Protein Alignment CycT and CCNK

DIOPT Version :10

• Sequence 1: NP_524127.2
• Gene: CycT / 39961
• FlyBaseID: FBgn0025455
• Length: 1097
• Species: Drosophila melanogaster
• Sequence 2: NP_001092872.1
• Gene: CCNK / 8812
• HGNCID: 1596
• Length: 580
• Species: Homo sapiens
• Alignment Length: 725
• Identity: 176/725 - (24%)
• Similarity: 270/725 - (37%)
• Gaps: 209/725 - (28%)

  Fly    30 PITANNNLPFEKDKIWYFSNDQLANSPSRRCGIKGDDELQYRQMTAYLIQEMGQRLQVSQLCINT 94
            |...:.||...| ..||:....||::||:..|:....|.:||:..|..|.::|.||.:....:.|
Human    10 PSVTSANLDHTK-PCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLAT 73

  Fly    95 AIVYMHRFYAFHSFTHFHRNSMASASLFLAAKVEEQPRKLEHVIRAANKCLPPTTEQNYAELA-- 157
            .|:|.||||.||||..|.|....:..||||.||||.|:|.:.:|:.|...|   .:..:.:..
Human    74 GIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLL---NDVQFGQFGDD 135

  Fly   158 --QELVFNENVLLQTLGFDVAIDHPHTHVVRTCQLVKACKD----LAQTSYFLASNSLHLTSMCL 216
              :|::..|.:||||:.||:.::||:..:::..:.:|..|:    |.|.::...::|| .|::.|
Human   136 PKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSL-CTTLSL 199

  Fly   217 QYRPTVVACFCIYLACKWSRWEIPQSTEG---KHWFYYVDKTVSLDLLKQLTDEFIAIYEKSPAR 278
            |:.|.::|...:|||.:..::||.:.|..   :.|:....:.|.:|:|:.:..:.:.:|.:...:
Human   200 QWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQ 264

  Fly   279 LKSKLNSIKAIAQGASNRTANSKDKPKEDWKITEMMKGYHSNITTPPELLNGNDSRDRDRDRERE 343
            :.                                    :|    ||.:|
Human   265 MP------------------------------------HH----TPHQL---------------- 273

  Fly   344 RERERDPSSLLPPPAMVPQQRRQDGGHQRSSSVSGVPGSSSSSSSSSHKMPNYPGGMPPDAHTDH 408
                :.|.||.|.| .|||.::..            |..||..|....|.|..|      |....
Human   274 ----QQPPSLQPTP-QVPQVQQSQ------------PSQSSEPSQPQQKDPQQP------AQQQQ 315

  Fly   409 KSKQPGYNNRMPSSHQRSSSSGLGSSGSGSQRSSSSSSSSSQQPGRPSMP---------VDYHKS 464
            .::||...:..|||.::...:.:         .|....:.:.:|..|.:|         ...|..
Human   316 PAQQPKKPSPQPSSPRQVKRAVV---------VSPKEENKAAEPPPPKIPKIETTHPPLPPAHPP 371

  Fly   465 SRGMPPVGVGM---PPHGSHKMTSGSKPQQP---------QQQPVPH---PSASNSSASGMSSKD 514
            ....||:...:   .|.|....|...|.|.|         |..|:||   |...:|..:|||:..
Human   372 PDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTS 436

  Fly   515 KSQSNKMYPNAPPPYSNSAPQNPLMSRGGYPGASNGSQPPPPAGYGGHRSKSGSTVHGMPPFEQQ 579
            ...|.:.|.:             |.|.....|.|.|:.||   .||             ||  ..
Human   437 SYMSGEGYQS-------------LQSMMKTEGPSYGALPP---AYG-------------PP--AH 470

  Fly   580 LPYSQSQSYGHMQQQPVPQSQQQQMPPEASQHSLQSKNSLFSPEWPDIKKEPMSQSQPQP---FN 641
            |||.......:....|||       ||.||          |.|  |.|  .|.:...|.|   :|
Human   471 LPYHPHVYPPNPPPPPVP-------PPPAS----------FPP--PAI--PPPTPGYPPPPPTYN 514

  Fly   642 GLLPPP---APPGHDYKLNSHPRDKESPKKERLTPTKKDKHRPVMPPVGSGNSSSGSGSSKPMLP 703
            ...|||   .||.|  .:..||     |....|.|.....  |.:||          |...|:.|
Human   515 PNFPPPPPRLPPTH--AVPPHP-----PPGLGLPPASYPP--PAVPP----------GGQPPVPP 560

  Fly   704 PHKKQIPHGG 713
            |    ||..|
Human   561 P----IPPPG 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CycT	NP_524127.2	CYCLIN_CCNT_rpt1	45..174	CDD:410241	47/132 (36%)
		CYCLIN_CCNT_rpt2	179..268	CDD:410242	23/95 (24%)
CCNK	NP_001092872.1	CYCLIN_CCNK_rpt1	40..154	CDD:410233	41/116 (35%)
		CYCLIN_CCNK_rpt2	158..258	CDD:410234	23/100 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	262..580		99/468 (21%)