DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eip74EF and ELF4

DIOPT Version :9

Sequence 1:	NP_001014590.1	Gene:	Eip74EF / 39962	FlyBaseID:	FBgn0000567	Length:	883	Species:	Drosophila melanogaster
Sequence 2:	NP_001120669.1	Gene:	ELF4 / 2000	HGNCID:	3319	Length:	663	Species:	Homo sapiens

Alignment Length:	221	Identity:	99/221 - (44%)
Similarity:	123/221 - (55%)	Gaps:	33/221 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   686 AGQHTHSTIAAAAAAAAASVVSSSSSAVAAAAMLSASAAAAATAAAAAGGSQSVIQPAT------ 744
            |..||.||........:.|.:.......:.:.||..|..|.|...      .:.:.||:
Human    87 ATSHTMSTAEVLLNMESPSDILDEKQIFSTSEMLPDSDPAPAVTL------PNYLFPASEPDALN 145

  Fly   745 --SSVSYDLSYMLELGGFQQRKAKKPRK-------------------PKLEMGVKRRSREGSTTY 788
              ...|....:.||....::..|||..|                   |.:.:..|.:..:|||.|
Human   146 RAGDTSDQEGHSLEEKASREESAKKTGKSKKRIRKTKGNRSTSPVTDPSIPIRKKSKDGKGSTIY 210

  Fly   789 LWEFLLKLLQDREYCPRFIKWTNREKGVFKLVDSKAVSRLWGMHKNKPDMNYETMGRALRYYYQR 853
            ||||||.|||||..||::||||.||||:||||||||||:|||..|||||||||||||||||||||
Human   211 LWEFLLALLQDRNTCPKYIKWTQREKGIFKLVDSKAVSKLWGKQKNKPDMNYETMGRALRYYYQR 275

  Fly   854 GILAKVDGQRLVYQFVDVPKDIIEID 879
            ||||||:||||||||.::|||::.|:
Human   276 GILAKVEGQRLVYQFKEMPKDLVVIE 301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eip74EF	NP_001014590.1	Ets	789..869	CDD:278602	68/79 (86%)
ELF4	NP_001120669.1	Elf-1_N	2..104	CDD:315071	5/16 (31%)
		RUNX1-binding. /evidence=ECO:0000269\|PubMed:10207087	87..206		22/124 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	140..203		9/62 (15%)
		ETS	208..290	CDD:197710	69/81 (85%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	302..353		99/221 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	493..518
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	582..605
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	635..663
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	155	1.000	Domainoid score	I4215
eggNOG	1	0.900	-	-		E1_KOG3804
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40744
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11849
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.870