DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jon74E and ACR

DIOPT Version :9

Sequence 1:	NP_001189126.2	Gene:	Jon74E / 39959	FlyBaseID:	FBgn0023197	Length:	271	Species:	Drosophila melanogaster
Sequence 2:	NP_001088.2	Gene:	ACR / 49	HGNCID:	126	Length:	421	Species:	Homo sapiens

Alignment Length:	300	Identity:	90/300 - (30%)
Similarity:	136/300 - (45%)	Gaps:	52/300 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 STILVFLLILVQGRSISCLDMGHGI--------GGRIAGGELARANQFPYQVGLSIEEPND-MYC 59
            :.||:.|.:.|..:..:..|...|:        |.||.||:.|:...:|:.|.|.|...|. .|.
Human     7 TAILLVLAVSVVAKDNATCDGPCGLRFRQNPQGGVRIVGGKAAQHGAWPWMVSLQIFTYNSHRYH 71

  Fly    60 WCGASLISDRYLLTAAHC------------VEKAVAITYYLGGVLRLAPRQLIRSTNPEVHLHPD 112
            .||.||::.|::||||||            |..|..|||.....:: ||.|  .....::.:|..
Human    72 TCGGSLLNSRWVLTAAHCFVGKNNVHDWRLVFGAKEITYGNNKPVK-APLQ--ERYVEKIIIHEK 133

  Fly   113 WNCQSLENDIALVRLPEDALLCDSIRPIRLP----GLSSSRNSYDYVPAIASGWGRMNDESTAIS 173
            :|..:..||||||.:.........|.|..||    ||.....|     ...:|||.:.:::...|
Human   134 YNSATEGNDIALVEITPPISCGRFIGPGCLPHFKAGLPRGSQS-----CWVAGWGYIEEKAPRPS 193

  Fly   174 DNLRYVYRFVESNED------C---EYSYANIKPTNICMDTTGGK-STCTGDSGGPLVYSDPVQN 228
            ..|      :|:..|      |   ::....::|||:|.....|| .||.|||||||:..|..::
Human   194 SIL------MEARVDLIDLDLCNSTQWYNGRVQPTNVCAGYPVGKIDTCQGDSGGPLMCKDSKES 252

  Fly   229 ADILIGVTSYGKKSGCTKG-YPSVFTRITAYLDWIGEVSG 267
            |.:::|:||:|  .||.:. .|.::|....||:||....|
Human   253 AYVVVGITSWG--VGCARAKRPGIYTATWPYLNWIASKIG 290

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jon74E	NP_001189126.2	Tryp_SPc	31..262	CDD:214473	80/258 (31%)
ACR	NP_001088.2	Tryp_SPc	42..285	CDD:214473	80/258 (31%)
		Tryp_SPc	43..288	CDD:238113	81/260 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..316
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	327..383
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..421
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910