DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eip74EF and Elf2

DIOPT Version :9

Sequence 1:	NP_001014590.1	Gene:	Eip74EF / 39962	FlyBaseID:	FBgn0000567	Length:	883	Species:	Drosophila melanogaster
Sequence 2:	NP_075991.1	Gene:	Elf2 / 69257	MGIID:	1916507	Length:	593	Species:	Mus musculus

Alignment Length:	335	Identity:	127/335 - (37%)
Similarity:	163/335 - (48%)	Gaps:	77/335 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   568 GGTQPGGPGNPQTPGYLTTSYFNAPTAATAAASQRGTTINGYHSLHQQQQQQQQSQQSQQQQQLA 632
            |..|.||...|..|..:...   .|:|                               :.:|..|
Mouse    20 GENQEGGDTGPDCPAVIVEP---VPSA-------------------------------RLEQGYA 50

  Fly   633 HQQLSHQQQQALHQQLSHQQQQQQQQQQQHPHSQLNGPHPHSHPHSHPHSHPHAGQHTHSTIAAA 697
            .|.|.:..:..:.|.::.:|:.:.:          |.....:..||   |:.|.   |..||.||
Mouse    51 AQVLVYDDETYMMQDVAEEQEVETE----------NSETVEASVHS---SNAHC---TDKTIEAA 99

  Fly   698 AA---AAAASVVSSSSSAVAAAAMLSASAAAAATAAAAAGGSQSVIQPATSSVSYDLSYMLELGG 759
            .|   ..:.:.:..|.|.|........|......||.    ...||......||.:.|..::...
Mouse   100 EALLHMESPTCLRDSRSPVEVFVPPCISTPEFIHAAM----RPDVITETVVEVSTEESEPMDASP 160

  Fly   760 F--------QQRKAKKPRKPKL----------EMGVKRRSRE--GSTTYLWEFLLKLLQDREYCP 804
            .        ..:|.|..||||.          |:|:|:::||  |:|||||||||.||||:..||
Mouse   161 IPTSPDSHEPMKKKKVGRKPKTQQSPVSNGSPELGIKKKAREGKGNTTYLWEFLLDLLQDKNTCP 225

  Fly   805 RFIKWTNREKGVFKLVDSKAVSRLWGMHKNKPDMNYETMGRALRYYYQRGILAKVDGQRLVYQFV 869
            |:||||.||||:||||||||||:|||.||||||||||||||||||||||||||||:||||||||.
Mouse   226 RYIKWTQREKGIFKLVDSKAVSKLWGKHKNKPDMNYETMGRALRYYYQRGILAKVEGQRLVYQFK 290

  Fly   870 DVPKDIIEID 879
            |:||:|:.||
Mouse   291 DMPKNIVVID 300

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eip74EF	NP_001014590.1	Ets	789..869	CDD:278602	69/79 (87%)
Elf2	NP_075991.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34		5/13 (38%)
		Elf-1_N	3..108	CDD:403506	25/137 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	146..199		12/52 (23%)
		Ets	209..289	CDD:395126	69/79 (87%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	362..383
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	155	1.000	Domainoid score	I4218
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006321
OrthoInspector	1	1.000	-	-		otm42817
orthoMCL	1	0.900	-	-		OOG6_106781
Panther	1	1.100	-	-	O	PTHR11849
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3979
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.940