DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment anchor and gpr155

DIOPT Version :9

Sequence 1:	NP_001261995.1	Gene:	anchor / 39965	FlyBaseID:	FBgn0036741	Length:	957	Species:	Drosophila melanogaster
Sequence 2:	XP_012826669.1	Gene:	gpr155 / 100497376	XenbaseID:	XB-GENE-985430	Length:	843	Species:	Xenopus tropicalis

Alignment Length:	948	Identity:	320/948 - (33%)
Similarity:	482/948 - (50%)	Gaps:	150/948 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 MASSLANGTATPRADDGGVSM--NNFYPALVQCFGIIICGYIAGRFKIISNAETKGLGTFVGTFA 89
            |.:...:|.....|..|..||  |..:|||::|||||:|||||||..|||..:.||||.:|..||
Frog    18 MTNMFGDGADQANATGGSTSMSINRLFPALLECFGIIMCGYIAGRANIISATQAKGLGNYVSRFA 82

  Fly    90 LPSLIFLSLVELNWSAVNWSFLLAMLVSKAVVFFAVLIISLLVARP-LNYARGGLMAIFCTQSND 153
            ||:|:|.::|.|::|.||||||.::|::||.||..|.:::||||.| ..:::.||..||.|||||
Frog    83 LPALLFKNMVVLDFSDVNWSFLYSILIAKASVFVIVCVLTLLVANPQTRFSKAGLFPIFATQSND 147

  Fly   154 FAIGYPIVMALYKDVHPEYASYLYLMAPISLAILNPVGLVLMEISKIIKNKEDVTRNPPLCPETC 218
            ||:|||||.|||:..:|:|..|:||:||:||.:|||:|.||.||.|...|           |.|.
Frog   148 FALGYPIVEALYQTTYPKYLQYIYLVAPVSLMMLNPLGFVLCEIQKWKDN-----------PNTS 201

  Fly   219 PAEQMSKRNRCLGERSILVFNTLIALFFNPLLLMTLLGVAGGFLFPNGLPEMVSSTLRVLGQSFS 283
            .:           :..||.| .|:.:|.||::.|..:|:|..|:....:|..:.:.|..|..|||
Frog   202 HS-----------KLKILGF-ALLRVFQNPIVFMVFIGIAFNFVLGQKIPIYLENFLDGLASSFS 254

  Fly   284 ATALFLLGLKIVGGTGSERKSIGFLLPGVLILVKILVLPLVIRQTVNIMQSGQNFNDTTELSTFG 348
            ..|||.|||.:||.||...|| .|:...:||..|:|||||:.|:.|.::....:..:.|.|:.:.
Frog   255 GAALFYLGLTMVGQTGKLEKS-SFVALLLLITAKLLVLPLICRELVELLDKTSDVVNHTSLTNYA 318

  Fly   349 FLYGTFPAAPGAFVIATQYNMEVELVARSMVFCTFISAPLMFISAKMISLTNLKPLDYLHELDAF 413
            ||||.||.|||..:.|.|:|||:|::...||..||:|||:|::||.::::.::.|...:..|...
Frog   319 FLYGVFPVAPGVVIFAGQFNMELEIITPGMVISTFVSAPIMYVSAWLLTIPSMDPKPLVAALQNV 383

  Fly   414 SFDISVAGAAACCIMLALLIVTKRFKRMPQRITFCLVLSQLMCCIGVILWSKMEHVHRWPLYLQF 478
            |||||:.........||:|:::|::||:|..:|..|:||||:.|:|::||:.:  :....:..|.
Frog   384 SFDISILSILCLIWSLAVLLLSKKYKRLPHLLTSNLLLSQLITCVGMVLWNFI--IQERNVVGQI 446

  Fly   479 LLFNI---GTYSTRLWTGLLAISLLFLQCRSLCFVLKLWPYMLVFA-WGVPAVLSALLIAFDSNV 539
            |:|.|   ..||:..|||||::||:.|:.|.    .|:....||.| ||||.::..:|::
Frog   447 LVFVILYSALYSSYFWTGLLSLSLVLLKKRD----GKVPVVFLVLAGWGVPVLVVCILLS----- 502

