DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jon74E and Tmprss6

DIOPT Version :9

Sequence 1:	NP_001189126.2	Gene:	Jon74E / 39959	FlyBaseID:	FBgn0023197	Length:	271	Species:	Drosophila melanogaster
Sequence 2:	XP_006242057.1	Gene:	Tmprss6 / 315388	RGDID:	1307138	Length:	811	Species:	Rattus norvegicus

Alignment Length:	263	Identity:	81/263 - (30%)
Similarity:	124/263 - (47%)	Gaps:	40/263 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 DMG-HGIGGRIAGGELARANQFPYQVGLSIEEPNDMYCWCGASLISDRYLLTAAHCV-EKAVAI- 84
            |.| .|...||.||.::...::|:|..|.|...:    .||.:||:||:::|||||. |.::|.
  Rat   567 DCGLQGPSSRIVGGAMSSEGEWPWQASLQIRGRH----ICGGALIADRWVITAAHCFQEDSMASP 627

  Fly    85 ---TYYLGGVLRLAPRQLIRSTN------PEVHLHPDWNCQSLENDIALVRLPEDALLCDSIRPI 140
               |.:||.:     ||..|...      ..:.|||.....|.:.|:||::|....:...::||:
  Rat   628 RLWTVFLGKM-----RQNSRWPGEVSFKVSRLFLHPYHEEDSHDYDVALLQLDHPVVYSATVRPV 687

  Fly   141 RLPGLSSSRNSYDYVP---AIASGWGRMNDESTAISDNLRYVYRFVESNEDCEYSYA-NIKPTNI 201
            .||.     .|:.:.|   ...:|||...:.... |..|:.|...:...:.|..:|. .:.|..:
  Rat   688 CLPA-----RSHFFEPGQHCWITGWGAQREGGPG-SSTLQKVDVQLIPQDLCNEAYRYQVTPRML 746

  Fly   202 CMD-TTGGKSTCTGDSGGPLVYSDPVQNADILIGVTSYGKKSGCTKGYPS---VFTRITAYLDWI 262
            |.. ..|.|..|.||||||||..:| .....|.|:.|:|  .||  |.|:   |:||:|..::||
  Rat   747 CAGYRKGKKDACQGDSGGPLVCKEP-SGRWFLAGLVSWG--LGC--GRPNFFGVYTRVTRVVNWI 806

  Fly   263 GEV 265
            .:|
  Rat   807 QQV 809

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jon74E	NP_001189126.2	Tryp_SPc	31..262	CDD:214473	75/249 (30%)
Tmprss6	XP_006242057.1	SEA	88..185	CDD:279699
		LDLa	459..489	CDD:238060
		LDLa	495..525	CDD:238060
		Ldl_recept_a	529..566	CDD:278486
		Tryp_SPc	576..806	CDD:214473	75/249 (30%)
		Tryp_SPc	577..809	CDD:238113	76/251 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433637at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920