DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment anchor and Gpr155

DIOPT Version :9

Sequence 1:	NP_001261995.1	Gene:	anchor / 39965	FlyBaseID:	FBgn0036741	Length:	957	Species:	Drosophila melanogaster
Sequence 2:	NP_001101281.1	Gene:	Gpr155 / 311730	RGDID:	1309162	Length:	868	Species:	Rattus norvegicus

Alignment Length:	968	Identity:	319/968 - (32%)
Similarity:	494/968 - (51%)	Gaps:	146/968 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDSSMYYASQRIAASTEANVRVITSTMASSLA-NGTATPRADDGGVSMNNFYPALVQCFGIIICG 64
            |||  |:.::....:...|     .|:::|.. |.|:.|..    :|:...:|||::||||::||
  Rat     1 MDS--YFPAKNSTLAVNMN-----ETLSASHGFNSTSDPPP----MSITRLFPALLECFGIVLCG 54

  Fly    65 YIAGRFKIISNAETKGLGTFVGTFALPSLIFLSLVELNWSAVNWSFLLAMLVSKAVVFFAVLIIS 129
            |||||..:|::.:.||||.||..||||:|:|.::|.||::.|:|:||.::|:.||.|||.|.:::
  Rat    55 YIAGRANVITSTQAKGLGNFVSRFALPALLFKNMVVLNFANVDWAFLYSILIGKASVFFVVCVLT 119

  Fly   130 LLVARP-LNYARGGLMAIFCTQSNDFAIGYPIVMALYKDVHPEYASYLYLMAPISLAILNPVGLV 193
            ||||.| ..:::.||..||.|||||||:|||||.|||:..:|||..|:||:|||||.:|||:|.:
  Rat   120 LLVASPESRFSKAGLFPIFATQSNDFALGYPIVEALYQTTYPEYLQYIYLVAPISLMMLNPIGFI 184

  Fly   194 LMEISKIIKNKEDVTRNPPLCPETCPAEQMSKRNRCLGERSILVFNTLIALFFNPLLLMTLLGVA 258
            ..||.   |:|:  |||         |.|...:...||         .:.:..||::.|..:|:|
  Rat   185 FCEIQ---KSKD--TRN---------ASQNKAKIVGLG---------FLRVLQNPIVFMVFVGIA 226

  Fly   259 GGFLFPNGLPEMVSSTLRVLGQSFSATALFLLGLKIVGGTGSERKSIGFLLPGVLILVKILVLPL 323
            ..|:....:|..:.:.|..|..|||.:|||.|||.:||.....:|| .|:...|||..|:|||||
  Rat   227 FNFILDKKIPVYMENFLDGLANSFSGSALFYLGLTMVGKIRRLKKS-AFVALIVLITAKLLVLPL 290

  Fly   324 VIRQTVNIMQSGQNFNDTTELSTFGFLYGTFPAAPGAFVIATQYNMEVELVARSMVFCTFISAPL 388
            :.|:.|.::..|.:..:.|.||.:.||||.||.|||..:.|||:|||||::...||..||:|||:
  Rat   291 LCREMVEVLDKGNSVVNHTSLSNYAFLYGVFPVAPGVAIFATQFNMEVEIITSGMVISTFVSAPI 355

  Fly   389 MFISAKMISLTNL--KPLDYLHELDAFSFDISVAGAAACCIMLALLIVTKRFKRMPQRITFCLVL 451
            |::||.:::...:  |||.|  .:...|||||:....:....|::|:::|::|::|..:|..|::
  Rat   356 MYVSAWLLTFPTMDAKPLAY--AIQNVSFDISIISLVSLIWSLSVLLLSKKYKQLPHMLTANLLI 418

  Fly   452 SQLMCCIGVILWSKMEHVHRWPLYLQFLLFNIGTYSTRLWTGLLAISLLFLQCR-SLCFVLKLWP 515
            :|.:.|.|:::|:.::..:.....|.|:|.....|||.|||||||:||..|:.| |:...:.|
  Rat   419 AQTIVCAGMVIWNFVKEKNFVGQILVFVLLYSSLYSTYLWTGLLAVSLFLLKKRESVQIPVGL-- 481

