DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CycT and CCNT1

DIOPT Version :9

Sequence 1:	NP_001261992.1	Gene:	CycT / 39961	FlyBaseID:	FBgn0025455	Length:	1097	Species:	Drosophila melanogaster
Sequence 2:	NP_001231.2	Gene:	CCNT1 / 904	HGNCID:	1599	Length:	726	Species:	Homo sapiens

Alignment Length:	881	Identity:	282/881 - (32%)
Similarity:	384/881 - (43%)	Gaps:	250/881 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 NNNLPFEKDKIWYFSNDQLANSPSRRCGIKGDDELQYRQMTAYLIQEMGQRLQVSQLCINTAIVY 98
            |||      |.|||:.:||.||||||.|:..|.||.|||..|.|:|:|||||.||||.|||||||
Human     7 NNN------KRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVY 65

  Fly    99 MHRFYAFHSFTHFHRNSMASASLFLAAKVEEQPRKLEHVIRAANKC------LPPTTEQNYAELA 157
            |||||...|||.|..||:|.|:|||||||||||:||||||:.|:.|      ||.|..:.|.:..
Human    66 MHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQV 130

  Fly   158 QELVFNENVLLQTLGFDVAIDHPHTHVVRTCQLVKACKDLAQTSYFLASNSLHLTSMCLQYRPTV 222
            |:||..|:::||||||::.|||||||||:..|||:|.|||||||||:|:||||||:..|||.|.|
Human   131 QDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPV 195

  Fly   223 VACFCIYLACKWSRWEIPQSTEGKHWFYYVDKTVSLDLLKQLTDEFIAIYEKSPARLKSKLNSIK 287
            |||.||:||||||.||||.||:||||:.|||.||:|:||.:||.||:.|.||:|.|||...|
Human   196 VACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWN--- 257

  Fly   288 AIAQGASNRTANSKDKPKEDWKITEMMKGYHSNITTPPELLNGNDSRDRDRDRERERERERDPSS 352
                                |:..|..|...::              ||..|   |:..|:...:
Human   258 --------------------WRACEAAKKTKAD--------------DRGTD---EKTSEQTILN 285

  Fly   353 LLPPPAMVPQQRRQDGGHQRSSSVSGVPGSSSSSSSSSHKMPNYPGGMPPDAHTDHKSKQPGYNN 417
            ::                .:|||.:.:.|..|.|:|::..:|:.|
Human   286 MI----------------SQSSSDTTIAGLMSMSTSTTSAVPSLP-------------------- 314

  Fly   418 RMPSSHQRSSSSGLGSSGSGSQRSSSSSSSSSQQPGR------PSM---PVDYHKSSRGMPPVGV 473
                               .|:.|||:.:|....||:      ||.   |...|::|..:...||
Human   315 -------------------VSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGV 360

  Fly   474 --GMPPHGSHKMTSGSKPQQPQQQPVPHPSASNSSASGMSSKD----KSQSNKMYPNAPPPYSNS 532
              .:|..||:...|    |:...:.||....|........:::    |.|...|..|....|:.:
Human   361 DHSLPQDGSNAFIS----QKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYA 421

  Fly   533 APQNPLMSRGGY---------PGASNGSQP-------------PPPAGYGGHRSKSGS------- 568
            | ||.|.....:         .|:.|..:|             .|.|  ||.::.|..
Human   422 A-QNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVA--GGDKAASSKPEEIKMR 483

  Fly   569 -TVHGMPPFEQQLPYSQSQSYGHMQQQPVPQS-------------QQQQMP-------PEASQHS 612
             .||........:..|.::|..|.::.....|             ...|:|       |...:||
Human   484 IKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHS 548

  Fly   613 LQSKN---------SLFSPEWPDIKKEPMSQSQPQPFNGLLPPPAPPGHDYKLNSHP-RDKESPK 667
            .|:.|         |.||......|:.|..::....|:                 || :..:|.|
Human   549 SQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFD-----------------HPAKIAKSTK 596

  Fly   668 KERLTPTKKDKHRPVMPPVGS--GNSSSGSGSSKPMLPPHKKQIPHGGDLLTNPGESGSLKRPNE 730
            ...|     :...|.:|.:|.  |:||..||.|... |..|.::||.   ..:.|.:|:    |.
Human   597 SSSL-----NFSFPSLPTMGQMPGHSSDTSGLSFSQ-PSCKTRVPHS---KLDKGPTGA----NG 648

  Fly   731 ISGSQYGLNKLDEIDNSNMPREKLRKLDTTTGL-PTYPNYEEKHTP----LNMSNGIETTPDLVR 790
            .:.:|    .:|..|..||    |..|.:..|: ||.|...|...|    ||..:|
Human   649 HNTTQ----TIDYQDTVNM----LHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSG--------- 696

  Fly   791 SLLKESLCPSNASLLKPDALTMPGLKPPAELLEPMP 826
                 .:...:.:..||....:|...||.  |.|:|
Human   697 -----GISSRSGNTDKPRPPPLPSEPPPP--LPPLP 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycT	NP_001261992.1	Cyclin_N	42..176	CDD:278560	84/139 (60%)
CycT	NP_001261992.1	CYCLIN	<203..>251	CDD:214641	34/47 (72%)
CCNT1	NP_001231.2	Cyclin_N	13..149	CDD:278560	82/135 (61%)
		Nuclear localization signal, and interaction with Tat-TAR RNA. /evidence=ECO:0000255	253..270		5/39 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	360..385		8/28 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	487..650		39/192 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	688..726		11/54 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149866
Domainoid	1	1.000	168	1.000	Domainoid score	I3835
eggNOG	1	0.900	-	-		E1_COG5333
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	329	1.000	Inparanoid score	I2459
Isobase	1	0.950	-	0	Normalized mean entropy	S4587
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1437076at2759
OrthoFinder	1	1.000	-	-		FOG0002290
OrthoInspector	1	1.000	-	-		otm40890
orthoMCL	1	0.900	-	-		OOG6_105617
Panther	1	1.100	-	-	LDO	PTHR10026
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2329
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.710