Protein Alignment LLGL1 and lgl-1

DIOPT Version :9

• Sequence 1: XP_011522151.1
• Gene: LLGL1 / 3996
• HGNCID: 6628
• Length: 1105
• Species: Homo sapiens
• Sequence 2: NP_508169.2
• Gene: lgl-1 / 180435
• WormBaseID: WBGene00018987
• Length: 941
• Species: Caenorhabditis elegans
• Alignment Length: 988
• Identity: 212/988 - (21%)
• Similarity: 408/988 - (41%)
• Gaps: 134/988 - (13%)

Human    12 DPQREKLKQELFAFNKTVEHGFPNQPSALAFDPELRIMAIGTRSGAVKIYGAPGVEFT-GLHRDA 75
            :|:...::| ...|::....||.:  ..:|||.....:.||:::|.|..||..|..:| .|.:|:
 Worm    15 EPEEHAIEQ-YAVFDEGNRGGFTS--DVVAFDYHNGCVVIGSKNGEVTFYGYRGASWTVSLSKDS 76

Human    76 ---ATVTQMHFLTGQGRLLSLLDDSSLHLWEIVH-HNGCAHLEEALSFQLPSRPGFDGASAPLSL 136
               |.:..:.|::  ..:..:|.|..|.:  .:| .:|....:|.|.|....:..:|       :
 Worm    77 ENKARIEHIFFIS--SNIALVLCDGQLII--PIHIKDGVITKKEELRFNENHKSKWD-------I 130

Human   137 TRVTVVLLVAASDIAALGTEGSSVFFLDVTTLTLLEGQTLAPGEVL-------RSVPDDYRCGKA 194
            |.|..:    :.|..||      ||.:: .|:..::.:|| ..|||       :.:|||    ..
 Worm   131 THVQKL----SDDTFAL------VFSMN-NTIYRIKSKTL-KSEVLVKAEDFEKWLPDD----TE 179

Human   195 LGPVESLQGHLRDPTKILIGYSRGLLVIWNQASQCVDHIFLGN---QQLESLCWGRDSSTVVS-- 254
            |..:..|.   ..|:.:::....|.:.::|: ||.|....|.|   :.::.|.|..:....|:
 Worm   180 LASITCLP---EKPSILMLIAENGCVGVFNE-SQFVMKTSLRNYEDEAIQKLHWSSEKKKNVAFG 240

Human   255 SHSDGSYAVWSVDAGSFPTLQP----TVATTPYGPFPCKAIN--KILWRNCESGGHFIIFSGGMP 313
            ...:..|..|....|....:..    ..:...:||:||..|.  .:.....:...:|:|:.||..
 Worm   241 ISCNNKYTKWEFTVGKDCQISAQEVNVYSANQFGPYPCHQIRHFSVCADASDPNENFLIYQGGKS 305

Human   314 RASYGDRHCVSVLRAETLVTLDFTSRIIDFFTVHSTRPEDEFDDPQALAVLL---EEELVVLDLQ 375
            ...|.||..:::...:.:..|:.:|.|:....|..:     ::|.:...|:|   :.|::.:||:
 Worm   306 SGKYDDRDLITISHGDFVEKLELSSEIVGIVGVSGS-----YEDCKKSGVVLICTKCEIIGIDLE 365

Human   376 TPGWPAVPAPYLAPLHSSAITCSAHVASVPAKLWARIVSAGEQQSPQPVSSALSWPITGGRNLA- 439
            ......:...:...:::|..|..:....:...:|.|:.||.:........|...||:...:.:.
 Worm   366 RESLNMMQPKHFLSINNSTPTTHSRAIEIEENVWNRLESASKSYWETNQMSTRDWPLNFQKKIVT 430

Human   440 ----QEPSQRGLLLTGHEDGTVRFWDASGVALRPLYKLSTAGLFQ--TDCEHADS-LAQAAEDDW 497
                |..|.|.:.|:||.:|.:..|.:.||.:..:..:.|:..|.  :..::.|| ...:.|...
 Worm   431 DANHQRASYRQVYLSGHSNGNICIWSSGGVGMSLMLVIRTSLEFDGASSFDNEDSNYYNSDEKPE 495

