Protein Alignment Jon74E and GZMH

DIOPT Version :10

• Sequence 1: NP_001189126.2
• Gene: Jon74E / 39959
• FlyBaseID: FBgn0023197
• Length: 271
• Species: Drosophila melanogaster
• Sequence 2: NP_219491.1
• Gene: GZMH / 2999
• HGNCID: 4710
• Length: 246
• Species: Homo sapiens
• Alignment Length: 280
• Identity: 83/280 - (29%)
• Similarity: 124/280 - (44%)
• Gaps: 70/280 - (25%)

  Fly     9 FLLILVQGRSISCLDMGHGIGGRIAGGELARANQFPYQVGLS-IEEPNDMYCWCGASLISDRYLL 72
            |||:|.     ..|..|.|. ..|.||..|:.:..||...:. ::|.:...  ||..|:...::|
Human     4 FLLLLA-----FLLTPGAGT-EEIIGGHEAKPHSRPYMAFVQFLQEKSRKR--CGGILVRKDFVL 60

  Fly    73 TAAHCVEKAVAITYYLGG--------------VLRLAPRQLIRSTNPEVHLHPDWNCQSLENDIA 123
            |||||...::.:|  ||.              |.|..|             ||.:|.::..|||.
Human    61 TAAHCQGSSINVT--LGAHNIKEQERTQQFIPVKRPIP-------------HPAYNPKNFSNDIM 110

  Fly   124 LVRLPEDALLCDSIRPIRLPGLSSSRNSYDYVPAIASGWGRMNDESTAISDNLRYVYRFVESNED 188
            |::|...|....::||:|||. |.::.....:.::| |||.::  .:.::..|:.|...|:.:..
Human   111 LLQLERKAKWTTAVRPLRLPS-SKAQVKPGQLCSVA-GWGYVS--MSTLATTLQEVLLTVQKDCQ 171

  Fly   189 CE------YSYANIKPTNICM-----DTTGGKSTCTGDSGGPLVYSDPVQNADILIGVTSYGKKS 242
            ||      ||.|    |.||:     ..||.|    ||||||||..|..|      |:.|||.|.
Human   172 CERLFHGNYSRA----TEICVGDPKKTQTGFK----GDSGGPLVCKDVAQ------GILSYGNKK 222

  Fly   243 GCTKGYPSVFTRITAYLDWI 262
            |..   |.|:.:::.:|.||
Human   223 GTP---PGVYIKVSHFLPWI 239

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jon74E	NP_001189126.2	Tryp_SPc	31..262	CDD:214473	74/256 (29%)
GZMH	NP_219491.1	Tryp_SPc	21..242	CDD:238113	76/257 (30%)
		Mediates the preference for acidic residues at the P3' and P4' sites	46..48		0/1 (0%)