Protein Alignment LLGL1 and l(2)gl

DIOPT Version :9

• Sequence 1: XP_011522151.1
• Gene: LLGL1 / 3996
• HGNCID: 6628
• Length: 1105
• Species: Homo sapiens
• Sequence 2: NP_001245801.1
• Gene: l(2)gl / 33156
• FlyBaseID: FBgn0002121
• Length: 1161
• Species: Drosophila melanogaster
• Alignment Length: 1146
• Identity: 412/1146 - (35%)
• Similarity: 622/1146 - (54%)
• Gaps: 158/1146 - (13%)

Human     1 MMKFRFRRQGADP--QREKLKQELFAFNKTVEHGFPNQPSALAFDPELRIMAIGTRSGAVKIYGA 63
            |:|| .|.:|..|  .|.:|:::|||:.||.:||||::|||||:||.|::|||||::||:|::|.
  Fly     1 MLKF-IRGKGQQPSADRHRLQKDLFAYRKTAQHGFPHKPSALAYDPVLKLMAIGTQTGALKVFGQ 64

Human    64 PGVEFTGLH---RDAAT---VTQMHFLTGQGRLLSLLDDSSLHLWEIVHHNGCAHLEEALSFQLP 122
            ||||..|.|   .::|:   |..:.::.|.||:|||...:.|.|||.|         .|....:.
  Fly    65 PGVELYGQHTLLNNSASELNVQLLEWVYGTGRILSLTAANQLILWEPV---------GATLLPIK 120

Human   123 SRPGFDGASAPLSLTRVTVVLLVAASDIAALGTEGSSVFFLDVTTLTLLEGQTLAPGEVLRSVPD 187
            :.| |||     .|.:|:.:....:.|:..:||||.:::.||:.|.|:.| ..:....||..||.
  Fly   121 TLP-FDG-----KLKKVSSLCCSLSKDLLWIGTEGGNIYQLDLHTFTIKE-PVIYHDVVLEQVPP 178

Human   188 DYRCGKALGPVESLQGHLRDPTKILIGYSRGLLVIWNQASQCVDHIFL--GNQQLESLCWGRDSS 250
            .|:...  |.:||::.....|:|:|:.|:|||.|:|:..|..|...::  |:.|...|....:.|
  Fly   179 AYKLNP--GAIESIRQLPNSPSKLLVAYNRGLCVLWDFESASVQRAYIAPGHGQSVGLTVNFEGS 241

Human   251 TVVSSHSDGSYAVWSVDAGSFPTLQPTVATTPYGPFPCKAINKILWRNCESGGHFIIFSGGMPRA 315
            .....|:|||||.||:|....|:   .|...||||.|||:||: |::........|:|||||||:
  Fly   242 EFTWYHADGSYATWSIDNPEPPS---NVNYVPYGPDPCKSINR-LYKGKRRSNDVIVFSGGMPRS 302

Human   316 SYGDRHCVSVLRAE-TLVTLDFTSRIIDFFTVHSTRPEDEFDDPQALAVLLEEELVVLDLQTPGW 379
            :|||.:||||..:: ..|.|||||::||||...    |:..|..:.|.|||||||...||..|..
  Fly   303 AYGDHNCVSVHASDGHKVCLDFTSKVIDFFVTF----ENNRDVAEVLVVLLEEELCAYDLTDPNI 363

Human   380 PAVPAPYLAPLHSSAITCSAHVASVPAKLWARIVSAGEQQSPQPVSSALSWPITGGR---NLAQE 441
            .|:.||||..:|:||:||:...:.|...::..|:.||::|...  .|.:|||||||.   ||.:.
  Fly   364 CAIKAPYLHSVHASAVTCNYLASEVVQSVYESILRAGDEQDID--YSNISWPITGGTLPDNLEES 426

Human   442 PSQRG-----LLLTGHEDGTVRFWDASGVALRPLYKLSTAGLFQTDCEH-----ADSLAQAAEDD 496
            ..:..     :||||||||:|:|||.:||.|:|:|...|:.:|.::.:.     ||..|:..::.
  Fly   427 VEEDATKLYEILLTGHEDGSVKFWDCTGVLLKPIYNFKTSSIFGSESDFRDDAAADMSAEQVDEG 491

Human   497 WPPFRKVGCFDPYSDDPRLGVQKVALCKYTAQMVVAGTAGQVLVLELSDVPVEQAVSVAIIDLLQ 561
            .|||||.|.||||||||||.|:|:|.|..|.|::|.|||||:::.:..|:|.:.::....::|:.
  Fly   492 EPPFRKSGLFDPYSDDPRLAVKKIAFCPKTGQLIVGGTAGQIVIADFIDLPEKVSLKYISMNLVS 556

