Protein Alignment CycT and CCNT1

DIOPT Version :10

• Sequence 1: NP_524127.2
• Gene: CycT / 39961
• FlyBaseID: FBgn0025455
• Length: 1097
• Species: Drosophila melanogaster
• Sequence 2: NP_001231.2
• Gene: CCNT1 / 904
• HGNCID: 1599
• Length: 726
• Species: Homo sapiens
• Alignment Length: 881
• Identity: 282/881 - (32%)
• Similarity: 384/881 - (43%)
• Gaps: 250/881 - (28%)

  Fly    34 NNNLPFEKDKIWYFSNDQLANSPSRRCGIKGDDELQYRQMTAYLIQEMGQRLQVSQLCINTAIVY 98
            |||      |.|||:.:||.||||||.|:..|.||.|||..|.|:|:|||||.||||.|||||||
Human     7 NNN------KRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVY 65

  Fly    99 MHRFYAFHSFTHFHRNSMASASLFLAAKVEEQPRKLEHVIRAANKC------LPPTTEQNYAELA 157
            |||||...|||.|..||:|.|:|||||||||||:||||||:.|:.|      ||.|..:.|.:..
Human    66 MHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQV 130

  Fly   158 QELVFNENVLLQTLGFDVAIDHPHTHVVRTCQLVKACKDLAQTSYFLASNSLHLTSMCLQYRPTV 222
            |:||..|:::||||||::.|||||||||:..|||:|.|||||||||:|:||||||:..|||.|.|
Human   131 QDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPV 195

  Fly   223 VACFCIYLACKWSRWEIPQSTEGKHWFYYVDKTVSLDLLKQLTDEFIAIYEKSPARLKSKLNSIK 287
            |||.||:||||||.||||.||:||||:.|||.||:|:||.:||.||:.|.||:|.|||...|
Human   196 VACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWN--- 257

  Fly   288 AIAQGASNRTANSKDKPKEDWKITEMMKGYHSNITTPPELLNGNDSRDRDRDRERERERERDPSS 352
                                |:..|..|...::              ||..|   |:..|:...:
Human   258 --------------------WRACEAAKKTKAD--------------DRGTD---EKTSEQTILN 285

  Fly   353 LLPPPAMVPQQRRQDGGHQRSSSVSGVPGSSSSSSSSSHKMPNYPGGMPPDAHTDHKSKQPGYNN 417
            ::                .:|||.:.:.|..|.|:|::..:|:.|
Human   286 MI----------------SQSSSDTTIAGLMSMSTSTTSAVPSLP-------------------- 314

  Fly   418 RMPSSHQRSSSSGLGSSGSGSQRSSSSSSSSSQQPGR------PSM---PVDYHKSSRGMPPVGV 473
                               .|:.|||:.:|....||:      ||.   |...|::|..:...||
Human   315 -------------------VSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGV 360

  Fly   474 --GMPPHGSHKMTSGSKPQQPQQQPVPHPSASNSSASGMSSKD----KSQSNKMYPNAPPPYSNS 532
              .:|..||:...|    |:...:.||....|........:::    |.|...|..|....|:.:
Human   361 DHSLPQDGSNAFIS----QKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYA 421

  Fly   533 APQNPLMSRGGY---------PGASNGSQP-------------PPPAGYGGHRSKSGS------- 568
            | ||.|.....:         .|:.|..:|             .|.|  ||.::.|..
Human   422 A-QNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVA--GGDKAASSKPEEIKMR 483

  Fly   569 -TVHGMPPFEQQLPYSQSQSYGHMQQQPVPQS-------------QQQQMP-------PEASQHS 612
             .||........:..|.::|..|.::.....|             ...|:|       |...:||
Human   484 IKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHS 548

  Fly   613 LQSKN---------SLFSPEWPDIKKEPMSQSQPQPFNGLLPPPAPPGHDYKLNSHP-RDKESPK 667
            .|:.|         |.||......|:.|..::....|:                 || :..:|.|
Human   549 SQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFD-----------------HPAKIAKSTK 596

  Fly   668 KERLTPTKKDKHRPVMPPVGS--GNSSSGSGSSKPMLPPHKKQIPHGGDLLTNPGESGSLKRPNE 730
            ...|     :...|.:|.:|.  |:||..||.|... |..|.::||.   ..:.|.:|:    |.
Human   597 SSSL-----NFSFPSLPTMGQMPGHSSDTSGLSFSQ-PSCKTRVPHS---KLDKGPTGA----NG 648

  Fly   731 ISGSQYGLNKLDEIDNSNMPREKLRKLDTTTGL-PTYPNYEEKHTP----LNMSNGIETTPDLVR 790
            .:.:|    .:|..|..||    |..|.:..|: ||.|...|...|    ||..:|
Human   649 HNTTQ----TIDYQDTVNM----LHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSG--------- 696

  Fly   791 SLLKESLCPSNASLLKPDALTMPGLKPPAELLEPMP 826
                 .:...:.:..||....:|...||.  |.|:|
Human   697 -----GISSRSGNTDKPRPPPLPSEPPPP--LPPLP 725

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CycT	NP_524127.2	CYCLIN_CCNT_rpt1	45..174	CDD:410241	82/134 (61%)
		CYCLIN_CCNT_rpt2	179..268	CDD:410242	63/88 (72%)
CCNT1	NP_001231.2	CYCLIN_CCNT1_rpt1	10..147	CDD:410298	83/136 (61%)
		CYCLIN_CCNT1_rpt2	151..259	CDD:410300	74/130 (57%)
		Nuclear localization signal, and interaction with Tat-TAR RNA. /evidence=ECO:0000305|PubMed:9491887	253..270		5/39 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	360..385		8/28 (29%)
		Histidine-rich domain (HRD). /evidence=ECO:0000269|PubMed:29849146, ECO:0000269|PubMed:35393539	480..550		11/69 (16%)
		Disordered. /evidence=ECO:0000269|PubMed:29849146	487..650		39/192 (20%)
		Required for interaction with ZMYND8. /evidence=ECO:0000269|PubMed:30134174	527..570		10/42 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	688..726		11/54 (20%)