DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CycT and Ccnk

DIOPT Version :9

Sequence 1:	NP_001261992.1	Gene:	CycT / 39961	FlyBaseID:	FBgn0025455	Length:	1097	Species:	Drosophila melanogaster
Sequence 2:	NP_033962.2	Gene:	Ccnk / 12454	MGIID:	1276106	Length:	582	Species:	Mus musculus

Alignment Length:	705	Identity:	165/705 - (23%)
Similarity:	270/705 - (38%)	Gaps:	188/705 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 PITANNNLPFEKDKIWYFSNDQLANSPSRRCGIKGDDELQYRQMTAYLIQEMGQRLQVSQLCINT 94
            |...:.||...| ..||:....||::||:..|:....|.:||:..|..|.::|.||.:....:.|
Mouse    10 PSVTSANLDHTK-PCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLAT 73

  Fly    95 AIVYMHRFYAFHSFTHFHRNSMASASLFLAAKVEEQPRKLEHVIRAANKCLPPTTEQNYAELA-- 157
            .|:|.||||.||||..|.|....:..||||.||||.|:|.:.:|:.|...|   .:..:.:..
Mouse    74 GIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLL---NDVQFGQFGDD 135

  Fly   158 --QELVFNENVLLQTLGFDVAIDHPHTHVVRTCQLVKACKD----LAQTSYFLASNSLHLTSMCL 216
              :|::..|.:||||:.||:.::||:..:::..:.:|..|:    |.|.::...::|| .|::.|
Mouse   136 PKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSL-CTTLSL 199

  Fly   217 QYRPTVVACFCIYLACKWSRWEIPQSTEG---KHWFYYVDKTVSLDLLKQLTDEFIAIYEK---- 274
            |:.|.::|...:|||.:..::||.:.|..   :.|:....:.|.:|:|:.:..:.:.:|.:
Mouse   200 QWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQ 264

  Fly   275 ----SPARLKS--KLNSIKAIAQGASNRTANSKDKPKEDWKITEMMKGYHSNITTPPELLNGNDS 333
                :|.:|:.  .|.....:.||..::.:...:..:...|.::............|:..:...|
Mouse   265 MPHHTPHQLQQPPSLQPTPQVPQGPQSQPSQGSEAAQPPQKDSQQSAQQQQQQAQQPKKPSPQPS 329

  Fly   334 RDRDRDR-----ERERERERDPSSLLPPPAMVPQQRRQDGGH----------QRSSSVSGVPGSS 383
            ..|...|     .:|..:..:|    |||..:|   :.:..|          .|...::...|.:
Mouse   330 PPRQAKRAVVVSPKEENKATEP----PPPPKIP---KLEATHPPLPPAHPPPDRKPPLAPALGEA 387

  Fly   384 SSSSS-SSHKMPNYPGGMPPDAHTDHKSKQPGYNNRMPSSHQRSSSSGLGS-----SGSGSQRSS 442
            .::.. .:..:|...  :||.||.....:.|...:|.|.....|..:|:.:     ||.|.|  |
Mouse   388 EATGPVETSDLPKVQ--IPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQ--S 448

  Fly   443 SSSSSSSQQPGRPSMPVDYHKSSRGMPPVGVGMPPHGSHKMTSGSKPQQPQQQPVPHPSASNSSA 507
            ..|...::.|...::|..|.      ||..:...||        ..|..|...|||.|.||
Mouse   449 LQSMMKTEGPSYGALPPAYG------PPAHLTYHPH--------VYPPNPPPPPVPPPPAS---- 495

  Fly   508 SGMSSKDKSQSNKMYPNAPPPYSNSAPQNPLMSRGGYPGASNGSQPPPPAGYGGHRSKSGSTVHG 572
                             .|||  ...|..|     |||       ||||. |..:
Mouse   496 -----------------FPPP--TIPPPTP-----GYP-------PPPPT-YNPN---------- 518

  Fly   573 MPPFEQQLPYSQSQSYGHMQQQPVPQSQQQQMPPEASQHSLQSKNSLFSPEWPDIKKEPMSQSQP 637
            .||...:||.:.:                  :||                             .|
Mouse   519 FPPPPPRLPPTHA------------------VPP-----------------------------HP 536

  Fly   638 QPFNGL----LPPPA-PPGHDYKLNSHPRDKESPKKERLTPTKKDKHRPVMPPVG 687
            .|..||    .|||| |||           .:.|....:.|       |.|||||
Mouse   537 PPGLGLPPASYPPPAVPPG-----------GQPPVPPPIPP-------PGMPPVG 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycT	NP_001261992.1	Cyclin_N	42..176	CDD:278560	49/137 (36%)
CycT	NP_001261992.1	CYCLIN	<203..>251	CDD:214641	14/50 (28%)
Ccnk	NP_033962.2	CCL1	25..>217	CDD:227640	64/195 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1437076at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920