Protein Alignment CycT and CCNL2

DIOPT Version :10

• Sequence 1: NP_524127.2
• Gene: CycT / 39961
• FlyBaseID: FBgn0025455
• Length: 1097
• Species: Drosophila melanogaster
• Sequence 2: XP_011540518.1
• Gene: CCNL2 / 81669
• HGNCID: 20570
• Length: 553
• Species: Homo sapiens
• Alignment Length: 600
• Identity: 145/600 - (24%)
• Similarity: 237/600 - (39%)
• Gaps: 161/600 - (26%)

  Fly    11 AATASSSSSASAAASA----------------------SGIPITANNNLPFEKDKIWYFSNDQLA 53
            ||.|.::.||:.||:|                      ||:.||..|.|         ..:|:|.
Human     5 AAAAGAAGSAAPAAAAGAPGSGGAPSGSQGVLIGDRLYSGVLITLENCL---------LPDDKLR 60

  Fly    54 NSPSRRCGIKGDDELQYRQMTAYLIQEMGQRLQVSQLCINTAIVYMHRFYAFHSFTHFHRNSMAS 118
            .:||...|:..|.|...|.:...|||..|..|::.|:.:.|..|...||:...||.   ::||..
Human    61 FTPSMSSGLDTDTETDLRVVGCELIQAAGILLRLPQVAMATGQVLFQRFFYTKSFV---KHSMEP 122

  Fly   119 ASLF------------------LAAKVEE------QPRKLEHVIRAANKCL-PPTT--------- 149
            :||:                  .:|.|..      |.|:........::|: ||:|
Human   123 SSLWRPSGRRGWGQTWACCNASASACVNGLCPPGFQDRRGPKTHTGRHQCVSPPSTAERQKTLCS 187

  Fly   150 -----------EQNYAELAQELVFNENVLLQTLGFDVAIDHPHTHVVRTCQLVKACKD--LAQTS 201
                       :|:|..|..:::..|..:|:.|||.|.:.|||..:|...|:::..::  |.|||
Human   188 LSGRKPVPLLLDQDYVNLKNQIIKAERRVLKELGFCVHVKHPHKIIVMYLQVLECERNQHLVQTS 252

  Fly   202 YFLASNSLHLTSMCLQYRPTVVACFCIYLACKWSRWEIPQSTEGKHWFYYVDKTVSLDLLKQLTD 266
            :...::||. |.:.::::|..:||.|||||.:  ..|||.... .|||.....|.  :.::::..
Human   253 WNYMNDSLR-TDVFVRFQPESIACACIYLAAR--TLEIPLPNR-PHWFLLFGATE--EEIQEICL 311

  Fly   267 EFIAIYEKSPARLKSKLNSIKAIAQGASNRTANSKDKPKEDWK-----ITEMMKGYHSNITTPPE 326
            :.:.:|    ||.|..|..:    :|...:..::.::.|...:     .|:::.| .|..:..|:
Human   312 KILQLY----ARKKVDLTHL----EGEVEKRKHAIEEAKAQARGLLPGGTQVLDG-TSGFSPAPK 367

  Fly   327 LLNGNDSRDRDRDRERERERERDPSSLLPPPAMVPQQRRQDGGHQRS---SSVSGVPGSSSSSSS 388
            |:                |..::.....|.|..|...:|:..|.:::   |.|:|:|....|.|.
Human   368 LV----------------ESPKEGKGSKPSPLSVKNTKRRLEGAKKAKADSPVNGLPKGRESRSR 416

  Fly   389 SSHKMPNYPGGMPPDAHTDHKSKQPGYNNRMPSSHQRSSSSGLGSSGSGSQRSSSSSSSSSQQPG 453
            |..:..:|             |:.|   :|..|..:|.|.||..|.||.||..|.|.|.|..:..
Human   417 SRSREQSY-------------SRSP---SRSASPKRRKSDSGSTSGGSKSQSRSRSRSDSPPRQA 465

  Fly   454 RPSMPVDYHKSSRGMPPVGVGMPPHGSHKMTSGSKPQQPQQQPVPHPSASNSSASGMSSKDKSQS 518
            ..|.|..             |....||.|......||:      ||.|.|.|     ||:.:|:|
Human   466 PRSAPYK-------------GSEIRGSRKSKDCKYPQK------PHKSRSRS-----SSRSRSRS 506

  Fly   519 NKMYPNAPPPYSNSA 533
            .:...| |..|...:
Human   507 RERADN-PGKYKKKS 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CycT	NP_524127.2	CYCLIN_CCNT_rpt1	45..174	CDD:410241	39/173 (23%)
		CYCLIN_CCNT_rpt2	179..268	CDD:410242	27/90 (30%)
CCNL2	XP_011540518.1	CYCLIN_SF	35..223	CDD:477360	45/199 (23%)
		CYCLIN_CCNL2_rpt2	228..350	CDD:410296	34/135 (25%)