DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eip74EF and GABPA

DIOPT Version :9

Sequence 1:	NP_001014590.1	Gene:	Eip74EF / 39962	FlyBaseID:	FBgn0000567	Length:	883	Species:	Drosophila melanogaster
Sequence 2:	NP_001184226.1	Gene:	GABPA / 2551	HGNCID:	4071	Length:	454	Species:	Homo sapiens

Alignment Length:	122	Identity:	51/122 - (41%)
Similarity:	71/122 - (58%)	Gaps:	14/122 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   763 RKAKKPRKPKLEMGVKRRSREGSTT------YLWEFLLKLLQDREY--CPRFIKWTNREKGVFKL 819
            :.||..|.|::  ..:.||..|:.|      .||:|||:||.|::.  |   |.|.. ::|.|||
Human   292 KAAKVQRAPRI--SGEDRSSPGNRTGNNGQIQLWQFLLELLTDKDARDC---ISWVG-DEGEFKL 350

  Fly   820 VDSKAVSRLWGMHKNKPDMNYETMGRALRYYYQRGILAKVDGQRLVYQFVDVPKDII 876
            ...:.|::.||..||||.||||.:.|||||||...::.||.|:|.||:||...|.:|
Human   351 NQPELVAQKWGQRKNKPTMNYEKLSRALRYYYDGDMICKVQGKRFVYKFVCDLKTLI 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eip74EF	NP_001014590.1	Ets	789..869	CDD:278602	39/81 (48%)
GABPA	NP_001184226.1	GABP-alpha	40..119	CDD:402975
		SAM_PNT-GABP-alpha	168..254	CDD:176084
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..316		6/20 (30%)
		ETS	319..403	CDD:197710	41/87 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910