DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7497 and Ptgfr

DIOPT Version :9

Sequence 1:	NP_001287100.1	Gene:	CG7497 / 39966	FlyBaseID:	FBgn0036742	Length:	412	Species:	Drosophila melanogaster
Sequence 2:	NP_037247.1	Gene:	Ptgfr / 25652	RGDID:	3436	Length:	366	Species:	Rattus norvegicus

Alignment Length:	352	Identity:	80/352 - (22%)
Similarity:	140/352 - (39%)	Gaps:	83/352 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 NRNRLIIGVIIMVLGVFGNSLALFIL--ARKKLNKNSKYTLMLRCLATNNLVA-LLGMLTT--TL 87
            ||..:...:|.|.:|:..||||:.||  |.::..:.||.:.:|  ||:..::. ..|.|..  ..
  Rat    26 NRLSVFFSIIFMTVGIVSNSLAIAILMKAYQRFRRKSKASFLL--LASGLVITDFFGHLINGGIA 88

  Fly    88 LKMYLSKEVLQSFIRVDCVGLVVWRFFGLS---SG-C---IAAVMAAERWMALARPFIYHKHITY 145
            :.:|.|.   :.:||.| ...::...||:|   || |   :.:.||.||.:.:..|..:...||.
  Rat    89 VFVYASD---KDWIRFD-QSNILCSVFGISMVFSGLCPLFLGSTMAIERCIGVTNPLFHSTKITS 149

  Fly   146 ELIRKSINSILMIAVVITFLPFVGFGAYIDESNPDQLKCIRYRDAPGVW-NKTYAVLFMVFGTLL 209
            :.::..::.:.|.||.:..||.:|...|  :....:..|....:....| ::.|.:.|...|.|.
  Rat   150 KHVKMILSGVCMFAVFVALLPILGHRDY--QIQASRTWCFYNTEHIEDWEDRFYLLFFSSLGLLA 212

  Fly   210 CIVIVACNLFVAHTLLCVIGRSRTAKRHMHYDLVSRDKNSAISIDPESSSGTTLYQTQLSTGSGN 274
            ..:..:||.....|||.|..||:..::                                    |.
  Rat   213 LGISFSCNAVTGVTLLRVKFRSQQHRQ------------------------------------GR 241

  Fly   275 SHRSVQPARQYRHSVSVTMAATDSSPVEIKFAKLMAFLSISFVICWMPQMIAIP-LAIAPNRVPA 338
            ||          |...|              .:|:|.:.:| .:||.|.::.:. :||..|..|.
  Rat   242 SH----------HLEMV--------------IQLLAIMCVS-CVCWSPFLVTMANIAINGNNSPV 281

  Fly   339 SNKFFIIADVLTALHFTSDPYVYVLSR 365
            :.:..:.|..:...:...||:||:|.|
  Rat   282 TCETTLFALRMATWNQILDPWVYILLR 308

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7497	NP_001287100.1	7tm_4	36..>221	CDD:304433	50/197 (25%)
Ptgfr	NP_037247.1	7tmA_FP	27..316	CDD:320273	79/351 (23%)
		TM helix 1	29..53	CDD:320273	9/23 (39%)
		TM helix 2	67..89	CDD:320273	5/23 (22%)
		TM helix 3	109..131	CDD:320273	7/21 (33%)
		TM helix 4	154..170	CDD:320273	3/15 (20%)
		TM helix 5	198..221	CDD:320273	5/22 (23%)
		TM helix 6	248..270	CDD:320273	7/36 (19%)
		TM helix 7	283..308	CDD:320273	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338662
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D412827at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11866
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.950