Protein Alignment CG7497 and PTGER1

DIOPT Version :10

• Sequence 1: NP_648999.2
• Gene: CG7497 / 39966
• FlyBaseID: FBgn0036742
• Length: 412
• Species: Drosophila melanogaster
• Sequence 2: NP_000946.2
• Gene: PTGER1 / 5731
• HGNCID: 9593
• Length: 402
• Species: Homo sapiens
• Alignment Length: 422
• Identity: 98/422 - (23%)
• Similarity: 168/422 - (39%)
• Gaps: 61/422 - (14%)

  Fly     8 LDLLMPHNSTTVAPP-----KALYANRNRLIIGVIIMVLGVFGNSLALFILAR-----KKLNKNS 62
            |:|.:...:||.|.|     .|:..:.....:.:..|.||...|.|||.:||:     ::....:
Human     7 LNLSLAGEATTCAAPWVPNTSAVPPSGASPALPIFSMTLGAVSNLLALALLAQAAGRLRRRRSAA 71

  Fly    63 KYTLMLRCLATNNLV--ALLGMLTTTLLKMYLSKEVLQSFIRVDCVGLVVWRFFGLSSGCIAAVM 125
            .:.|.:..|...:|.  .:.|.|   :|::|.:.............|.:|  ||||....:...|
Human    72 TFLLFVASLLATDLAGHVIPGAL---VLRLYTAGRAPAGGACHFLGGCMV--FFGLCPLLLGCGM 131

  Fly   126 AAERWMALARPFIYHKHITYELIRKSINSILMIAVVITFLPFVGFGAYIDESNPDQLKCIRYRDA 190
            |.||.:.:.||.::...::....|.::.::..:|:.:..||....|.|  |.......|......
Human   132 AVERCVGVTRPLLHAARVSVARARLALAAVAAVALAVALLPLARVGRY--ELQYPGTWCFIGLGP 194

  Fly   191 PGVWNKT-YAVLFMVFGTLLCIVIVACNLFVAHTLLCVIGRSRTAKRHMHYDLVSRDKNSAISID 254
            ||.|.:. .|.||...|.:..:..:.||......||    |:|..:|       ||....|...|
Human   195 PGGWRQALLAGLFASLGLVALLAALVCNTLSGLALL----RARWRRR-------SRRPPPASGPD 248

  Fly   255 ---------PESSSGTTLYQ-TQLSTGSGNSHRSVQPARQYRHSVSVTMAATDSSPVEIKFAKLM 309
                     |.|:|.::... ...||..|.|..|....|...|.|.:.             .:|:
Human   249 SRRRWGAHGPRSASASSASSIASASTFFGGSRSSGSARRARAHDVEMV-------------GQLV 300

  Fly   310 AFLSISFVICWMPQMIAIPLAIAPNRVPASNKFFIIADVLTALHFTSDPYVYVLSRSKSINWSLL 374
            ..:.:| .|||.|.::.:.||:......:..:...:|..|.:.:...||:||:|.| :::...||
Human   301 GIMVVS-CICWSPMLVLVALAVGGWSSTSLQRPLFLAVRLASWNQILDPWVYILLR-QAVLRQLL 363

  Fly   375 GCIKRWRSGWRPG----GLRRSQSDQSRMRTT 402
            ..:.. |:|.:.|    ||..|..:.|.:|::
Human   364 RLLPP-RAGAKGGPAGLGLTPSAWEASSLRSS 394

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7497	NP_648999.2	7tm_GPCRs	34..365	CDD:475119	80/348 (23%)
		TM helix 1	34..55	CDD:410628	8/20 (40%)
		TM helix 2	68..87	CDD:410628	4/20 (20%)
		TM helix 3	99..127	CDD:410628	7/27 (26%)
		TM helix 4	150..166	CDD:410628	1/15 (7%)
		TM helix 5	195..218	CDD:410628	5/23 (22%)
		TM helix 6	306..328	CDD:410628	6/21 (29%)
		TM helix 7	340..365	CDD:410628	7/24 (29%)
PTGER1	NP_000946.2	7tm_GPCRs	33..358	CDD:475119	81/357 (23%)
		TM helix 1	35..59	CDD:410628	8/23 (35%)
		TM helix 2	74..96	CDD:410628	5/24 (21%)
		TM helix 3	111..133	CDD:410628	7/23 (30%)
		TM helix 4	156..172	CDD:410628	1/15 (7%)
		TM helix 5	200..223	CDD:410628	5/22 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	238..266		7/27 (26%)
		TM helix 6	296..318	CDD:410628	6/35 (17%)
		TM helix 7	330..355	CDD:410628	7/24 (29%)