DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7497 and PTGFR

DIOPT Version :9

Sequence 1:	NP_001287100.1	Gene:	CG7497 / 39966	FlyBaseID:	FBgn0036742	Length:	412	Species:	Drosophila melanogaster
Sequence 2:	NP_000950.1	Gene:	PTGFR / 5737	HGNCID:	9600	Length:	359	Species:	Homo sapiens

Alignment Length:	383	Identity:	90/383 - (23%)
Similarity:	151/383 - (39%)	Gaps:	106/383 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 MPHNSTTVAPPKALYAN-----RNRLII--GVIIMVLGVFGNSLALFIL--ARKKLNKNSKYTLM 67
            |.::...|:|..||.:|     .|||.:  .||.|.:|:..||||:.||  |.::..:.||.:.:
Human     3 MNNSKQLVSPAAALLSNTTCQTENRLSVFFSVIFMTVGILSNSLAIAILMKAYQRFRQKSKASFL 67

  Fly    68 LRCLATNNLVA-LLGMLTTTLLKMYL---SKEVL---QSFIRVDCVGLVVWRFFGLSSGCIAAVM 125
            |  ||:..::. ..|.|....:.:::   .||.:   ||.:.....|:.: .|.||....:.:||
Human    68 L--LASGLVITDFFGHLINGAIAVFVYASDKEWIRFDQSNVLCSIFGICM-VFSGLCPLLLGSVM 129

  Fly   126 AAERWMALARPFIYHKHITYELIRKSINSILMIAVVITFLPFVGFGAY-IDES------NPDQLK 183
            |.||.:.:.:|..:...||.:.::..::.:.:.||.|..||.:|...| |..|      |.:.:|
Human   130 AIERCIGVTKPIFHSTKITSKHVKMMLSGVCLFAVFIALLPILGHRDYKIQASRTWCFYNTEDIK 194

  Fly   184 CIRYRDAPGVW-NKTYAVLFMVFGTLLCIVIVACNLFVAHTLLCVIGRSRTAKRHMHYDLVSRDK 247
                     .| ::.|.:||...|.|...|.:.||.....|||.|..:|:..::
Human   195 ---------DWEDRFYLLLFSFLGLLALGVSLLCNAITGITLLRVKFKSQQHRQ----------- 239

  Fly   248 NSAISIDPESSSGTTLYQTQLSTGSGNSHRSVQPARQYRHSVSVTMAATDSSPVEIKFAKLMAFL 312
                                     |.||          |...|              .:|:|.:
Human   240 -------------------------GRSH----------HLEMV--------------IQLLAIM 255

  Fly   313 SISFVICWMPQMIAIPLAIAPNRVPASNKFFIIADVLTALHFTS-----DPYVYVLSR 365
            .:| .|||.|.::    .:|...:..::........|.||...:     ||:||:|.|
Human   256 CVS-CICWSPFLV----TMANIGINGNHSLETCETTLFALRMATWNQILDPWVYILLR 308

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7497	NP_001287100.1	7tm_4	36..>221	CDD:304433	54/201 (27%)
PTGFR	NP_000950.1	7tmA_FP	27..316	CDD:320273	83/359 (23%)
		TM helix 1	28..54	CDD:320273	11/25 (44%)
		TM helix 2	66..92	CDD:320273	5/27 (19%)
		TM helix 3	108..138	CDD:320273	9/30 (30%)
		TM helix 4	150..172	CDD:320273	5/21 (24%)
		TM helix 5	197..226	CDD:320273	8/28 (29%)
		TM helix 6	242..272	CDD:320273	12/58 (21%)
		TM helix 7	283..308	CDD:320273	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144962
Domainoid	1	1.000	52	1.000	Domainoid score	I11441
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D412827at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11866
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950