Protein Alignment CycT and CycT

DIOPT Version :10

• Sequence 1: NP_524127.2
• Gene: CycT / 39961
• FlyBaseID: FBgn0025455
• Length: 1097
• Species: Drosophila melanogaster
• Sequence 2: XP_316716.4
• Gene: CycT / 1277267
• VectorBaseID: AGAMI1_004995
• Length: 1499
• Species: Anopheles gambiae
• Alignment Length: 1469
• Identity: 493/1469 - (33%)
• Similarity: 634/1469 - (43%)
• Gaps: 496/1469 - (33%)

  Fly    20 ASAAASASGIPITANNNLPFEKDKIWYFSNDQLANSPSRRCGIKGDDELQYRQMTAYLIQEMGQR 84
            ||.:.||||  .|:.|:     |..|||:.:||||||||:.|:..|.||.|||..|.|||:||||
Mosquito     2 ASGSGSASG--TTSKND-----DSKWYFTAEQLANSPSRKAGMDADQELMYRQRAANLIQDMGQR 59

  Fly    85 LQVSQLCINTAIVYMHRFYAFHSFTHFHRNSMASASLFLAAKVEEQPRKLEHVIRAANKCL---- 145
            |||||||||||||||||||||||||.|||||:|:|:||||||||||||||||:|:..:..|
Mosquito    60 LQVSQLCINTAIVYMHRFYAFHSFTQFHRNSIAAAALFLAAKVEEQPRKLEHIIKVVHISLGMEA 124

  Fly   146 PPTTEQNYAELAQELVFNENVLLQTLGFDVAIDHPHTHVVRTCQLVKACKDLAQTSYFLASNSLH 210
            |....::|||.||:||||||||||||||||||||||||||:||.||||.|||||||||:||||||
Mosquito   125 PDPLRESYAEQAQDLVFNENVLLQTLGFDVAIDHPHTHVVKTCHLVKASKDLAQTSYFMASNSLH 189

  Fly   211 LTSMCLQYRPTVVACFCIYLACKWSRWEIPQSTEGKHWFYYVDKTVSLDLLKQLTDEFIAIYEKS 275
            ||:|||||:|||||||||:|||||||||||||.||:|||:||||||:|||||||||||:.|:::.
Mosquito   190 LTTMCLQYKPTVVACFCIHLACKWSRWEIPQSNEGRHWFHYVDKTVTLDLLKQLTDEFLHIFDRC 254

  Fly   276 PARLKSKLNSIKAI--AQGASNRTANSKDKPKEDWKITEMMKGYHSNITTP---PELLNGNDSRD 335
            |.|||||:.||:|.  |:.:..||..|...       :..:....|:.:.|   .|...|:.|..
Mosquito   255 PTRLKSKMKSIRADSGAEESGRRTGGSSSS-------SNSLMAAPSSSSVPRGLDEASTGSSSAS 312

  Fly   336 RDRDRERERERERDPSSLLPPPAMVPQQRRQDGGHQRSSSVSGVPGSSSSSSSSSHKMPNYPGGM 400
                 ...|.::...|.::.|..|     ...|.||:      :|.|||||:||..:     ...
Mosquito   313 -----SHHRPKQGSSSDMMKPHGM-----SSSGSHQK------IPSSSSSSASSRSR-----SDR 356

  Fly   401 PPDAHTDHKSKQPGYNNRMPSSHQRSSSSGLGSSGSGSQRSSSSSSSSSQQPG----RPSMPVDY 461
            ||.| :...:.||......||.|..|.||...||.:.|:...||...|.|||.    .||..|..
Mosquito   357 PPSA-SGTLAGQPQQQPPPPSQHYGSGSSSNSSSSTSSKGPMSSHRGSMQQPSSLQLNPSGAVPS 420

  Fly   462 HKSSRGMPPVGVGMPPHGSHKMTSGSKPQQPQ------QQP---VPHPSASNSSA-SGMSSKDKS 516
            .:|..|          :..|:  .|||.:||.      ||.   .|..||..|:| ||.||...|
Mosquito   421 QRSGSG----------YQGHE--GGSKSRQPSSASGLLQQASGGAPAGSAGGSTASSGSSSSMHS 473

  Fly   517 QSNKM-----------YPNAPPPYSNSAPQNPLMSRGGYPGASN---------GSQPPP------ 555
            ..|:|           .|:.||..|:|:     .|.|...|..|         .|||..
Mosquito   474 GYNQMKADRHGSSGQKLPSKPPSSSSSS-----SSSGAAVGGPNYGTKQHPAPSSQPSSSSLFSH 533

  Fly   556 PAGYGGHRSKSGSTVHGMPPFEQQLPYSQSQS--YGHMQQQPVPQ--------------SQQQQM 604
            |..|  ::|.||.|.: :|..:||...|.|.|  .|....||.|:              :...||
Mosquito   534 PPSY--NQSISGRTTN-VPLADQQSATSGSSSSNSGSSSNQPKPEPSTFRLLDESIGRLADPMQM 595

