DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jon74E and tmprss5

DIOPT Version :9

Sequence 1:	NP_001189126.2	Gene:	Jon74E / 39959	FlyBaseID:	FBgn0023197	Length:	271	Species:	Drosophila melanogaster
Sequence 2:	XP_009289870.1	Gene:	tmprss5 / 569688	ZFINID:	ZDB-GENE-131121-184	Length:	551	Species:	Danio rerio

Alignment Length:	261	Identity:	79/261 - (30%)
Similarity:	125/261 - (47%)	Gaps:	50/261 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 RIAGGELARANQFPYQVGLSIEEPNDMYCWCGASLISDRYLLTAAHCVEK------------AVA 83
            ||.||..|...::|:||.|..   |:.:. ||.|:|::::::||||||..            |..
Zfish   311 RIIGGVEAALGRWPWQVSLYY---NNRHI-CGGSIITNQWIVTAAHCVHNYRLPQVPSWVVYAGI 371

  Fly    84 ITYYLGGVLR---LAPRQLIRSTNPEVHLHPDWNCQSLENDIALVRLPEDALLCDSIRPIRLPGL 145
            ||..|..:.:   .|..::|.:.|        :|.::.:||||||:|.......|:|||:.||
Zfish   372 ITSNLAKLAQYQGFAVERIIYNKN--------YNHRTHDNDIALVKLKTPLNFSDTIRPVCLP-- 426

  Fly   146 SSSRNSYDY-----VPAIASGWGRMNDESTAISDNLRY----VYRFVESNEDCEYSYANIKPTNI 201
                 .||:     .....||||....:...|.:.|:.    :....:.|..|.|: ..|....:
Zfish   427 -----QYDHDLPGGTQCWISGWGYTQPDDVLIPEVLKEAPVPLISTKKCNSSCMYN-GEITSRML 485

  Fly   202 CMDTTGGK-STCTGDSGGPLVYSDPVQNADILIGVTSYGKKSGCTK-GYPSVFTRITAYLDWIGE 264
            |...:.|| ..|.||||||||..|  :|...|:||.|:|  :||.: .:|.|::::..:|.||.:
Zfish   486 CAGYSEGKVDACQGDSGGPLVCQD--ENVWRLVGVVSWG--TGCAEPNHPGVYSKVAEFLGWIYD 546

  Fly   265 V 265
            :
Zfish   547 I 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jon74E	NP_001189126.2	Tryp_SPc	31..262	CDD:214473	77/256 (30%)
tmprss5	XP_009289870.1	SRCR_2	211..306	CDD:292133
		Tryp_SPc	311..544	CDD:214473	77/256 (30%)
		Tryp_SPc	312..547	CDD:238113	78/258 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433637at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920