Protein Alignment LLGL1 and llgl1

DIOPT Version :9

• Sequence 1: XP_011522151.1
• Gene: LLGL1 / 3996
• HGNCID: 6628
• Length: 1105
• Species: Homo sapiens
• Sequence 2: XP_002935892.2
• Gene: llgl1 / 100486472
• XenbaseID: XB-GENE-868457
• Length: 1052
• Species: Xenopus tropicalis
• Alignment Length: 1066
• Identity: 746/1066 - (69%)
• Similarity: 875/1066 - (82%)
• Gaps: 45/1066 - (4%)

Human     1 MMKFRFRRQGADPQREKLKQELFAFNKTVEHGFPNQPSALAFDPELRIMAIGTRSGAVKIYGAPG 65
            ||||||||||.||||||:||||||||||||||||||||:|||||.|||||||.:|||||||||||
 Frog     1 MMKFRFRRQGHDPQREKIKQELFAFNKTVEHGFPNQPSSLAFDPLLRIMAIGAKSGAVKIYGAPG 65

Human    66 VEFTGLHRDAATVTQMHFLTGQGRLLSLLDDSSLHLWEIVHHNGCAHLEEALSFQLPSRPGFDGA 130
            |||||||:|.|||||||||.|||||||||||:::||||:...:|.:||||..||.||.:||||.|
 Frog    66 VEFTGLHKDTATVTQMHFLPGQGRLLSLLDDNTMHLWELQQKDGSSHLEETRSFLLPGKPGFDCA 130

Human   131 SAPLSLTRVTVVLLVAASDIAALGTEGSSVFFLDVTTLTLLEGQTLAPGEVLRSVPDDYRCGKAL 195
            ::|.|.|||||:|:.|:.::|.|||||..|:|:.:.:|.|||.:||...|:::|:|::|||||.|
 Frog   131 NSPPSFTRVTVILITASCEVAGLGTEGGGVYFIQIPSLKLLEEKTLLQDEIVKSLPEEYRCGKTL 195

Human   196 GPVESLQGHLRDPTKILIGYSRGLLVIWNQASQCVDHIFLGNQQLESLCWGRDSSTVVSSHSDGS 260
            |||||||.|......|||||||||:|:|:|..:.|:|:|||||||||:.|||..::.:||||||.
 Frog   196 GPVESLQEHPCQRGTILIGYSRGLVVLWDQEGRKVEHLFLGNQQLESVFWGRKGTSFISSHSDGG 260

Human   261 YAVWSVDAGSFPTLQPTVATTPYGPFPCKAINKILWRNCESGGHFIIFSGGMPRASYGDRHCVSV 325
            |.||...:.|..|.||..:..|||||||||||||.||:..||..:||||||||||||||||||::
 Frog   261 YMVWEAASDSSTTSQPVTSKIPYGPFPCKAINKIQWRSSSSGNPYIIFSGGMPRASYGDRHCVTI 325

Human   326 LRAETLVTLDFTSRIIDFFTVHSTRPEDEFDDPQALAVLLEEELVVLDLQTPGWPAVPAPYLAPL 390
            |:.:.|||||||||::|||||...:.||:.|:|.||.||:||||||:||||||||.||.||||||
 Frog   326 LQGQNLVTLDFTSRVVDFFTVCPLKSEDDSDNPTALVVLVEEELVVIDLQTPGWPTVPTPYLAPL 390

Human   391 HSSAITCSAHVASVPAKLWARIVSAGEQQSPQPVSSALSWPITGGRNLAQEPSQRGLLLTGHEDG 455
            |||||||:.|:::|..|||.||:||||||:||  .|:::|||.||||||:||:||||||||||||
 Frog   391 HSSAITCAYHISNVTTKLWERIISAGEQQNPQ--FSSVNWPIDGGRNLAEEPAQRGLLLTGHEDG 453

Human   456 TVRFWDASGVALRPLYKLSTAGLFQTDCEHADSLAQAAEDDWPPFRKVGCFDPYSDDPRLGVQKV 520
            ||||||||||||||||||||||:|||||:|.:|..|:.:::||||||||||||||||||||:||:
 Frog   454 TVRFWDASGVALRPLYKLSTAGIFQTDCDHNESFNQSNDEEWPPFRKVGCFDPYSDDPRLGIQKI 518

