DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CycT and Ccnt2

DIOPT Version :9

Sequence 1:	NP_001261992.1	Gene:	CycT / 39961	FlyBaseID:	FBgn0025455	Length:	1097	Species:	Drosophila melanogaster
Sequence 2:	NP_001100641.1	Gene:	Ccnt2 / 304758	RGDID:	1309205	Length:	722	Species:	Rattus norvegicus

Alignment Length:	812	Identity:	274/812 - (33%)
Similarity:	382/812 - (47%)	Gaps:	170/812 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 WYFSNDQLANSPSRRCGIKGDDELQYRQMTAYLIQEMGQRLQVSQLCINTAIVYMHRFYAFHSFT 109
            |:|:.:||.|:||||||::.|:||.:||..|.|||:|||||.||||.||||||||||||..||||
  Rat    11 WFFTREQLENTPSRRCGVEADEELSHRQQAANLIQDMGQRLNVSQLTINTAIVYMHRFYMHHSFT 75

  Fly   110 HFHRNSMASASLFLAAKVEEQPRKLEHVIRAANKCLPP------TTEQNYAELAQELVFNENVLL 168
            .|:||.::..:||||||||||.|||||||:.|:.||.|      |....|.:..||||..|.::|
  Rat    76 KFNRNIISPTALFLAAKVEEQARKLEHVIKVAHACLHPLEPLLDTKCDAYLQQTQELVLLETIML 140

  Fly   169 QTLGFDVAIDHPHTHVVRTCQLVKACKDLAQTSYFLASNSLHLTSMCLQYRPTVVACFCIYLACK 233
            |||||::.|:||||.||:..|||:|.|||||||||:|:||||||:.||||:|||:||.||:||||
  Rat   141 QTLGFEITIEHPHTDVVKCTQLVRASKDLAQTSYFMATNSLHLTTFCLQYKPTVIACVCIHLACK 205

  Fly   234 WSRWEIPQSTEGKHWFYYVDKTVSLDLLKQLTDEFIAIYEKSPARLKSKLNSIKAIAQGASNRTA 298
            ||.||||.||:||||:.|||.||:|:||.:||.||:.|.||:|:||| ::.:.:|:|:
  Rat   206 WSNWEIPVSTDGKHWWEYVDPTVTLELLDELTHEFLQILEKTPSRLK-RIRNWRAMAK------- 262

  Fly   299 NSKDKPKEDWKITEMMKGYHSNITTP---PELLNGNDSRDRDRDRERERERERDPSSLLPPP--- 357
                |||.|.:::|          ||   ..|:..:...|...........::..:|..|.|
  Rat   263 ----KPKVDGQVSE----------TPLLGSSLVQNSILVDSVTGVPANPSFQKPSTSTFPAPLPL 313

  Fly   358 ----AMVPQQRRQDGGHQRSSSVSGVPGSSSSSSSSSHKMPNYPGGMPPDAHTDHKSKQPGYNNR 418
                ..|...|..|.|    |.::|:| |||.:.||..:.|::    |..|.||     |.|..:
  Rat   314 TSGSTSVQDGRASDTG----SVLAGMP-SSSYTVSSHQEWPHH----PDSARTD-----PVYTQK 364

  Fly   419 MPSSHQRSSSSGLGSSGSGSQ----RSSSSSSSSSQQPGRPSMPVDYHKSSRGMPPVGVGMPPHG 479
            ..::.            ||||    :...|.:..|....||....|:..:.:.....|.....||
  Rat   365 QEATL------------SGSQYLSFQQGPSMALHSGLHHRPDKVADHSSAKQEYTHKGGSSKHHG 417

  Fly   480 SHKMTSGSKPQQPQQQPVPHPSASNSSASGMSSKDKSQSNKMYPNAPPPYSNSAPQNPLMSRGGY 544
            ....|.|..||:                   .|.||.:..:.....           .|.||..|
  Rat   418 PIPATPGVVPQK-------------------MSLDKYREKRKLETL-----------DLDSRDHY 452

  Fly   545 PGASNGSQPPPPAGYGGHRSKSGSTVHGMPPFEQQLPYSQS-QSYGHMQQQ-----------PVP 597
            ..|....|..    :|..::.:|::|  ..|.:.:||.:.| :...|:.::           |:|
  Rat   453 MAAHAEQQHK----HGPAQAVAGTSV--TSPIKMKLPLTNSDKPEKHLAEKRERSGSLKLRIPIP 511

  Fly   598 QSQQQQMPPE--ASQHSLQSKNSLFSPEWPDIKKEPMSQSQPQPFNGLLPPPAPPGHDYKLNSHP 660
                   ||:  .|:..|:.|..:.|.|......|...:|:..      .|.....|..|...||
  Rat   512 -------PPDKGPSKEELKMKIKVSSSERHSSSDEGSGKSKHS------SPHISRDHKEKHKEHP 563

  Fly   661 --RDKESPKKERLTPTKKDKHRPVMP------PVGSGNSSSGSGSSKPMLPPHKKQIPHGGDLLT 717
              |...|.|...:..:...||...||      |||.|.....||      |..:|:: |..|...
  Rat   564 ANRHHSSHKHLHMHSSGGSKHADGMPPTVLRSPVGLGPEGISSG------PSARKKL-HINDASH 621

  Fly   718 NPGESGSLKRPNEISGS--------QYGLNKLDEIDNSNMP-------------REKLRKLDTTT 761
            |  ....:.:.::.|||        || |:....:.|..:|             ...|.|||...
  Rat   622 N--HHSKMSKSSKSSGSSSSSSSVKQY-LSSHSSVFNHPLPPPPPVTYQVGYGHLSTLVKLDKKP 683

  Fly   762 GLPTYPNYEEKHTPLNMSNGIETTPDLVRSLL 793
            ..|..|....:::..:.....:.|.|::.|||
  Rat   684 VEPHGPEANHEYSTSSQHMDYKDTFDMLDSLL 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycT	NP_001261992.1	Cyclin_N	42..176	CDD:278560	82/136 (60%)
CycT	NP_001261992.1	CYCLIN	<203..>251	CDD:214641	35/47 (74%)
Ccnt2	NP_001100641.1	CCL1	8..>216	CDD:227640	131/204 (64%)
Ccnt2	NP_001100641.1	CYCLIN	36..108	CDD:238003	51/71 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343760
Domainoid	1	1.000	180	1.000	Domainoid score	I3414
eggNOG	1	0.900	-	-		E1_COG5333
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	341	1.000	Inparanoid score	I2276
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1437076at2759
OrthoFinder	1	1.000	-	-		FOG0002290
OrthoInspector	1	1.000	-	-		oto96429
orthoMCL	1	0.900	-	-		OOG6_105617
Panther	1	1.100	-	-	LDO	PTHR10026
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2329
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760