Protein Alignment CG7542 and GZMH

DIOPT Version :10

• Sequence 1: NP_648995.3
• Gene: CG7542 / 39960
• FlyBaseID: FBgn0036738
• Length: 270
• Species: Drosophila melanogaster
• Sequence 2: NP_219491.1
• Gene: GZMH / 2999
• HGNCID: 4710
• Length: 246
• Species: Homo sapiens
• Alignment Length: 240
• Identity: 72/240 - (30%)
• Similarity: 101/240 - (42%)
• Gaps: 27/240 - (11%)

  Fly    27 ITNGEPAEVGQFPYQAGLNVSFGNWSTWCGGTLISHYWIITAAHCMDGAESVTVYLGAINIGDES 91
            |..|..|:....||.|.:..........|||.|:...:::|||||.  ..|:.|.|||.|| .|.
Human    21 IIGGHEAKPHSRPYMAFVQFLQEKSRKRCGGILVRKDFVLTAAHCQ--GSSINVTLGAHNI-KEQ 82

  Fly    92 EEGQERIMVEKSGIIVHSNYMASTVVNDISLIRLPAFVGFTDRIRAASLP----RRLNGQFPTYE 152
            |..|:.|.|::.  |.|..|......|||.|::|.....:|..:|...||    :...||.
Human    83 ERTQQFIPVKRP--IPHPAYNPKNFSNDIMLLQLERKAKWTTAVRPLRLPSSKAQVKPGQL---- 141

  Fly   153 SIRAFASGWGRESDASDSVSPVLRYVEMPIMPHSLCRMYWSGAVSEKM-ICMSTTSGKST-CHGD 215
               ...:|||..|  ..:::..|:.|.:.:.....|...:.|..|... ||:.......| ..||
Human   142 ---CSVAGWGYVS--MSTLATTLQEVLLTVQKDCQCERLFHGNYSRATEICVGDPKKTQTGFKGD 201

  Fly   216 SGGPLVYKQGNSSYLIGSTSFGTSMGCQVGFPAVFTRISSYLDWI 260
            ||||||.|    ....|..|:|...|..   |.|:.::|.:|.||
Human   202 SGGPLVCK----DVAQGILSYGNKKGTP---PGVYIKVSHFLPWI 239

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7542	NP_648995.3	Tryp_SPc	27..263	CDD:238113	72/240 (30%)
GZMH	NP_219491.1	Tryp_SPc	21..242	CDD:238113	72/240 (30%)
		Mediates the preference for acidic residues at the P3' and P4' sites	46..48		0/1 (0%)