DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7497 and PTGER4

DIOPT Version :9

Sequence 1:	NP_001287100.1	Gene:	CG7497 / 39966	FlyBaseID:	FBgn0036742	Length:	412	Species:	Drosophila melanogaster
Sequence 2:	NP_000949.1	Gene:	PTGER4 / 5734	HGNCID:	9596	Length:	488	Species:	Homo sapiens

Alignment Length:	420	Identity:	94/420 - (22%)
Similarity:	165/420 - (39%)	Gaps:	103/420 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 NSTTVAPPKALYANRNRLIIGVIIMVLGVFGNSLALFIL--ARKKLNKNSKYTLMLRCLATNNLV 77
            ||:....|..|   .:.:.|..::.:.||.||.:|:.:|  :||:..:.:.|||:.....|:
Human     7 NSSASLSPDRL---NSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTD--- 65

  Fly    78 ALLGMLTTTLLKMYLSKEVLQSFIRVDCVG--------LVVWRFFGLSSGCIAAVMAAERWMALA 134
             |||    |||   :|...:.::::....|        ..:..||.||...|...|:.||::|:.
Human    66 -LLG----TLL---VSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAIN 122

  Fly   135 RPFIYHKHITYELIRKSINSILMIAVVITFLPFVGFGAYIDESNPDQLKCIRYRDAPGVW----- 194
            ..:.|..::...|...::.::....|:...||.:|.|:          ..::|   |..|
Human   123 HAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGS----------SRLQY---PDTWCFIDW 174

  Fly   195 ------NKTYAVLFMVFGTLLCIVIVACNLFVAHTLLCVIGRSRTAKRHMHYDLVSRDKNSAISI 253
                  :..|:.::..|.:.|.:..|.||:.|...||           .||...:.|
Human   175 TTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALL-----------RMHRQFMRR-------- 220

  Fly   254 DPESSSGTTLYQTQLSTG-SGNSHRSVQPA----RQYRHSVSVTMAATDSSPVEIKFAKLMAFLS 313
               :|.||..:....:.. :...|.:..||    ..:|...|....|    ..||:...|:...|
Human   221 ---TSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIA----GAEIQMVILLIATS 278

  Fly   314 ISFVICWMPQMIAIPLAIAPNRV--PASNKFFIIADVLTALHFTS-----DPYVYVLSR----SK 367
            :..:||.:|.::.:.:    |::  |:..:.......|.|:...|     ||::|:|.|    ||
Human   279 LVVLICSIPLVVRVFV----NQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSK 339

  Fly   368 SI-NWSLLGCIKRWRSGWRPGGLRRSQSDQ 396
            :| ....|.|        |.||.||.:|.|
Human   340 AIEKIKCLFC--------RIGGSRRERSGQ 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7497	NP_001287100.1	7tm_4	36..>221	CDD:304433	45/205 (22%)
PTGER4	NP_000949.1	7tmA_PGE2_EP4	18..341	CDD:320270	80/376 (21%)
		TM helix 1	19..45	CDD:320270	7/25 (28%)
		TM helix 2	54..80	CDD:320270	11/36 (31%)
		TM helix 3	92..122	CDD:320270	9/29 (31%)
		TM helix 4	134..156	CDD:320270	4/21 (19%)
		TM helix 5	180..209	CDD:320270	7/28 (25%)
		TM helix 6	265..295	CDD:320270	7/33 (21%)
		TM helix 7	308..333	CDD:320270	7/24 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	356..376		3/6 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	437..475
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144961
Domainoid	1	1.000	52	1.000	Domainoid score	I11441
eggNOG	1	0.900	-	-		E33208_3BHKU
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	71	1.000	Inparanoid score	I5311
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D412827at33208
OrthoFinder	1	1.000	-	-		FOG0000857
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_108572
Panther	1	1.100	-	-	O	PTHR11866
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.800