DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jon74E and MASP1

DIOPT Version :9

Sequence 1:	NP_001189126.2	Gene:	Jon74E / 39959	FlyBaseID:	FBgn0023197	Length:	271	Species:	Drosophila melanogaster
Sequence 2:	XP_011511291.1	Gene:	MASP1 / 5648	HGNCID:	6901	Length:	735	Species:	Homo sapiens

Alignment Length:	304	Identity:	92/304 - (30%)
Similarity:	138/304 - (45%)	Gaps:	59/304 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VQGRSI-SCL-DMGH------GIGGRIAGGELARANQFPYQVGLSIEE----PNDMYCWCGASLI 66
            |.|||: :|| :.|.      .:..||.||..|....||:|..:.:|:    |||.:...|| |:
Human   431 VLGRSLPTCLPECGQPSRSLPSLVKRIIGGRNAEPGLFPWQALIVVEDTSRVPNDKWFGSGA-LL 494

  Fly    67 SDRYLLTAAHCVE-----------KAVAITYYLG--------GVLRLAPRQLIRSTNPEVHLHPD 112
            |..::|||||.:.           ....:|.|||        |.        :.|:...|.||||
Human   495 SASWILTAAHVLRSQRRDTTVIPVSKEHVTVYLGLHDVRDKSGA--------VNSSAARVVLHPD 551

  Fly   113 WNCQSLENDIALVRLPEDALLCDSIRPIRLPGLSSSRNSYDYVPAIASGWGRMNDEST------- 170
            :|.|:..:|||||:|.|...|...:.|:.||.| .......::..:.:|||..|...|
Human   552 FNIQNYNHDIALVQLQEPVPLGPHVMPVCLPRL-EPEGPAPHMLGLVAGWGISNPNVTVDEIISS 615

  Fly   171 ---AISDNLRYVYRFVESNEDCEYSYA------NIKPTNICMD-TTGGKSTCTGDSGGPLVYSDP 225
               .:||.|:||...|..:.:|:.||.      ::.....|.. ..|||.||.|||||..|..|.
Human   616 GTRTLSDVLQYVKLPVVPHAECKTSYESRSGNYSVTENMFCAGYYEGGKDTCLGDSGGAFVIFDD 680

  Fly   226 VQNADILIGVTSYGKKSGC-TKGYPSVFTRITAYLDWIGEVSGV 268
            :....::.|:.|:|....| :|....|:|:::.|:||:.|..|:
Human   681 LSQRWVVQGLVSWGGPEECGSKQVYGVYTKVSNYVDWVWEQMGL 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jon74E	NP_001189126.2	Tryp_SPc	31..262	CDD:214473	82/271 (30%)
MASP1	XP_011511291.1	CUB	35..144	CDD:238001
		FXa_inhibition	160..188	CDD:291342
		CUB	192..301	CDD:278839
		Sushi	308..369	CDD:278512
		CCP	374..439	CDD:153056	4/7 (57%)
		Tryp_SPc	456..718	CDD:214473	82/271 (30%)
		Tryp_SPc	457..718	CDD:238113	81/270 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910