DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7497 and PTGDR

DIOPT Version :9

Sequence 1:	NP_001287100.1	Gene:	CG7497 / 39966	FlyBaseID:	FBgn0036742	Length:	412	Species:	Drosophila melanogaster
Sequence 2:	NP_000944.1	Gene:	PTGDR / 5729	HGNCID:	9591	Length:	359	Species:	Homo sapiens

Alignment Length:	398	Identity:	104/398 - (26%)
Similarity:	158/398 - (39%)	Gaps:	125/398 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 NSTTVAPPKALYANRNRLIIGVIIMVLGVFGNSLALFILARKKLNKNSKYTLMLRCLATNNLVAL 79
            |:|:|       ...|..::|.::...|:.||.|||.:|||..|...|:..  ||.|.:...:.:
Human    10 NTTSV-------EKGNSAVMGGVLFSTGLLGNLLALGLLARSGLGWCSRRP--LRPLPSVFYMLV 65

  Fly    80 LGMLTTTLL-KMYLSKEVLQSF-----IRVDCVGL---------VVWRFFGLSSGCIAAVMAAER 129
            .|:..|.|| |..||..||.::     :||....|         ....||||||......||.|.
Human    66 CGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMSFFGLSSTLQLLAMALEC 130

  Fly   130 WMALARPFIYHKHITYELIRKSINSILMIAVVITF------LPFVGFGAYIDESNPDQLKCIRYR 188
            |::|..||.|.:|||..|      ..|:..||..|      |||:|||           |.::|
Human   131 WLSLGHPFFYRRHITLRL------GALVAPVVSAFSLAFCALPFMGFG-----------KFVQY- 177

  Fly   189 DAPGVW--------NKTYAVL--FMVFGTLLCIVIVACNLFVAHTLLCVIGRSRTAKRHMHYDLV 243
             .||.|        ..:.:||  .:::.:|:.::::|       |:||.:|..|
Human   178 -CPGTWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLA-------TVLCNLGAMR----------- 223

  Fly   244 SRDKNSAISIDPESSSGTTLYQTQLSTGSGNSHRSVQPARQYRHSVSVTMAAT-------DSSP- 300
                              .||.         .||.:|     ||..|.|....       ::||
Human   224 ------------------NLYA---------MHRRLQ-----RHPRSCTRDCAEPRADGREASPQ 256

  Fly   301 --VEIKFAKLMAFLSISFVICWMPQMIAIPLAIAPNRVPASNKFFIIADVLTALHFTS-----DP 358
              .|:....|:|.:::.|.:|.:| :|......|...|...|:....|:.|.||.|.|     ||
Human   257 PLEELDHLLLLALMTVLFTMCSLP-VIYRAYYGAFKDVKEKNRTSEEAEDLRALRFLSVISIVDP 320

  Fly   359 YVYVLSRS 366
            :::::.||
Human   321 WIFIIFRS 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7497	NP_001287100.1	7tm_4	36..>221	CDD:304433	63/215 (29%)
PTGDR	NP_000944.1	7tmA_PGD2	17..335	CDD:320268	101/384 (26%)
		TM helix 1	18..44	CDD:320268	10/25 (40%)
		TM helix 2	61..87	CDD:320268	9/25 (36%)
		TM helix 3	105..135	CDD:320268	10/29 (34%)
		TM helix 4	147..169	CDD:320268	7/27 (26%)
		TM helix 5	195..224	CDD:320268	9/64 (14%)
		TM helix 6	258..288	CDD:320268	7/30 (23%)
		TM helix 7	302..327	CDD:320268	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I11441
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	71	1.000	Inparanoid score	I5311
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D412827at33208
OrthoFinder	1	1.000	-	-		FOG0000857
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11866
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10330
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	7.100