Protein Alignment CycT and Ccnt1

DIOPT Version :10

• Sequence 1: NP_524127.2
• Gene: CycT / 39961
• FlyBaseID: FBgn0025455
• Length: 1097
• Species: Drosophila melanogaster
• Sequence 2: NP_033963.1
• Gene: Ccnt1 / 12455
• MGIID: 1328363
• Length: 724
• Species: Mus musculus
• Alignment Length: 809
• Identity: 268/809 - (33%)
• Similarity: 354/809 - (43%)
• Gaps: 226/809 - (27%)

  Fly    34 NNNLPFEKDKIWYFSNDQLANSPSRRCGIKGDDELQYRQMTAYLIQEMGQRLQVSQLCINTAIVY 98
            |||      |.|||:.:||.||||||.|:..|.||.|||..|.|:|:|||||.||||.|||||||
Mouse     7 NNN------KRWYFTREQLENSPSRRFGVDSDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVY 65

  Fly    99 MHRFYAFHSFTHFHRNSMASASLFLAAKVEEQPRKLEHVIRAANKC------LPPTTEQNYAELA 157
            |||||...|||.|||.|||.|:|||||||||||:||||||:.|:.|      ||.|..:.|.:..
Mouse    66 MHRFYMIQSFTQFHRYSMAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQV 130

  Fly   158 QELVFNENVLLQTLGFDVAIDHPHTHVVRTCQLVKACKDLAQTSYFLASNSLHLTSMCLQYRPTV 222
            |:||..|:::||||||::.|||||||||:..|||:|.|||||||||:|:||||||:..|||.|.|
Mouse   131 QDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPV 195

  Fly   223 VACFCIYLACKWSRWEIPQSTEGKHWFYYVDKTVSLDLLKQLTDEFIAIYEKSPARLKSKLNSIK 287
            |||.||:||||||.||||.||:||||:.|||.||:|:||.:||.||:.|.||:|:|||...|
Mouse   196 VACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPSRLKRIRN--- 257

  Fly   288 AIAQGASNRTANSKDKPKEDWKITEMMKGYHSNITTPPELLNGNDSRDRDRDRERERERERDPSS 352
                                |      :.|.:.:.|.|:        ||..|   |...|:...:
Mouse   258 --------------------W------RAYQAAMKTKPD--------DRGAD---ENTSEQTILN 285

  Fly   353 LLPPPAMVPQQRRQDGGHQRSSSVSGVPGSSSSSSSSSHKMPNYPGGMPPDAHTDH--------- 408
            ::                .::||.:.:.|..|.|::|:..:|:.|......:....
Mouse   286 MI----------------SQTSSDTTIAGLMSMSTASTSAVPSLPSSEESSSSLTSVDMLQGERW 334

  Fly   409 KSKQPGYNNRMPSSHQRSSSSGL----------GSSGSGSQRSSSSS------------------ 445
            .|.||.:.......|:.|.|..|          |||..|||:.:|.|
Mouse   335 LSSQPPFKLEAAQGHRTSESLALIGVDHSLQQDGSSAFGSQKQASKSVPSAKVSLKEYRAKHAEE 399

  Fly   446 --------------------------------SS--------SSQQPGRPSMPVDYHKSSRGMPP 470
                                            ||        ||:.|.||.:......:.:...|
Mouse   400 LAAQKRQLENMEANVKSQYAYAAQNLLSHDSHSSVILKMPIESSENPERPFLDKADKSALKMRLP 464

  Fly   471 VGVGMPPHGSHKMTSGSKPQQPQQQPVPHPSASNSSA---SGMSSKDKSQSNKMYPNAPPPYSN- 531
            |..|      .|..| |||::.:.:...|.:....::   |...|::..:..:.:|:....:.|
Mouse   465 VASG------DKAVS-SKPEEIKMRIKVHSAGDKHNSIEDSVTKSREHKEKQRTHPSNHHHHHNH 522

  Fly   532 --------SAPQNPLMSRGGYPGASNGSQ-----------------------PPPPAGYG--GH- 562
                    ..|..|:..|...|..|:.:.                       ||...|..  .|
Mouse   523 HSHRHSHLQLPAGPVSKRPSDPKHSSQTSTLAHKTYSLSSTLSSSSSTRKRGPPEETGAAVFDHP 587

  Fly   563 ----RSKSGSTVHGMPPFE--QQLPYSQSQSYGHMQQQP-----VPQSQQQQMPPEASQHSLQSK 616
                :|...|.....||..  .|||...|.:.|....||     ||..:..:.||.|:.|
Mouse   588 AKIAKSTKSSLNFPFPPLPTMTQLPGHSSDTSGLPFSQPSCKTRVPHMKLDKGPPGANGH----- 647

  Fly   617 NSLFSPEWPDIKKEPMSQSQPQPFNGLLPPPAPP---GHDYKLNSHPRDKESPKKERLTPTKKDK 678
            |:..|.::.|......|....|   |:.|..||.   .|.|....:||......:...|    ||
Mouse   648 NATQSIDYQDTVNMLHSLLSAQ---GVQPTQAPAFEFVHSYGEYMNPRAGAISSRSGTT----DK 705

  Fly   679 HRPVMPPVGSGNSSSGSGSSKPMLPPHKK 707
            .||  ||:.|        ...|.|||..|
Mouse   706 PRP--PPLPS--------EPPPPLPPLPK 724

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CycT	NP_524127.2	CYCLIN_CCNT_rpt1	45..174	CDD:410241	84/134 (63%)
		CYCLIN_CCNT_rpt2	179..268	CDD:410242	63/88 (72%)
Ccnt1	NP_033963.1	CYCLIN_SF	10..147	CDD:477360	85/136 (63%)
		CYCLIN_CCNT1_rpt2	151..259	CDD:410300	75/136 (55%)
		Nuclear localization signal. /evidence=ECO:0000255	253..270		5/45 (11%)
		Histidine-rich domain (HRD). /evidence=ECO:0000250|UniProtKB:O60563	479..549		10/69 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	483..586		13/102 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	691..724		14/46 (30%)