DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LLGL1 and Llgl1

DIOPT Version :9

Sequence 1:	XP_011522151.1	Gene:	LLGL1 / 3996	HGNCID:	6628	Length:	1105	Species:	Homo sapiens
Sequence 2:	NP_001152877.1	Gene:	Llgl1 / 16897	MGIID:	102682	Length:	1062	Species:	Mus musculus

Alignment Length:	1059	Identity:	942/1059 - (88%)
Similarity:	980/1059 - (92%)	Gaps:	23/1059 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     1 MMKFRFRRQGADPQREKLKQELFAFNKTVEHGFPNQPSALAFDPELRIMAIGTRSGAVKIYGAPG 65
            |||||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||
Mouse     1 MMKFRFRRQGADPQREKLKQELFAFHKTVEHGFPNQPSALAFDPELRIMAIGTRSGAVKIYGAPG 65

Human    66 VEFTGLHRDAATVTQMHFLTGQGRLLSLLDDSSLHLWEIVHHNGCAHLEEALSFQLPSRPGFDGA 130
            |||||||||||||||||||.||||||:||||||||||||:||||||||||.|||..||||.||.|
Mouse    66 VEFTGLHRDAATVTQMHFLPGQGRLLTLLDDSSLHLWEIIHHNGCAHLEEGLSFHPPSRPSFDNA 130

Human   131 SAPLSLTRVTVVLLVAASDIAALGTEGSSVFFLDVTTLTLLEGQTLAPGEVLRSVPDDYRCGKAL 195
            |.|.||||||||||| |.:.||||||..|:|||||.||.|||||||:|..|||||||||||||||
Mouse   131 SFPASLTRVTVVLLV-AGNTAALGTESGSIFFLDVATLALLEGQTLSPDVVLRSVPDDYRCGKAL 194

Human   196 GPVESLQGHLRDPTKILIGYSRGLLVIWNQASQCVDHIFLGNQQLESLCWGRDSSTVVSSHSDGS 260
            ||||||||||:||:||||||||||||||:||:|.||::|||||||||||||||.|:::|||||||
Mouse   195 GPVESLQGHLQDPSKILIGYSRGLLVIWSQATQSVDNVFLGNQQLESLCWGRDGSSIISSHSDGS 259

Human   261 YAVWSVDAGSFPTLQPTVATTPYGPFPCKAINKILWRNCESGGHFIIFSGGMPRASYGDRHCVSV 325
            ||:||.|.||.|||||||.||||||||||||||||||:||||.||||||||||||||||||||||
Mouse   260 YAIWSTDTGSPPTLQPTVVTTPYGPFPCKAINKILWRSCESGDHFIIFSGGMPRASYGDRHCVSV 324

Human   326 LRAETLVTLDFTSRIIDFFTVHSTRPEDEFDDPQALAVLLEEELVVLDLQTPGWPAVPAPYLAPL 390
            ||||||||||||||:|||||||||:||||.|:|||||||||||||||||||||||||||||||||
Mouse   325 LRAETLVTLDFTSRVIDFFTVHSTQPEDECDNPQALAVLLEEELVVLDLQTPGWPAVPAPYLAPL 389

Human   391 HSSAITCSAHVASVPAKLWARIVSAGEQQSPQPVSSALSWPITGGRNLAQEPSQRGLLLTGHEDG 455
            ||||||||||||:||:|||||||||||||||||.|||||||||||||||||||||||||||||||
Mouse   390 HSSAITCSAHVANVPSKLWARIVSAGEQQSPQPASSALSWPITGGRNLAQEPSQRGLLLTGHEDG 454

Human   456 TVRFWDASGVALRPLYKLSTAGLFQTDCEHADSLAQAAEDDWPPFRKVGCFDPYSDDPRLGVQKV 520
            |||||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||:|||
Mouse   455 TVRFWDASGVALRPLYKLSTAGLFQTDCEHADSLAQAVEDDWPPFRKVGCFDPYSDDPRLGIQKV 519

Human   521 ALCKYTAQMVVAGTAGQVLVLELSDVPVEQAVSVAIIDLLQDREGFTWKGHERLSPRTGPLPWPA 585
            ||||||||||||||||||||||||:||.|.|||||.:|||||||||||||||||:|.||.|||||
Mouse   520 ALCKYTAQMVVAGTAGQVLVLELSEVPAEHAVSVANVDLLQDREGFTWKGHERLNPHTGLLPWPA 584

Human   586 GFQPRVLVQCLPPAAVTAVTLHTEWSLVAFGTSHGFGLFDYQRKSPVLARCTLHPNDSLAMEGPL 650
            |||||:|:||||||||||||||.||||||||||||||||||||||||||||||||||||||||||
Mouse   585 GFQPRMLIQCLPPAAVTAVTLHAEWSLVAFGTSHGFGLFDYQRKSPVLARCTLHPNDSLAMEGPL 649

