DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eip74EF and AgaP_AGAP007327

DIOPT Version :9

Sequence 1:	NP_001014590.1	Gene:	Eip74EF / 39962	FlyBaseID:	FBgn0000567	Length:	883	Species:	Drosophila melanogaster
Sequence 2:	XP_564896.3	Gene:	AgaP_AGAP007327 / 3290353	VectorBaseID:	AGAP007327	Length:	763	Species:	Anopheles gambiae

Alignment Length:	818	Identity:	315/818 - (38%)
Similarity:	398/818 - (48%)	Gaps:	198/818 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   204 LDDVSKILWERKQQLQRSSVITAAPTLQPQQHQQPMSDIED--------EETLEDVDDADADVEA 260
            :||  ::||.....   ..::.....||.:.:|...|...:        ||.||  :|:|..:..
Mosquito     4 IDD--ELLWSPDND---GRMVDLQACLQTESNQATASQTAELASELNTLEEQLE--NDSDELLRQ 61

  Fly   261 DAEDEELLEQY------------QNGYDSPLDLSLGG----------ATSAAASAAAAASAVSRR 303
            ..|:...|||:            :|..|..||....|          .|||||:|..:|.:|
Mosquito    62 LTENTFELEQFFQDFPATEIKVEENNNDLQLDEETNGQIFLQNCSQFLTSAAAAAQLSALSV--- 123

  Fly   304 RGRTYSGTESDD-----SAQCERARMRLKPERKAERSAAYKKSLMKRYYTEIPIVKQSTSPAPQQ 363
                   ||.:|     ...|.....:|............::.|:.:....:...:.:.|...::
Mosquito   124 -------TEPNDLDGGLQRLCSGGNDQLVGSGGLTTQQLQEQILLAQAQGLLQQNRFNNSLLAEK 181

  Fly   364 QLQQQHHLQQQQQQQPHNGSTFAGATALLHIKTEQNTLLTPLQLQQQQQQQQGLHGAAGNGGSSN 428
            .||..||.|||||||.|          |.|..|.....:|.|       ...|:..::.:|||:|
Mosquito   182 LLQNHHHHQQQQQQQLH----------LHHTHTNSQNGVTSL-------DALGVPSSSSSGGSNN 229

  Fly   429 GNNAHQQ------------------------------QQPLAIPQ-------------------- 443
            |||.|..                              |.|...||
Mosquito   230 GNNHHSSSNGSSSSNGGRANKPPDIVIKVDTEIPILPQSPSPPPQQRSSLAGGQSQQTASLLAST 294

  Fly   444 -------RPLLHNLLSGGAI-HNPHHRNYTTATTGSFPPSPADSGVSDVDSSSSGGQP-CADELK 499
                   |||||.||||..: ..|:||.|:|::|||.||||||||||||||||||||| |:||||
Mosquito   295 LQPSQQHRPLLHGLLSGTHLPQGPYHRGYSTSSTGSLPPSPADSGVSDVDSSSSGGQPACSDELK 359

  Fly   500 ARLGM-------------------------------PPATS-ASAAAAAAAAAAAAAHLHTGTFL 532
            ||||:                               |.||| :|::|.:..||||||||.:|.||
Mosquito   360 ARLGIPTSSTGPVSNQPGQPSTRSRVNRSRCTRMAGPSATSLSSSSALSQVAAAAAAHLQSGPFL 424

  Fly   533 HPNLYQNNAANSLRNIWNRSVGVPDNYYGSSGAGSGGTQPGGPGNPQTPGYLTTSYFNAPTAATA 597
            .||.| ::::..||||||:....||.||.....|:......|..:|:...|.|.:........|.
Mosquito   425 RPNFY-HHSSPPLRNIWNQRSYAPDTYYSVLRCGAMVPYCAGRNSPRKVAYQTIARIEEAARCTR 488

  Fly   598 AASQRGTTINGYHSLHQQQQQQQQSQQSQQQQQLAHQQLSHQQQQALHQQLSHQQQQQQQQQQQH 662
            .||..........||....::|:::.:|...:||  ::|.|:......:..:.:.:.:....:..
Mosquito   489 NASANARAWLAEISLRTTDEKQERNGRSIFMEQL--ERLLHETSAERAELATSETKSRTTHDKTT 551

  Fly   663 PHSQLNGPHPHSHPHSHPHSHPHAGQ------HTHSTIAAAAAAAAASVVSSSSSAVAAAAMLSA 721
            ||..|..||...:|:.|.|. .|.||      |.|        |.:..||...::        ||
Mosquito   552 PHGHLAAPHHAGNPNGHHHG-AHLGQQHGLGHHGH--------AGSGHVVGGGAN--------SA 599

  Fly   722 SAAAAATAAAAAG-------GSQSVIQPATSSVSYDLSYMLELGGFQQRKAKKPRKPKLEMGVKR 779
            :|||||..|...|       |..||    :||...|||||||| |||.||.|||:||||||||||
Mosquito   600 AAAAAALMANGIGLGHHGQHGPHSV----SSSCPDDLSYMLEL-GFQPRKLKKPKKPKLEMGVKR 659

  Fly   780 RSREGSTTYLWEFLLKLLQDREYCPRFIKWTNREKGVFKLVDSKAVSRLWGMHKNKPDMNYETMG 844
            :||||||||||||||||||||||||||||||||:|||||||||||||:|||||||||||||||||
Mosquito   660 KSREGSTTYLWEFLLKLLQDREYCPRFIKWTNRDKGVFKLVDSKAVSKLWGMHKNKPDMNYETMG 724

  Fly   845 RALRYYYQRGILAKVDGQRLVYQFVDVPKDIIEIDCNG 882
            |||||||||||||||||||||||||||||||:||||.|
Mosquito   725 RALRYYYQRGILAKVDGQRLVYQFVDVPKDIVEIDCTG 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eip74EF	NP_001014590.1	Ets	789..869	CDD:278602	77/79 (97%)
AgaP_AGAP007327	XP_564896.3	HIP1_clath_bdg	31..100	CDD:293123	17/70 (24%)
AgaP_AGAP007327	XP_564896.3	Ets	669..749	CDD:278602	77/79 (97%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	235	1.000	Domainoid score	I5271
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	428	1.000	Inparanoid score	I3688
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006321
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11849
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X15135
TreeFam	0	0.000	Not matched by this tool.
	7	7.060