Human   562 DREGFTWKGHERLSPRTGPLPWPA------GFQPRVLVQCLPPAAVTAVTLHTEWSLVAFGTSHG 620
            ||:||.||||::|:.|:..|...|      |.....::|.||||::|.:.|...|.||:.||:||
  Fly   557 DRDGFVWKGHDQLNVRSNLLDGEAIPTTERGVNISGVLQVLPPASITCMALEASWGLVSGGTAHG 621

Human   621 FGLFDYQRKSPVLARCTLHPNDSLAMEGPLSRVKSLKKSLRQSFRRIRKSRVSGKKRAANASSKL 685
            ..|||::...||..||||:|||.......|||.||.|||||:|||::||.|          |::.
  Fly   622 LVLFDFKNFVPVFHRCTLNPNDLTGAGEQLSRRKSFKKSLRESFRKLRKGR----------STRT 676

Human   686 QEANAQLAEQACPHDVEMTPVQRRIEPRSADDSLSGVVRCLYFADTFLRDGAHHGPTMWAGTNSG 750
            .::|      ..|..:|..||:|:||.|.|||.|..:||||.||.|::.:.....||:|:.||:.
  Fly   677 NQSN------QVPTTLEARPVERQIEARCADDGLGSMVRCLLFAKTYVTNVNITSPTLWSATNAS 735

Human   751 SVFAYALEVPAA--------AVGGEKRPE--QAVEAVLGKEVQLMHRAPVVAIAVLDGRGRPLPE 805
            :|..:.|.:|.|        :..|...|.  :.:.|.|.||:||.||||||.|::.|..|.|:.:
  Fly   736 TVSVFLLHLPPAQTAATAVPSASGNAPPHMPRRISAQLAKEIQLKHRAPVVGISIFDQAGSPVDQ 800

Human   806 PYEASRDLAQAPDMQGGHAVLIASEEQFKVFTLPKVSAKTKFKLTAHEGCRVRKVALATFA---- 866
                   |....:....|.||||||||||||:||::....|:||||:||.|:|::...:|:
  Fly   801 -------LNAGENGSPPHRVLIASEEQFKVFSLPQLKPINKYKLTANEGARIRRIHFGSFSCRIS 858

Human   867 ------------------------------SVAC---EDYAETCLACLTNLGDVHVFSVPGLRPQ 898
                                          |:|.   :.|.||.|.||||:||:.|.|||.|:.|
  Fly   859 PETLQSMHGCSPTKSTRSHGDGEADPNISGSLAVSRGDVYNETALICLTNMGDIMVLSVPELKRQ 923

Human   899 VHYSCIRKEDISGIASCVFTRHGQGFYLISPSEFERFSLSARNITEPLCSLDINWPRDATQASYR 963
            ::.:.:|:|||:|::|..||..|:..|::|.||.:|.:|:...:.:|...:.:. |.:..::...
  Fly   924 LNAAAVRREDINGVSSLCFTNSGEALYMMSSSELQRIALATSRVVQPTGVVPVE-PLENEESVLE 987

Human   964 IRESPKLSQANGTPSI-----LLAPQSLDGSPDPAHSMGPGPQVQRVLRVLVGADDLLPVDTPEP 1023
            ..::....:......:     :..|..:.....||........||:|..|.:.
  Fly   988 ENDAENNKETYACDEVVNTYEIKNPSGISICTRPAEENVGRNSVQQVNGVNIS------------ 1040

Human  1024 PEAALSPMSIDSATSADTTLDTT-GDVTVEDVKDFLGKART 1063
                      :|...|:.|:.:: ||:||:.|:|.|....|
  Fly  1041 ----------NSPNQANETISSSIGDITVDSVRDHLNMTTT 1071

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LLGL1	XP_011522151.1	LLGL	280..379	CDD:285555	48/99 (48%)
l(2)gl	NP_001245801.1	WD40 repeat	39..78	CDD:293791	22/38 (58%)
		WD40 repeat	84..126	CDD:293791	15/51 (29%)
		WD40 repeat	131..174	CDD:293791	12/43 (28%)
		WD40 repeat	188..224	CDD:293791	13/35 (37%)
		LLGL	268..>338	CDD:285555	36/74 (49%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158370
Domainoid	1	1.000	310	1.000	Domainoid score	I1326
eggNOG	1	0.900	-	-		E1_KOG1983
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31220
Inparanoid	1	1.050	654	1.000	Inparanoid score	I783
Isobase	1	0.950	-	0.928771	Normalized mean entropy	S6106
OMA	1	1.010	-	-		QHG48039
OrthoDB	1	1.010	-	-		D113391at33208
OrthoFinder	1	1.000	-	-		FOG0000702
OrthoInspector	1	1.000	-	-		otm40558
orthoMCL	1	0.900	-	-		OOG6_104800
Panther	1	1.100	-	-	O	PTHR10241
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4628
SonicParanoid	1	1.000	-	-		X453
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750