DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jon74E and TMPRSS7

DIOPT Version :9

Sequence 1:	NP_001189126.2	Gene:	Jon74E / 39959	FlyBaseID:	FBgn0023197	Length:	271	Species:	Drosophila melanogaster
Sequence 2:	NP_001382436.1	Gene:	TMPRSS7 / 344805	HGNCID:	30846	Length:	843	Species:	Homo sapiens

Alignment Length:	262	Identity:	78/262 - (29%)
Similarity:	117/262 - (44%)	Gaps:	40/262 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 RSISCLDMGHGIGGRIAGGELARANQFPYQVGLSIEEPNDMYCWCGASLISDRYLLTAAHC---- 77
            ||.|.|.       ||.||.......:|:||.|.....    .:||||:||..:||:||||
Human   598 RSSSALH-------RIIGGTDTLEGGWPWQVSLHFVGS----AYCGASVISREWLLSAAHCFHGN 651

  Fly    78 -VEKAVAITYYLGGVLR-----LAP-RQLIRSTNPEVHLHPDWNCQSLENDIALVRL----PEDA 131
             :......|.:||..::     ::| |:::        :|..:|.|:.:.||||::|    ||
Human   652 RLSDPTPWTAHLGMYVQGNAKFVSPVRRIV--------VHEYYNSQTFDYDIALLQLSIAWPE-- 706

  Fly   132 LLCDSIRPIRLPGLSSSRNSYDYVPAIASGWGRMNDESTAISDNLRYVYRFVESNEDCEYSYANI 196
            .|...|:||.:|.......|.:  ....:||||.::.....|..|:.....:.....|..:|..|
Human   707 TLKQLIQPICIPPTGQRVRSGE--KCWVTGWGRRHEADNKGSLVLQQAEVELIDQTLCVSTYGII 769

  Fly   197 KPTNICMDTTGGK-STCTGDSGGPLVYSDPVQNADILIGVTSYGKKSGCTKGYPSVFTRITAYLD 260
            ....:|.....|| ..|.|||||||..........||.|:.|:|..|| ...:|.|:||::.::.
Human   770 TSRMLCAGIMSGKRDACKGDSGGPLSCRRKSDGKWILTGIVSWGHGSG-RPNFPGVYTRVSNFVP 833

  Fly   261 WI 262
            ||
Human   834 WI 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jon74E	NP_001189126.2	Tryp_SPc	31..262	CDD:214473	72/246 (29%)
TMPRSS7	NP_001382436.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	27..67
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433637at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010