Human   651 SRVKSLKKSLRQSFRRIRKSRVSGKKRAANASSKLQEANAQLAEQACPHDVEMTPVQRRIEPRSA 715
            |||||||||||||||||||||||||||...|||||||||||||||.||||:||||||||||||||
Mouse   650 SRVKSLKKSLRQSFRRIRKSRVSGKKRTPAASSKLQEANAQLAEQTCPHDLEMTPVQRRIEPRSA 714

Human   716 DDSLSGVVRCLYFADTFLRDGAHHGPTMWAGTNSGSVFAYALEVPAAAVGGEKRPEQAVEAVLGK 780
            ||||||||||||||||||||..|||||||||||||||||||||||||..||||||||||||||||
Mouse   715 DDSLSGVVRCLYFADTFLRDATHHGPTMWAGTNSGSVFAYALEVPAATAGGEKRPEQAVEAVLGK 779

Human   781 EVQLMHRAPVVAIAVLDGRGRPLPEPYEASRDLAQAPDMQGGHAVLIASEEQFKVFTLPKVSAKT 845
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   780 EVQLMHRAPVVAIAVLDGRGRPLPEPYEASRDLAQAPDMQGGHAVLIASEEQFKVFTLPKVSAKT 844

Human   846 KFKLTAHEGCRVRKVALATFASVACEDYAETCLACLTNLGDVHVFSVPGLRPQVHYSCIRKEDIS 910
            |||||||||||||||||||||||..||||||||||||||||||||||||||||||||||||||||
Mouse   845 KFKLTAHEGCRVRKVALATFASVMSEDYAETCLACLTNLGDVHVFSVPGLRPQVHYSCIRKEDIS 909

Human   911 GIASCVFTRHGQGFYLISPSEFERFSLSARNITEPLCSLDINWPRDATQASYRIRESPKLSQANG 975
            |||||||||||||||||||||||||||||||||||||||||:||::|||.  |::||||||||||
Mouse   910 GIASCVFTRHGQGFYLISPSEFERFSLSARNITEPLCSLDISWPQNATQP--RLQESPKLSQANG 972

Human   976 TPSILLAPQSLDGSPDPAHSMGPGPQVQRVLRVLVGADDLLPVDTPEPPEAALSPMSIDSATSAD 1040
            |..|:|||:|.:|||..|||.                    ..||.|||||||||:|||||.|.|
Mouse   973 TRDIILAPESCEGSPSSAHSK--------------------RADTMEPPEAALSPVSIDSAASGD 1017

Human  1041 TTLDTTGDVTVEDVKDFLG 1059
            |.||||||||||.||||||
Mouse  1018 TMLDTTGDVTVEYVKDFLG 1036

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LLGL1	XP_011522151.1	LLGL	280..379	CDD:285555	92/98 (94%)
Llgl1	NP_001152877.1	WD40 repeat	38..73	CDD:293791	34/34 (100%)
		WD 1	38..71		32/32 (100%)
		WD 2	78..119		36/40 (90%)
		WD40 repeat	116..174	CDD:293791	42/58 (72%)
		WD 3	139..175		27/36 (75%)
		WD40 repeat	182..234	CDD:293791	44/51 (86%)
		WD40	<195..>310	CDD:225201	96/114 (84%)
		WD 4	199..233		27/33 (82%)
		WD40 repeat	239..282	CDD:293791	33/42 (79%)
		WD 5	239..271		24/31 (77%)
		LLGL	279..378	CDD:285555	92/98 (94%)
		WD 6	289..331		39/41 (95%)
		WD 7	339..373		29/33 (88%)
		WD 8	395..473		74/77 (96%)
		WD 9	517..592		65/74 (88%)
		WD 10	601..662		59/60 (98%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	667..688		17/20 (85%)
		WD 11	722..782		55/59 (93%)
		WD 12	791..843		51/51 (100%)
		WD 13	848..901		50/52 (96%)
		WD 14	915..938		22/22 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	980..1002		12/41 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83968413
Domainoid	1	1.000	695	1.000	Domainoid score	I3853
eggNOG	1	0.900	-	-		E1_KOG1983
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31220
Inparanoid	1	1.050	1907	1.000	Inparanoid score	I1794
Isobase	1	0.950	-	0.928771	Normalized mean entropy	S6106
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG48039
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000702
OrthoInspector	1	1.000	-	-		oto122581
orthoMCL	1	0.900	-	-		OOG6_104800
Panther	1	1.100	-	-	LDO	PTHR10241
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4628
SonicParanoid	1	1.000	-	-		X453
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	18	18.240