DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jon74E and PRSS55

DIOPT Version :9

Sequence 1:	NP_001189126.2	Gene:	Jon74E / 39959	FlyBaseID:	FBgn0023197	Length:	271	Species:	Drosophila melanogaster
Sequence 2:	NP_940866.2	Gene:	PRSS55 / 203074	HGNCID:	30824	Length:	352	Species:	Homo sapiens

Alignment Length:	249	Identity:	73/249 - (29%)
Similarity:	115/249 - (46%)	Gaps:	29/249 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 RIAGGELARANQFPYQVGLSI-EEPNDMYCWCGASLISDRYLLTAAHCVEKAVAITYYLGGVL-- 92
            ||.||..|...:||:||.:.. .||     :||.|:::..::||||||:.........|..||
Human    67 RITGGMEAEVGEFPWQVSIQARSEP-----FCGGSILNKWWILTAAHCLYSEELFPEELSVVLGT 126

  Fly    93 --RLAPRQLIRSTNPEVHLHPDWNCQSLENDIALVRLPEDALLCDSIRPIRL---PGLSSSRNSY 152
              ..:|...|:.. ..:.||.|:...:::|||||:.|.....|.|...||.|   ||.::.|..:
Human   127 NDLTSPSMEIKEV-ASIILHKDFKRANMDNDIALLLLASPIKLDDLKVPICLPTQPGPATWRECW 190

  Fly   153 DYVPAIASGWGRMN-DESTAISDNLRYVYRFVESNEDCEYSYANIKPTNICMDTTGGKS----TC 212
                  .:|||:.| .:..::..:|......:...|:|...:..:....:|   .|.|:    .|
Human   191 ------VAGWGQTNAADKNSVKTDLMKAPMVIMDWEECSKMFPKLTKNMLC---AGYKNESYDAC 246

  Fly   213 TGDSGGPLVYSDPVQNADILIGVTSYGKKSGCTKGYPSVFTRITAYLDWIGEVS 266
            .||||||||.:.........:|:.|:||..| .|..|.::|.:..|..||.:|:
Human   247 KGDSGGPLVCTPEPGEKWYQVGIISWGKSCG-EKNTPGIYTSLVNYNLWIEKVT 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jon74E	NP_001189126.2	Tryp_SPc	31..262	CDD:214473	70/243 (29%)
PRSS55	NP_940866.2	Tryp_SPc	67..295	CDD:214473	70/243 (29%)
		Tryp_SPc	68..298	CDD:238113	71/245 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	308..330
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910