Protein Alignment Jon74E and KLK5

DIOPT Version :10

• Sequence 1: NP_001189126.2
• Gene: Jon74E / 39959
• FlyBaseID: FBgn0023197
• Length: 271
• Species: Drosophila melanogaster
• Sequence 2: NP_036559.1
• Gene: KLK5 / 25818
• HGNCID: 6366
• Length: 293
• Species: Homo sapiens
• Alignment Length: 299
• Identity: 78/299 - (26%)
• Similarity: 120/299 - (40%)
• Gaps: 55/299 - (18%)

  Fly     1 MQISTILVFLLIL------VQGRSISC------------LDMGHGIG---------GRIAGGELA 38
            |.:...|:..|:|      :....:||            .|:|.|.|         .||..|...
Human     9 MWVLCALITALLLGVTEHVLANNDVSCDHPSNTVPSGSNQDLGAGAGEDARSDDSSSRIINGSDC 73

  Fly    39 RANQFPYQVGLSIEEPNDMYCWCGASLISDRYLLTAAHCVEKAVAITYYLGGVLRLAP-----RQ 98
            ..:..|:|..|.: .||.:|  |||.|:..::|||||||.:|...:..   |...|:|     :|
Human    74 DMHTQPWQAALLL-RPNQLY--CGAVLVHPQWLLTAAHCRKKVFRVRL---GHYSLSPVYESGQQ 132

  Fly    99 LIRSTN--PEVHLHPDWNCQSLENDIALVRLPEDALLCDSIRPIRLPGLSSSRNSYDYVPAIASG 161
            :.:...  |    ||.::.....||:.|::|.........:|||.:.....|..:    ..:.||
Human   133 MFQGVKSIP----HPGYSHPGHSNDLMLIKLNRRIRPTKDVRPINVSSHCPSAGT----KCLVSG 189

  Fly   162 WGRMNDESTAISDNLRYVYRFVESNEDCEYSY-ANIKPTNICMDTTGGKSTCTGDSGGPLVYSDP 225
            ||............|:.:...|.|.:.||.:| ..|..|..|.....|:.:|.||||||:|.:..
Human   190 WGTTKSPQVHFPKVLQCLNISVLSQKRCEDAYPRQIDDTMFCAGDKAGRDSCQGDSGGPVVCNGS 254

  Fly   226 VQNADILIGVTSYGKKSGCTKGYPSVFTRITAYLDWIGE 264
            :|      |:.|:|.........|.|:|.:..:..||.|
Human   255 LQ------GLVSWGDYPCARPNRPGVYTNLCKFTKWIQE 287

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jon74E	NP_001189126.2	Tryp_SPc	31..262	CDD:214473	65/238 (27%)
KLK5	NP_036559.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	37..68		5/30 (17%)
		Tryp_SPc	66..285	CDD:214473	65/238 (27%)