DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jon74E and tmprss4a

DIOPT Version :9

Sequence 1:	NP_001189126.2	Gene:	Jon74E / 39959	FlyBaseID:	FBgn0023197	Length:	271	Species:	Drosophila melanogaster
Sequence 2:	XP_005157547.1	Gene:	tmprss4a / 777630	ZFINID:	ZDB-GENE-061103-631	Length:	458	Species:	Danio rerio

Alignment Length:	264	Identity:	80/264 - (30%)
Similarity:	128/264 - (48%)	Gaps:	34/264 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 SISC-LDMGHGIG-GRIAGGELARANQFPYQVGLSIEEPNDMYCWCGASLISDRYLLTAAHCV-- 78
            |:|| .|.|.... .||.||:.|....:|:||.|.....:.    ||.||::..:::|||||.
Zfish   208 SLSCSADCGLSRNQDRIVGGKDADIANWPWQVSLQYSGQHT----CGGSLVTPNWVVTAAHCFNG 268

  Fly    79 --EKAVAITYYLGGVLRLA--PRQLIRSTNPEVHLHPDWNCQSLENDIALVRLPEDALLCDSIRP 139
              .||::....:.|:..|:  |...::    |:.::.::.....:.||.:::|.....|.:|.||
Zfish   269 DGRKALSRWTVVSGITYLSSTPSSYVK----EIIVNSNYKPAESDFDITMIKLQSPITLSESRRP 329

  Fly   140 IRLPGLSSSRNSYDYVPAIASGWGRMNDESTAISDNLRYVYRFVESNEDCE----YSYANIKPTN 200
            :.||..:......|.:  :.:|||.|.::..::|..|:.....|..:..|.    |. ::|.|..
Zfish   330 VCLPPQNLGLKGGDGL--VVTGWGHMAEKGGSLSSMLQKAQIQVIDSAQCSSPTVYG-SSITPRM 391

  Fly   201 ICMDT-TGGKSTCTGDSGGPLVYSDPVQNAD--ILIGVTSYGKKSGCTK-GYPSVFTRITAYLDW 261
            ||... .||...|.||||||||:.     ||  :|:||.|:|  .||.: |:|.|:|.:...|||
Zfish   392 ICAGVMAGGVDACQGDSGGPLVHL-----ADRWVLVGVVSWG--VGCARPGFPGVYTNVDQMLDW 449

  Fly   262 IGEV 265
            ...|
Zfish   450 AHSV 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jon74E	NP_001189126.2	Tryp_SPc	31..262	CDD:214473	73/244 (30%)
tmprss4a	XP_005157547.1	LDLa	74..105	CDD:238060
		SRCR_2	121..218	CDD:295335	5/9 (56%)
		Tryp_SPc	223..449	CDD:214473	72/243 (30%)
		Tryp_SPc	224..449	CDD:238113	71/242 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910