DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jon74E and corin

DIOPT Version :9

Sequence 1:	NP_001189126.2	Gene:	Jon74E / 39959	FlyBaseID:	FBgn0023197	Length:	271	Species:	Drosophila melanogaster
Sequence 2:	XP_004911266.2	Gene:	corin / 100492163	XenbaseID:	XB-GENE-950958	Length:	1123	Species:	Xenopus tropicalis

Alignment Length:	294	Identity:	83/294 - (28%)
Similarity:	137/294 - (46%)	Gaps:	60/294 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ILVQG------RSISCL----DMGH----GIGGRIAGGELARANQFPYQVGLSIEEPNDMYCWCG 62
            :|::|      |.:|.|    |.|.    .:..||.||..:|..::|:|..|..:....:   ||
Frog   849 LLIKGQPCESRRKVSLLCTKEDCGRRPAARMSKRILGGRTSRPGRWPWQCSLQSDPSGHI---CG 910

  Fly    63 ASLISDRYLLTAAHCVE--KAVAITYYLGGVLRL------APRQLIRSTNPEVHLHPDWNCQSLE 119
            ..||..:::||.|||.|  ::.|:...:.|:..|      |..:|::    ::.|||.:|...::
Frog   911 CVLIGKKWVLTVAHCFEGRESAAVWKVVFGINNLDHPSDFAQTRLVK----KIILHPRYNRAVVD 971

  Fly   120 NDIALVRLPEDALLCDSIRPIRLP--GLSSSRNSYDYVPAIASGWGRMNDESTAISDNLRYVYRF 182
            .||::|.|.||......:||:.||  |.....::|.|:    :|||.|.:         :..::.
Frog   972 YDISIVELNEDITETSYVRPVCLPTKGQLVEPDTYCYI----TGWGHMGN---------KMPFKL 1023

  Fly   183 VE------SNEDCEYSYANIKPTNICMDTTGGKS----TCTGDSGGPLVYSDPVQNADILIGVTS 237
            .|      |.|.|: ||.::|.....|...|.:|    :|.||||||||...| .....|.|:||
Frog  1024 QEGEVRIISLERCQ-SYFDMKTITSRMLCAGYESGTIDSCMGDSGGPLVCEKP-GGKWTLYGLTS 1086

  Fly   238 YGKKSGCTKGY--PSVFTRITAYLDWIGEVSGVH 269
            :|  |.|....  |.|::.::.:::||.....:|
Frog  1087 WG--SVCFSKVLGPGVYSNVSHFVEWIERQIYIH 1118

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jon74E	NP_001189126.2	Tryp_SPc	31..262	CDD:214473	73/252 (29%)
corin	XP_004911266.2	CRD_corin_1	213..341	CDD:143554
		LDLa	351..382	CDD:238060
		LDLa	384..418	CDD:238060
		LDLa	420..455	CDD:238060
		LDLa	465..492	CDD:238060
		CRD_corin_2	533..654	CDD:143579
		LDLa	659..693	CDD:238060
		LDLa	734..768	CDD:238060
		Tryp_SPc	883..1114	CDD:238113	74/254 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910