DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jon74E and Tmprss6

DIOPT Version :9

Sequence 1:	NP_001189126.2	Gene:	Jon74E / 39959	FlyBaseID:	FBgn0023197	Length:	271	Species:	Drosophila melanogaster
Sequence 2:	NP_082178.2	Gene:	Tmprss6 / 71753	MGIID:	1919003	Length:	811	Species:	Mus musculus

Alignment Length:	263	Identity:	82/263 - (31%)
Similarity:	127/263 - (48%)	Gaps:	40/263 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 DMG-HGIGGRIAGGELARANQFPYQVGLSIEEPNDMYCWCGASLISDRYLLTAAHCV-EKAVAI- 84
            |.| .|:..||.||.::...::|:|..|.|...:    .||.:||:||:::|||||. |.::|.
Mouse   567 DCGLQGLSSRIVGGTVSSEGEWPWQASLQIRGRH----ICGGALIADRWVITAAHCFQEDSMASP 627

  Fly    85 ---TYYLGGVLRLAPRQLIRSTN------PEVHLHPDWNCQSLENDIALVRLPEDALLCDSIRPI 140
               |.:||.:     ||..|...      ..:.|||.....|.:.|:||::|....:...::||:
Mouse   628 KLWTVFLGKM-----RQNSRWPGEVSFKVSRLFLHPYHEEDSHDYDVALLQLDHPVVYSATVRPV 687

  Fly   141 RLPGLSSSRNSYDYVP---AIASGWGRMNDESTAISDNLRYVYRFVESNEDCEYSYA-NIKPTNI 201
            .||.     .|:.:.|   ...:|||... |...:|:.|:.|...:...:.|..:|. .:.|..:
Mouse   688 CLPA-----RSHFFEPGQHCWITGWGAQR-EGGPVSNTLQKVDVQLVPQDLCSEAYRYQVSPRML 746

  Fly   202 CMD-TTGGKSTCTGDSGGPLVYSDPVQNADILIGVTSYGKKSGCTKGYPS---VFTRITAYLDWI 262
            |.. ..|.|..|.||||||||..:| .....|.|:.|:|  .||  |.|:   |:||:|..::||
Mouse   747 CAGYRKGKKDACQGDSGGPLVCREP-SGRWFLAGLVSWG--LGC--GRPNFFGVYTRVTRVINWI 806

  Fly   263 GEV 265
            .:|
Mouse   807 QQV 809

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jon74E	NP_001189126.2	Tryp_SPc	31..262	CDD:214473	76/249 (31%)
Tmprss6	NP_082178.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..48
		SEA	88..185	CDD:279699
		LDLa	459..489	CDD:238060
		LDLa	495..525	CDD:238060
		Ldl_recept_a	529..566	CDD:278486
		Tryp_SPc	576..806	CDD:214473	76/249 (31%)
		Tryp_SPc	577..809	CDD:238113	77/251 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433637at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920