERNTGESA 1327
            ||.        ||:|:| |::|.::..|.|:|..|:.: |.:.|:..:               ..
Worm   820 LIP--------RNRDKERIEELENEKLKLEEEIQEMEIKNEEALKENL---------------KL 861

Human  1328 SQLLDAETAERLRAEKEMKELQTQ--------YDALKKQMEVME-----MEVMEARL----IRAA 1375
            |.|||.|.:|:::.:||::|::.|        ....:|.||.||     ..|:|.:.    .:..
Worm   862 SMLLDREKSEKVKVQKELEEVEKQGREKLLEKEREFRKTMEEMEQNEEIFNVLERKYNEQHKKVM 926

Human  1376 EINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKR-----QLERRLGDLQA 1435
            ::|..:.:          |||.:.:::..|..|:.| ..||. |.||::     .||:.:.:..:
Worm   927 KMNDVLRE----------YERKIEQLNMEKTDLENE-NQKLR-ETQNRQDSHYSNLEKEVMEKSS 979

Human  1436 DSEESQRALQQL--KKKCQRLT-----AELQDTKLHLEGQ-------QVRNHELEKKQRRFDSEL 1486
            ..:|.|..:|:|  :...||||     ..|:|.|.....|       |....||.:|..|||:
Worm   980 LIDELQNQIQKLSDENNEQRLTIAKLETALEDEKARFARQNNTIGDMQKLISELNEKIARFDN-- 1042

Human  1487 SQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESK 1551
                 .|..|:....|::|||:.|..|..:.|:.::::       .:|:..|:.|     .::.|
Worm  1043 -----IALNERNSTRKIEREKEKLNEELTTAKEIIQKQ-------AKKIDELKEE-----CRKRK 1090

Human  1552 DEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEV 1616
            :|||  :::::|.|.||.:.|..:||.:.                ..||:     ||||.:.|:|
Worm  1091 NEAS--RLERKLEDKEAMMADCVKELKDS----------------HKERL-----KEMEQKVEDV 1132

Human  1617 ---------EEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKR 1672
                     |.:.|..|.:..|.|..::.:|         .|...|:|:||..|.:.....|...
Worm  1133 KRKNSKLENENSTQKSQIETFQRESSVDSDY---------GRSSSGRLSTLGRQYSLTSIGSFSS 1188

Human  1673 LRK-DLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLH 1736
            :|. .|...|..::|....:..|:. ..|..::......|:.|..|.....|.|:.:|:|.|...
Worm  1189 IRTVGLGSRKDSISDMTSSMYSLRR-RDSTYDMTSSTIGLQRSPSTSQVMEKERRILELEKEKAA 1252

Human  1737 LQID--------DIAKAK-TALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDL 1792
            :..|        |:.|:: :|:|.:...||....:..|:|:|....:|...|.......:..:.|
Worm  1253 INTDLQLVKRELDVYKSQLSAVESEKESLQTANRKQSNQLQETTRQLNSAQKNADNLALRLKKAL 1317

Human  1793 AQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQV 1857
            |..::.:.:.||:            .::|:.|.|   |..|..:.|.||    .|...|.:::::
Worm  1318 ADCDEWKKKHEES------------IVESKTEIL---MERKRAMDRAEA----CEKETELKQSRM 1363

Human  1858 KRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHE 1922
            ..:||....|...:.:...|.|       |.::...:|:..|: ::|.:|.      ...|.:..
Worm  1364 ATIESARMELGGELARTQSELD-------RCRQIIIQLEENLK-SQESLGN------SFGRHQTN 1414

Human  1923 LEMDLESLEAANQSLQADLKLAFKRIGDL--QAAIEDEMESDENE 1965
            |..::|:|...|.:|:|.::..:|:|..|  |....||:...||:
Worm  1415 LNFEIENLRDENCALKAKIRRQYKQIELLTQQDETNDELNHFENK 1459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYO18A	NP_001333694.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34
		Interaction with actin	114..118
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	140..167
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1469..1499		9/29 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1871..1920		8/48 (17%)
nmy-3	NP_501620.2	MYSc_class_II	97..747	CDD:276951	194/797 (24%)
nmy-3	NP_501620.2	Smc	864..>1463	CDD:224117	158/693 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161449881
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740