DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CycT and ccnt2b

DIOPT Version :9

Sequence 1:	NP_001261992.1	Gene:	CycT / 39961	FlyBaseID:	FBgn0025455	Length:	1097	Species:	Drosophila melanogaster
Sequence 2:	NP_997751.1	Gene:	ccnt2b / 321464	ZFINID:	ZDB-GENE-030131-183	Length:	569	Species:	Danio rerio

Alignment Length:	585	Identity:	220/585 - (37%)
Similarity:	292/585 - (49%)	Gaps:	134/585 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 WYFSNDQLANSPSRRCGIKGDDELQYRQMTAYLIQEMGQRLQVSQLCINTAIVYMHRFYAFHSFT 109
            |.|:.:|..|:||||||::.|.||.|||..|.|||:|||||.||||.||||||||||||..:|||
Zfish    12 WLFTREQFENTPSRRCGVEPDRELSYRQQAANLIQDMGQRLNVSQLTINTAIVYMHRFYMLNSFT 76

  Fly   110 HFHRNSMASASLFLAAKVEEQPRKLEHVIRAANKCL----PPTTEQN--YAELAQELVFNENVLL 168
            .||||.::..:||||||||||||||||||:.|:.||    ||...::  |.:.|||||..|.::|
Zfish    77 KFHRNIISPTTLFLAAKVEEQPRKLEHVIKVAHACLNPHDPPLDSKSSAYLQQAQELVLLETIVL 141

  Fly   169 QTLGFDVAIDHPHTHVVRTCQLVKACKDLAQTSYFLASNSLHLTSMCLQYRPTVVACFCIYLACK 233
            |||||::.|:||||.|||..|||:|.|||||||||:|:||||||:.|||::||||||.||:||||
Zfish   142 QTLGFEITIEHPHTDVVRCTQLVRASKDLAQTSYFMATNSLHLTTFCLQHKPTVVACVCIHLACK 206

  Fly   234 WSRWEIPQSTEGKHWFYYVDKTVSLDLLKQLTDEFIAIYEKSPARLKSKLN-------------- 284
            ||.||||.|::||||:.|||:.|:|.||..||.||:.|.||:|:|||...|
Zfish   207 WSNWEIPVSSDGKHWWEYVDRAVTLQLLDDLTHEFLQILEKTPSRLKRIRNWRATQAAKKPKLDN 271

  Fly   285 -----SIKAIAQ---------------------------------GASNRTANSKDKPKEDWKIT 311
                 |.:::.|                                 |.||..:::...|....:..
Zfish   272 QSLDGSFQSLNQDTSLMSSMCDLGAGMYSDPSTSFPLDGSSLSLNGLSNLQSSAFGFPAPISQTA 336

  Fly   312 EMM---------KGYHSNITTPPELLNGNDSRDRDRDRERERERERDPSSLLPPPAMVPQQRRQD 367
            :..         |..||:.|..|:.|.....|::..:.|:.|..|                 .:|
Zfish   337 DAFLALQAAPTSKHGHSSATLAPQKLTLEKYREKQTELEQRRRHE-----------------EED 384

  Fly   368 GG-HQRSSSVSGVPGSSSSSSSSSHKMPNYPGGMPPDAHTDHKSKQPGYNNRMPSSHQRSSSS-- 429
            |. |::...::..|.:|.....:..::...|            ||......|.|||.:..|:|
Zfish   385 GDQHRKHGHLTSEPSTSIRLKYNQQQVLERP------------SKSGSLKRRHPSSSENGSASQE 437

  Fly   430 ------GLGSSGSGSQRSSSSSSSSSQQPGRPSMPVDYHKSSRGMPPVGVGMPPHGSHKMTSGSK 488
                  .:.|..|||.:|..|..||.::....|.    ||::|     ......||||..
Zfish   438 ELKMKIKVSSDSSGSSKSRHSPLSSREKHREHSS----HKTAR-----HDSSHSHGSHHH----- 488

  Fly   489 PQQPQQQPVPHPSASNSSASGMSSKDKSQSNKMYPNAPPPYSNSAPQNPLMSRGGYPGASNGSQP 553
                     .|....:||.|..|||..|.|..:..|    .:...||...:.|  ..|..:||:|
Zfish   489 ---------HHHHHHHSSKSHRSSKSHSSSASISVN----QAIGQPQLAKIDR--RMGEGHGSEP 538

Fly 554 553
Zfish 539 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycT	NP_001261992.1	Cyclin_N	42..176	CDD:278560	84/136 (62%)
CycT	NP_001261992.1	CYCLIN	<203..>251	CDD:214641	34/47 (72%)
ccnt2b	NP_997751.1	Cyclin_N	13..149	CDD:278560	83/135 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584012
Domainoid	1	1.000	201	1.000	Domainoid score	I2962
eggNOG	1	0.900	-	-		E1_COG5333
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	370	1.000	Inparanoid score	I2085
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1437076at2759
OrthoFinder	1	1.000	-	-		FOG0002290
OrthoInspector	1	1.000	-	-		otm24653
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10026
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2329
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.860