Human   521 ALCKYTAQMVVAGTAGQVLVLELSDVPVEQAVSVAIIDLLQDREGFTWKGHERLSPRTGPLPWPA 585
            |||||:.:|:||||||||||::|:|..||..::||.:||||:|||||||||:||:||.|.|.:..
 Frog   519 ALCKYSGKMLVAGTAGQVLVMDLNDEKVEHTINVATVDLLQEREGFTWKGHDRLTPRNGSLFFQP 583

Human   586 GFQPRVLVQCLPPAAVTAVTLHTEWSLVAFGTSHGFGLFDYQRKSPVLARCTLHPNDSLAMEGPL 650
            |||...||||:||||||||.||:||:|||||||||||||||.|:|||||||||||||||||||||
 Frog   584 GFQTITLVQCMPPAAVTAVALHSEWNLVAFGTSHGFGLFDYHRRSPVLARCTLHPNDSLAMEGPL 648

Human   651 SRVKSLKKSLRQSFRRIRKSRVSGKKRAANAS--SKLQEANAQLAEQACPHDVEMTPVQRRIEPR 713
            |||||||||||||||||||||||||||....|  |:||||||||||||.|||:::.|||||||||
 Frog   649 SRVKSLKKSLRQSFRRIRKSRVSGKKRPNTGSPPSRLQEANAQLAEQAGPHDLDIAPVQRRIEPR 713

Human   714 SADDSLSGVVRCLYFADTFLRDGAHHGPTMWAGTNSGSVFAYALEVPAAAVGGEKRPEQAVEAVL 778
            ||||||||||||||||||||||..|||||||||||||||||||||||:.    ||..:::.||||
 Frog   714 SADDSLSGVVRCLYFADTFLRDAIHHGPTMWAGTNSGSVFAYALEVPSR----EKLSDRSAEAVL 774

Human   779 GKEVQLMHRAPVVAIAVLDGRGRPLPEPYEASRDLAQAPDMQGGHAVLIASEEQFKVFTLPKVSA 843
            |||:|||||||||:||||||||.|||||:|.|:|||:||||||.|:|||:|||||||||||||||
 Frog   775 GKEIQLMHRAPVVSIAVLDGRGNPLPEPFEVSQDLAKAPDMQGTHSVLISSEEQFKVFTLPKVSA 839

Human   844 KTKFKLTAHEGCRVRKVALATFASVACEDYAETCLACLTNLGDVHVFSVPGLRPQVHYSCIRKED 908
            ||||||||||||||||||||||.|...:||:|.||||||||||:|||:||||||||.|.||||||
 Frog   840 KTKFKLTAHEGCRVRKVALATFTSATSDDYSENCLACLTNLGDIHVFTVPGLRPQVRYDCIRKED 904

Human   909 ISGIASCVFTRHGQGFYLISPSEFERFSLSARNITEPLCSLDINWPRDATQASYRIRESPKLSQA 973
            ||||||||||::|||||||||||||||||||:|||||:|.::.:.|.|....|.::..|||.:||
 Frog   905 ISGIASCVFTKYGQGFYLISPSEFERFSLSAKNITEPVCLVEFDRPHDPLHFSNKMTPSPKGNQA 969

Human   974 NGTPSIL----LAPQSLDGSPDPAHSMGPGPQVQRVLRVLVGADDLLPVDTPEPPEAALSPMSID 1034
            ||| .||    .:.|:.:|:                     |.:.:          |..||..:|
 Frog   970 NGT-HILRDSEASQQATEGN---------------------GCERM----------AEFSPSPLD 1002

Human  1035 S-ATSADTTLDTTGDVTVEDVKDFLG 1059
            | ..|.|||||||||:|||||:|.||
 Frog  1003 SPMNSMDTTLDTTGDITVEDVRDILG 1028

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LLGL1	XP_011522151.1	LLGL	280..379	CDD:285555	69/98 (70%)
llgl1	XP_002935892.2	WD40 repeat	37..69	CDD:293791	27/31 (87%)
		WD40 repeat	78..116	CDD:293791	26/37 (70%)
		LLGL	279..379	CDD:400597	69/99 (70%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	875	1.000	Domainoid score	I974
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H31220
Inparanoid	1	1.050	1540	1.000	Inparanoid score	I1328
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D113391at33208
OrthoFinder	1	1.000	-	-		FOG0000702
OrthoInspector	1	1.000	-	-		oto155447
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X453
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.060