DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vps60 and chmp5a

DIOPT Version :9

Sequence 1:	NP_001261994.1	Gene:	Vps60 / 39964	FlyBaseID:	FBgn0036740	Length:	226	Species:	Drosophila melanogaster
Sequence 2:	XP_686934.2	Gene:	chmp5a / 558613	ZFINID:	ZDB-GENE-060503-60	Length:	251	Species:	Danio rerio

Alignment Length:	222	Identity:	128/222 - (57%)
Similarity:	167/222 - (75%)	Gaps:	3/222 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNRLFGRGKPKEPGPSLNDCIAGVDARATNIEEKISNLEAELRKYREQMSKMREGPAKNSVKQKA 65
            |||:|||.| :...|:|:|||..||.|..:|::||:.::|||.||::||.|||:||:||:|||||
Zfish    33 MNRIFGRSK-QAASPNLSDCIGNVDTRIESIDKKIARIDAELMKYKDQMKKMRDGPSKNTVKQKA 96

  Fly    66 LRVLKQKKAYEQQAESLRNQSFNMEQANYAAQSLKDTQATVAAMKDGVKQMKTEYKKINIDQIED 130
            :||||||:.||.|.:.|..||||||||||..|||:||:.||.|||.|.|:||..||::.:|||||
Zfish    97 MRVLKQKRMYEGQRDQLSQQSFNMEQANYTIQSLRDTKTTVEAMKIGAKEMKKAYKQVKMDQIED 161

  Fly   131 IQDDMADMFEQADEVQEALGRTYGMPEVDDDDLQAELDALGDEIALDDDTSYLDDVVKAPEAPSR 195
            :||.:.||.|:|:||||||.|:||.||:|:|:|:|||||||||:.||||:||||:...||..|..
Zfish   162 LQDQLEDMMEEANEVQEALSRSYGTPEIDEDELEAELDALGDELLLDDDSSYLDEASSAPSIPEG 226

  Fly   196 EPGADSIVPGKSTIETDEFGLPKIPTS 222
            .|  ......|..:..||||||:||.:
Zfish   227 MP--SDTKTNKDGVLVDEFGLPQIPAT 251

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps60	NP_001261994.1	Snf7	1..190	CDD:304451	115/188 (61%)
chmp5a	XP_686934.2	Snf7	33..238	CDD:328813	120/207 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581736
Domainoid	1	1.000	246	1.000	Domainoid score	I2132
eggNOG	1	0.900	-	-		E1_KOG1655
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	283	1.000	Inparanoid score	I2856
OMA	1	1.010	-	-		QHG53573
OrthoDB	1	1.010	-	-		D1301560at2759
OrthoFinder	1	1.000	-	-		FOG0003367
OrthoInspector	1	1.000	-	-		otm25220
orthoMCL	1	0.900	-	-		OOG6_102352
Panther	1	1.100	-	-	O	PTHR22761
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2003
SonicParanoid	1	1.000	-	-		X3249
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800