DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CycT and ccnt2a

DIOPT Version :9

Sequence 1:	NP_001261992.1	Gene:	CycT / 39961	FlyBaseID:	FBgn0025455	Length:	1097	Species:	Drosophila melanogaster
Sequence 2:	NP_001180310.1	Gene:	ccnt2a / 327568	ZFINID:	ZDB-GENE-030131-5779	Length:	693	Species:	Danio rerio

Alignment Length:	726	Identity:	243/726 - (33%)
Similarity:	325/726 - (44%)	Gaps:	197/726 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 WYFSNDQLANSPSRRCGIKGDDELQYRQMTAYLIQEMGQRLQVSQLCINTAIVYMHRFYAFHSFT 109
            |:|:.:||..:||||||::.|.||.|||..|.|||:|||||.||||.||||||||||||.:||||
Zfish    11 WFFTREQLETTPSRRCGVEPDRELSYRQQAANLIQDMGQRLNVSQLTINTAIVYMHRFYMYHSFT 75

  Fly   110 HFHRNSMASASLFLAAKVEEQPRKLEHVIRAANKCLPP------TTEQNYAELAQELVFNENVLL 168
            .||||.::..:||||||||||||||||||:.|:.||.|      |....|.:.|||||..|.::|
Zfish    76 KFHRNIISPTTLFLAAKVEEQPRKLEHVIKVAHACLNPQEPPLDTKSNAYLQQAQELVILETIVL 140

  Fly   169 QTLGFDVAIDHPHTHVVRTCQLVKACKDLAQTSYFLASNSLHLTSMCLQYRPTVVACFCIYLACK 233
            |||||::.|:||||.||:..|||:|.|||||||||:|:||||||:.|||::|||:||.||:||||
Zfish   141 QTLGFEITIEHPHTDVVKCSQLVRASKDLAQTSYFMATNSLHLTTFCLQHKPTVIACVCIHLACK 205

  Fly   234 WSRWEIPQSTEGKHWFYYVDKTVSLDLLKQLTDEFIAIYEKSPARLKSKLNSIKAIAQGASNRTA 298
            ||.||||.||:||||:.|||.:|:|:||.:||.||:.|.||:|:|||...|.          |..
Zfish   206 WSNWEIPVSTDGKHWWEYVDNSVTLELLDELTHEFLQILEKTPSRLKRIRNW----------RAT 260

  Fly   299 NSKDKPKEDWKITEMMKGYHSNITTPPELLNGNDSRDRDRDRERERERERDPSSLLPPPAMVPQQ 363
            .:..|||.|.:.::......|::|                         :|||.:...|.:....
Zfish   261 QAAKKPKSDNQGSDSSSLAGSSLT-------------------------QDPSLMDTLPGVSTST 300

  Fly   364 RRQDGGHQRSSSVSGVPGSSSSSSSSSHKMPNYPG-----GMPPDAHTDHKSKQPGYNNRMPSSH 423
            ....|.......:||    :||||.|...:.|..|     ..|.|...|.....| |:.:...||
Zfish   301 AFSKGSTSFPVCLSG----NSSSSLSLDSIANMQGTSYTYTAPSDWPQDQLRSDP-YSVKQLPSH 360

  Fly   424 QRSSSSGLGSSGSGSQRSSSSSSSSSQQPGRPSMPVDY------HKSSRGMPPVGVGMPPHG--S 480
                                    ||..|.||....|.      ||.|.|........|||.  :
Zfish   361 ------------------------SSMHPQRPDKSADLNPTKHEHKVSGGTKHQATTYPPHAAPT 401

  Fly   481 HKMT----------------------------SGSKPQQPQQQPVPHPS-----ASNSSASGMSS 512
            .||:                            .|:..|...::.:||.|     |..::||.:..
Zfish   402 QKMSLDKYREKHAAELAVQKRKQEQQNVETEVYGATTQTDHRKHLPHLSHGQQGAGVTTASPLKI 466

  Fly   513 K-----------DKSQSNKMYPNAPPPYSNSAPQNPLMSRGGYPGASN---------GSQPPPPA 557
            |           :|..|.|:             :.|:.|:....|:|.         .|:....:
Zfish   467 KLPGQDKIQDKCEKGSSLKL-------------RLPVPSQSEKGGSSKEELKMKIKVSSERHSSS 518

  Fly   558 GYGGHRSKSGSTVHGMPPFEQQLPYSQSQSYGHMQQQPVPQSQQQQMPPEASQHSLQSKNSLFSP 622
            ..|..:||..|.:...........:.....:||               .....||...::||..|
Zfish   519 DEGAAKSKHSSPLVSKEKHRDHSAHRHHHKHGH---------------SHTHTHSGNGRSSLEVP 568

  Fly   623 EWPDIKKEPMSQSQPQPFNGLLPPPAPPGHDYKLNSHPRDKESPKKERLTPTKKDKHRPVMPPVG 687
            ....:...|.|.|                      |..|.:.:|:......:||:|
Zfish   569 TTGSVADGPSSAS----------------------SSSRKRVNPEASHNHHSKKNK--------- 602

  Fly   688 SGNSSSGSGSS 698
              :|.||:|||
Zfish   603 --SSKSGAGSS 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycT	NP_001261992.1	Cyclin_N	42..176	CDD:278560	85/136 (63%)
CycT	NP_001261992.1	CYCLIN	<203..>251	CDD:214641	34/47 (72%)
ccnt2a	NP_001180310.1	Cyclin_N	12..148	CDD:278560	84/135 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584013
Domainoid	1	1.000	201	1.000	Domainoid score	I2962
eggNOG	1	0.900	-	-		E1_COG5333
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	370	1.000	Inparanoid score	I2085
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1437076at2759
OrthoFinder	1	1.000	-	-		FOG0002290
OrthoInspector	1	1.000	-	-		otm24653
orthoMCL	1	0.900	-	-		OOG6_105617
Panther	1	1.100	-	-	LDO	PTHR10026
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4505
SonicParanoid	1	1.000	-	-		X2329
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.790