  Fly   605 --PPEASQHSLQSKNSLFSPEWPDIKKE-----PMSQSQPQ------------PFNGLLPPP--A 648
              ||:.|:.|     |:|||:|.|.:.|     |..:|:..            |.:.||.||  :
Mosquito   596 CTPPKQSKPS-----SIFSPDWKDSQTESLQNLPSGKSRSSGHYGNVASAGGAPADRLLKPPKGS 655

  Fly   649 PPGHDYKLNSHPRD------KESPKKER-----------LTPTKKDKHRPV-------------M 683
            |.|...:.......      .:..||:|           ..|....||:|:             :
Mosquito   656 PSGKKQQQQQQQHHGMAGSRSDGQKKDRRMDGSVGGLAGQQPPASSKHQPMGHDKKSLGPPSSSL 720

  Fly   684 PPVG-----------SGNSSSGSGSSKPM--------LPPHKKQIPHG--GDLLTNPGE------ 721
            |.||           :|:||:.|.:|..:        :|||  |.|.|  |.|..|.|.
Mosquito   721 PMVGGTTNLSSTGSNNGSSSNNSHTSHNLKRALDGTAMPPH--QDPSGPLGSLTGNGGNTHSSGN 783

  Fly   722 -----SGSLKRPN-----------------------EISGSQYGLNKLDEIDNSNMPREKL---- 754
                 |...|||:                       |.|||.:       :.:|..|.::|
Mosquito   784 AGGLLSSQAKRPHPSNEQIRQDDGTDFREQKVRRTAEPSGSSF-------LPSSGSPSDQLFNSS 841

  Fly   755 -------RKLDTTTGLPTYPN----------YEEKHTPL--------NMSNGIETTPDLVRSLLK 794
                   .|:|.::.|..:.:          .:.|.:.|        |..|||||...||.||||
Mosquito   842 FDLASTFDKMDDSSSLFNFNDPGSLLSQPLLSDSKPSTLAKSGGIFSNTINGIETNAALVSSLLK 906

  Fly   795 ESLC-----------------PSN----------------------ASLLKPDALTMP---GLKP 817
            |||.                 ||:                      |:..||...:|.   ||.|
Mosquito   907 ESLFNETPKFGSLYGGTSDPPPSSGSRTDVTDSKPLDTTGGSSAQPANETKPQLASMESLLGLPP 971

  Fly   818 ------------------PAELLEPMPAPATI-------KKEQGITPMTSLASGP-----APMDL 852
                              |.:..:|...|.:.       ..:.|..|..:.|:.|     ||...
Mosquito   972 TSAASGQQQLPTAAGGGGPNDATQPGAVPPSYPWVTTGNAAQMGDAPAAATATAPPTAALAPASA 1036

  Fly   853 EVPTKQAGEIKEESS-------------SKSEKKKKKDKHKHKEKDKSKDKTEKEERKKHKKDKQ 904
            :|..:|..:....:|             |||||||||:|||||||||:||: ::||:|||||||.
Mosquito  1037 DVAAQQQQQPAATASTASDPDTDTGGHRSKSEKKKKKEKHKHKEKDKTKDR-DREEKKKHKKDKD 1100

  Fly   905 KDRS------------------------------------------------------------G 909
            |.|.                                                            |
Mosquito  1101 KHRDRERDREKGDHHAGATGAGPDGAGAGHQGVGHSAPQDPPGPIKIKLNRAILPPSVDGVGLHG 1165

  Fly   910 SGGSKDSSLPNEPLKMVIKNP-------------------------------NGSLQAGASAPIK 943
            ||.:......|:.||  ||.|                               .|.:..|.||.:|
Mosquito  1166 SGSAPSGGPANDGLK--IKIPKDRLSGSSSLPGGGGSAAAGGSSHGGGGGPSGGGVGGGGSASLK 1228

  Fly   944 LKISKNKVEPNNYSAAA---GLPGAIGYGLPPTTATTTSASIGAAAPVLPPYGAGGGGYSSSGGS 1005
            |||||:|:|..|.||.:   |..|.||.|          .::|||       |...||.|:.||
Mosquito  1229 LKISKDKIEHYNISATSDGGGGTGGIGSG----------GALGAA-------GLPMGGPSAMGG- 1275

  Fly  1006 SSGGSSKKKHSDRDRDKESKKNKS-------QDYAKYNGAGGGIFNPLGGAGAAPNMSGGMGAPM 1063
            ..|..||||..|||:|:|..|:||       :..::.||..||     |.|.:..:.|......:
Mosquito  1276 PGGSGSKKKDKDRDKDREKSKSKSSSSSSSAEHGSRQNGGSGG-----GSAASGNSSSKSSSKNL 1335

  Fly  1064 STAVPP--------------SMLLAPTGAVPPSAAGLAP 1088
            ||...|              :..:..|.|...|.||:.|
Mosquito  1336 STLQQPQQQQQQQQYGMYNANQSMQATNAAMASMAGMVP 1374

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CycT	NP_524127.2	CYCLIN_CCNT_rpt1	45..174	CDD:410241	95/132 (72%)
		CYCLIN_CCNT_rpt2	179..268	CDD:410242	77/88 (88%)
CycT	XP_316716.4	None