Human   498 PPFRKVGCFDPYSDDPRLGVQKVALCKYTAQMVVAGTAGQVLVLELSD----VPVEQAVSVAIID 558
            .|.||:|.:||:.||..:.:.:|.....:..::.....|.||:.||.|    :...:|..::..:
 Worm   496 KPVRKIGLYDPFDDDEEMCITRVHFDPKSGIVIGTNRGGYVLMYELWDSARTLTHWEATPISCNN 560

Human   559 LLQDREGFTWKGHERLSPRTGPLPWPAGFQPRV-------LVQCLPPA-AVTAVTLHTEWSLVAF 615
            ...|..      ...|.||...|.:.||:|.|:       ||..:.|: .:|.:....::..:|.
 Worm   561 SPPDTR------KRALKPRKAELKYNAGYQIRLKNESDLPLVFSMHPSHRITDIVYLHKYHCLAV 619

Human   616 GTSHGFGLFDYQRKSPVLARCTLHPND--SLAMEGPLSRVKSLKKSLRQSFRRIRKSRVSGKKRA 678
            |::.|..:.|......|.|......|:  |........|.||||||||::|||.:|    |.:..
 Worm   620 GSNFGIVMLDVNFGYLVYANSFNDDNNDSSNVSANQFQRFKSLKKSLRKTFRRKKK----GTETL 680

Human   679 ANASSKLQEANAQLAEQACPHDV-----EMTPVQRRIEPRS--------ADDSLSGVVRCLYFAD 730
            .::...:..::..:..:..|..:     |...::|.||.|.        |::| .|.|.||....
 Worm   681 MDSGGAVASSSNHVQHETSPKRIDDFEEEEVFMERPIEAREELGVLDCYAENS-KGTVTCLRMMR 744

Human   731 TFLRDGAHHGPTMWAGTNSGSVFAYALEVPAAAVGGEKRPEQAVEAVLGKEVQLMHRAPVVAIAV 795
            ..:.|..:....:..|.:.|||:.||:......:....:.||.      |::.:.|:.|||.:.:
 Worm   745 FPVLDDKNVDDIIAVGLHEGSVYFYAISEHDVGLRMTFKAEQI------KKLSIPHKQPVVNLDI 803

Human   796 LDGRGRPLPEPYEASRDLAQAPDMQGGHAVLIASEEQFKVFTLPKVSAKTKFKLTAHEGCRVRKV 860
            .:..|.     :.||.            .:::.:|||.:::....:..:..:|:||.||.:::..
 Worm   804 TNEEGY-----FSAST------------RIVVITEEQLRIYNCQPMVKRDSYKITALEGLKIKNG 851

Human   861 ALATFASVACEDYAETCLACLTNLGDVHVFSVPGLRPQVHYSCIRKEDISGIASCVFTRHGQGFY 925
            .:|...:....:..|:.:..:.|.|.:.|.||...........|...|:..:.|...:|.|...:
 Worm   852 MVARILNKKNSNNFESFVVLVANDGSLRVHSVQKASSFESRKFIDPIDVMALNSSCLSRDGDVAF 916

Human   926 LISPSEFERFSLS 938
            ||..||.:|.:::
 Worm   917 LIKSSELQRSTVN 929

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LLGL1	XP_011522151.1	LLGL	280..379	CDD:285555	22/103 (21%)
lgl-1	NP_508169.2	LLGL	273..364	CDD:369834	20/95 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161470425
Domainoid	1	1.000	99	1.000	Domainoid score	I4899
eggNOG	1	0.900	-	-		E1_KOG1983
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.928771	Normalized mean entropy	S6106
OMA	1	1.010	-	-		QHG48039
OrthoDB	1	1.010	-	-		D113391at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10241
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.770