  Fly   540 MSGEKH----NPSFQYGNAQAAISVFMLVMCFIVTVGCLVLHQRYKKRYEKYMTYSRELSNPESE 600
             :||:.    :.:|.||.:|        ::|..|.:.|.:|....     ..|..||     ..:
Frog   503 -AGERDLDSIDSAFFYGTSQ--------IICTAVILSCSILLSGI-----SLMCMSR-----SGQ 548

  Fly   601 SSDLHSTISTTNLLSHTDQSSIRQSVRTASYSSSSDDEEMIPTAAGLPTSRSNGAASGGAGSGGG 665
            ..:.|       :|.|:.|::..:||.  :...|..|...:.:.:.|.|.|...|
Frog   549 DGNYH-------VLLHSSQNNSNRSVN--NMEDSKPDSPTLASTSSLSTERDFCA---------- 594

  Fly   666 GCGSGNGTCCSGGAPVSNSSTTSTVVVDIEDLLNRTRQRASGANNKDLNKIESAPATEEIRNQMC 730
             |...||..|    |...|:|.                         || |.:.|:.||
Frog   595 -CNKENGDVC----PSVESATA-------------------------LN-INTPPSIEE------ 622

  Fly   731 SSSFNCGPSTSRQSCQTIIERYEDQNRRGLEPLEHPSDADEHQTLKHTVLLITLLCSMFVGLAVS 795
              :..|....:.|.|  ::.:.|.|...|           :.|..:|.:|.:.|:..:...::..
Frog   623 --AHECLTRCNTQRC--LLSQEEQQINSG-----------DGQMARHVLLCLFLVVGLLANVSSC 672

  Fly   796 IWTLVMEGMSGIYLELSFLDAFLNFGQGLIVLAVFITDIGELLMPVVKLWRKLWYGANVVSLPHW 860
            .|.|.......:|:||.|..|..|||||||..|:|..|...:::|..|....||....
Frog   673 FWWLFNREPGRLYVELQFFCAVFNFGQGLISFAIFGLDKHLIILPCKKRLEFLWNSRE------- 730

  Fly   861 SNVRPETKHI-------CEQFRNHHLENCKKDIAKDRRWRIRVYRRVFYGTEFVSWLIEVGLSKD 918
            |||..|...:       |.||..:|.:.|.::|.|:||...|....||:|::.||||:||||:.|
Frog   731 SNVNAEEARLPEDIRMTCHQFVQYHKDLCIRNIVKERRCGARTSPGVFWGSDLVSWLVEVGLAPD 795

  Fly   919 RMEAVHYARHLVDGRVLRHINNVYHFEDKLLLYNFCSR 956
            |.|||.|...|:.|.|::||.:.|.|.|:...|....:
Frog   796 RGEAVKYGERLLKGGVIQHITDEYEFRDENFYYRMLKK 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
anchor	NP_001261995.1	Mem_trans	53..387	CDD:304621	150/334 (45%)
anchor	NP_001261995.1	DEP_GPR155	871..953	CDD:239890	36/81 (44%)
gpr155	XP_012826669.1	Mem_trans	39..369	CDD:328943	157/353 (44%)
		7tm_GPCRs	388..>524	CDD:391938	48/155 (31%)
		TM helix 2	413..434	CDD:341315	9/20 (45%)
		TM helix 3	446..464	CDD:341315	6/17 (35%)
		TM helix 4	484..500	CDD:341315	7/15 (47%)
		DEP_GPR155	748..830	CDD:239890	36/81 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	167	1.000	Domainoid score	I3818
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H16584
Inparanoid	1	1.050	455	1.000	Inparanoid score	I1539
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123487at33208
OrthoFinder	1	1.000	-	-		FOG0006319
OrthoInspector	1	1.000	-	-		oto102426
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4600
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.060