Protein Alignment CycT and CCNT2

DIOPT Version :10

• Sequence 1: NP_524127.2
• Gene: CycT / 39961
• FlyBaseID: FBgn0025455
• Length: 1097
• Species: Drosophila melanogaster
• Sequence 2: NP_490595.1
• Gene: CCNT2 / 905
• HGNCID: 1600
• Length: 730
• Species: Homo sapiens
• Alignment Length: 1028
• Identity: 301/1028 - (29%)
• Similarity: 406/1028 - (39%)
• Gaps: 398/1028 - (38%)

  Fly    45 WYFSNDQLANSPSRRCGIKGDDELQYRQMTAYLIQEMGQRLQVSQLCINTAIVYMHRFYAFHSFT 109
            |:|:.:||.|:||||||::.|.||..||..|.|||||||||.||||.||||||||||||..||||
Human    11 WFFTREQLENTPSRRCGVEADKELSCRQQAANLIQEMGQRLNVSQLTINTAIVYMHRFYMHHSFT 75

  Fly   110 HFHRNSMASASLFLAAKVEEQPRKLEHVIRAANKCLPP------TTEQNYAELAQELVFNENVLL 168
            .|::|.::|.:||||||||||.|||||||:.|:.||.|      |....|.:..||||..|.::|
Human    76 KFNKNIISSTALFLAAKVEEQARKLEHVIKVAHACLHPLEPLLDTKCDAYLQQTQELVILETIML 140

  Fly   169 QTLGFDVAIDHPHTHVVRTCQLVKACKDLAQTSYFLASNSLHLTSMCLQYRPTVVACFCIYLACK 233
            |||||::.|:||||.||:..|||:|.|||||||||:|:||||||:.||||:|||:||.||:||||
Human   141 QTLGFEITIEHPHTDVVKCTQLVRASKDLAQTSYFMATNSLHLTTFCLQYKPTVIACVCIHLACK 205

  Fly   234 WSRWEIPQSTEGKHWFYYVDKTVSLDLLKQLTDEFIAIYEKSPARLKSKLNSIKAIAQGASNRTA 298
            ||.||||.||:||||:.|||.||:|:||.:||.||:.|.||:|.||| |:.:.:|      |:.|
Human   206 WSNWEIPVSTDGKHWWEYVDPTVTLELLDELTHEFLQILEKTPNRLK-KIRNWRA------NQAA 263

  Fly   299 NSKDKPKEDWKITEMMKGYHSNITTPPELLNGNDSRDRDRDRERERERERDPSSLLPPPAMVPQQ 363
            .   |||.|.:::|          ||  ||.                     |||:....:|
Human   264 R---KPKVDGQVSE----------TP--LLG---------------------SSLVQNSILV--- 289

  Fly   364 RRQDGGHQRSSSVSGVPGSSSSSSSSSHKMPNYPGGMPPDAHTDHKSKQPGYNNRMPSSHQRSSS 428
                      .||:|||.:.|....|:..   :|..:|.
Human   290 ----------DSVTGVPTNPSFQKPSTSA---FPAPVPL-------------------------- 315

  Fly   429 SGLGSSGSGSQRSSSSSSSSSQQPGRPSMPVDYHKSSRGMPPVGVGMPPHGSHKMTSGSKPQQPQ 493
                :||:.|.:.|.:|.:.|.             .:.|||....|:..|          .:.||
Human   316 ----NSGNISVQDSHTSDNLSM-------------LATGMPSTSYGLSSH----------QEWPQ 353

  Fly   494 QQPVPHPSASNSSASGMSSKDKSQSNKMYPNAPPPYSNSAPQNPLMSRGGYPGASNGSQPPPPAG 558
            .|                  |.:::.::|                            ||
Human   354 HQ------------------DSARTEQLY----------------------------SQ------ 366

  Fly   559 YGGHRSKSGSTVHGMPPFEQQLPYSQSQSYGHMQQQPVPQSQQQQMPPEASQHSLQSKNSLFSPE 623
                              :|:...|.||...:.||           .|..|.||
Human   367 ------------------KQETSLSGSQYNINFQQ-----------GPSISLHS----------- 391

  Fly   624 WPDIKKEPMSQSQPQPFNGLLPPPAPPGHDYKLNSHPRDKESPKKERLTPTKKDKHRPVMPPVGS 688
                              ||...|.      |::.|     |..|:..|      |:
Human   392 ------------------GLHHRPD------KISDH-----SSVKQEYT------HK-------- 413

  Fly   689 GNSSSGSGSSKPMLPPHKKQIPHGGDLLTNPGESGSLKRPNEISGSQYGLNKLDEIDNSNMPREK 753
                  :||||           |.|.:.|.||..     |.::|..:|              |||
Human   414 ------AGSSK-----------HHGPISTTPGII-----PQKMSLDKY--------------REK 442

  Fly   754 LRKLDTTTGLPTYPNY-----EEKHTPLNMSNGIETTPDLVRSLLKESLCPSNASLLKPDALTMP 813
             |||: |..|....:|     |::|     ..|             :|...|::|:..|..:.:|
Human   443 -RKLE-TLDLDVRDHYIAAQVEQQH-----KQG-------------QSQAASSSSVTSPIKMKIP 487

  Fly   814 GLKPPAELLEPMPAPATIKKEQGITPMTSLAS-GPAPMDLEVPTKQAGEIKEESSSKSEKKKKKD 877
            .......:.:......::|....|.|....|| ....|.::|.:.:.....:|.|.||:......
Human   488 IANTEKYMADKKEKSGSLKLRIPIPPTDKSASKEELKMKIKVSSSERHSSSDEGSGKSKHSSPHI 552

  Fly   878 KHKHKEKDKSKDKTEKEERKKHKKDKQKDRSGSGGSKDSSLPNEPLKMVIKNPNGSLQAGASAPI 942
            ...||||.| :..:.:.....||.......|.|||||.|:
Human   553 SRDHKEKHK-EHPSSRHHTSSHKHSHSHSGSSSGGSKHSA------------------------- 591

  Fly   943 KLKISKNKVEPNNYSAAAGLPGAIGYGLPPTTATTTSASIGAAAPVLPPYGAGGGGYSSSGGSSS 1007
                                     .|:|||.         ..:||         |.||.|.|||
Human   592 -------------------------DGIPPTV---------LRSPV---------GLSSDGISSS 613

  Fly  1008 GGSSKKK-H----SDRDRDKESKKNK--------SQDYAKYNGAGGGIFN-PL 1046
            ..||:|: |    |.....|.||.:|        |....:|..:...:|| ||
Human   614 SSSSRKRLHVNDASHNHHSKMSKSSKSSGSSSSSSSSVKQYISSHNSVFNHPL 666

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CycT	NP_524127.2	CYCLIN_CCNT_rpt1	45..174	CDD:410241	82/134 (61%)
		CYCLIN_CCNT_rpt2	179..268	CDD:410242	63/88 (72%)
CCNT2	NP_490595.1	Interaction with MDFIC and MDFI. /evidence=ECO:0000269|PubMed:17289077	1..300		178/344 (52%)
		CYCLIN_CCNT2_rpt1	8..146	CDD:410299	82/134 (61%)
		CYCLIN_CCNT2_rpt2	150..263	CDD:410301	75/119 (63%)
		Interaction with POLR2A. /evidence=ECO:0000269|PubMed:15563843	250..300		25/105 (24%)
		ROM1	296..>427	CDD:227709	49/338 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	341..430		37/250 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	497..652		48/223 (22%)