  Fly   516 YMLVFAWGVPAVLSALLIAFDSNVMSGEKHNPSFQYGNAQ---AAISVFMLVMCFIVTVGCLVLH 577
             :::..||:||:|..:|:....:  :|:..:.:|.||..|   .|:::|..::...|::.|:
  Rat   482 -IIISGWGIPALLVGVLLITGKH--NGDSVDSAFFYGKEQMITTAVTLFCSILIAGVSLMCM--- 540

  Fly   578 QRYKKRYEKYMTYSRELSNPESESSDLHSTISTTNLLSHTDQSSIRQSVRTASYSSSSDDEEMIP 642
                                           :.|....|.:.....||.:.....|::.:|...|
  Rat   541 -------------------------------NRTTQAGHYEGFGQSQSHKPVEPGSTAFEESPAP 574

  Fly   643 TAAG--LPTS-RSNGAASGGAGSGGGGCGSGNGTC-CSGGAPVSNSSTTSTVVVDIEDLLNRTRQ 703
            |:..  .|:| ...|..|         |..|||.. |....|.:|||.              :|.
  Rat   575 TSEPELFPSSIPETGCCS---------CSLGNGELRCPSIQPGTNSSA--------------SRP 616

  Fly   704 RASGANNKDLNKIESAPATEEIRNQMCSSSFNCGPSTSRQSCQTIIERYEDQNRRGLEPLEHPSD 768
            |.|.....|                      .|......|||  |:.:.|:|..:..:|
  Rat   617 RPSSFEKTD----------------------QCVSRCDSQSC--ILAQEEEQYLQSGDP------ 651

  Fly   769 ADEHQTLKHTVLLITLLCSMFVGLAVSIWTLVMEGMSGIYLELSFLDAFLNFGQGLIVLAVFITD 833
                |..:|.:|.:.|:..:|..|:..:|.|.......:|:||.|..|..|||||.|...:|..|
  Rat   652 ----QLTRHVLLCLLLIIGLFANLSSCLWWLFNHETGRLYVELQFFCAVFNFGQGFISFGIFGLD 712

  Fly   834 IGELLMPVVKLWRKLWYGANVVSLPHWSNVRPETKHICEQFRNHHLENCKKDIAKDRRWRIRVYR 898
            ...:::|..:....||....... ...|.|..|.|..|:||.::|.:.|.::|.::||...:...
  Rat   713 KHLIILPFKRRLEFLWNNKETAE-DRESPVSEEIKMTCQQFVHYHRDLCIRNIVRERRCGAKTSA 776

  Fly   899 RVFYGTEFVSWLIEVGLSKDRMEAVHYARHLVDGRVLRHINNVYHFEDKLLLYNFCSR 956
            ..|.|.:.|:|||||||:.||.|||.|...||.|.|::||.|.|.|.|:.|.|.|..:
  Rat   777 GTFCGCDLVNWLIEVGLASDRGEAVIYGDRLVQGGVIQHITNEYEFRDEYLFYRFLQK 834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
anchor	NP_001261995.1	Mem_trans	53..387	CDD:304621	150/334 (45%)
anchor	NP_001261995.1	DEP_GPR155	871..953	CDD:239890	36/81 (44%)
Gpr155	NP_001101281.1	Mem_trans	36..364	CDD:304621	157/351 (45%)
		7tm_4	387..>507	CDD:304433	37/124 (30%)
		DEP_GPR155	749..831	CDD:239890	36/81 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335176
Domainoid	1	1.000	174	1.000	Domainoid score	I3579
eggNOG	1	0.900	-	-		E1_2BZ3U
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H16584
Inparanoid	1	1.050	476	1.000	Inparanoid score	I1428
OMA	1	1.010	-	-		QHG49861
OrthoDB	1	1.010	-	-		D123487at33208
OrthoFinder	1	1.000	-	-		FOG0006319
OrthoInspector	1	1.000	-	-		oto95688
orthoMCL	1	0.900	-	-		OOG6_106133
Panther	1	1.100	-	-	LDO	PTHR22829
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4600
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770