DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jon74E and tmprss6

DIOPT Version :9

Sequence 1:	NP_001189126.2	Gene:	Jon74E / 39959	FlyBaseID:	FBgn0023197	Length:	271	Species:	Drosophila melanogaster
Sequence 2:	XP_004913946.2	Gene:	tmprss6 / 100489045	XenbaseID:	XB-GENE-1011573	Length:	806	Species:	Xenopus tropicalis

Alignment Length:	262	Identity:	82/262 - (31%)
Similarity:	125/262 - (47%)	Gaps:	46/262 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 IGGRIAGGELARANQFPYQVGLSIEEPNDMYCWCGASLISDRYLLTAAHC-VEKAVAI----TYY 87
            :|.|:.||..|:..::|:|..|.:...:    .||.:|::|:::|||||| ..::.|.    |.|
Frog   567 VGIRLVGGTQAQEGEWPWQASLQVRGEH----ICGGTLVADQWILTAAHCFTPESYASPEVWTVY 627

  Fly    88 LGGVLRLAPRQLIRSTNPEVH-------LHPDWNCQSLENDIALVRLPE-DALLCDSIRPIRLPG 144
            ||.|      :|.|||..|:.       :||.::..|.:.|:|||.|.. ..|....::||.||
Frog   628 LGKV------RLSRSTQKELAFKVIRLVIHPFYDEDSHDYDVALVLLDHLVPLTSPHVQPICLP- 685

  Fly   145 LSSSRNSYDYVPAIAS----GWGRMNDESTAISDNLRYVYRFVESNEDCE--YSYANIKPTNICM 203
                 :|..:.|..:|    |||.:. |:...||.|:.|...:.:.:.|.  |.| .|.|..:|.
Frog   686 -----SSTHHFPTGSSCWVTGWGSVK-ENGPTSDVLQKVDIQLVAQDICTELYRY-QISPRMLCA 743

  Fly   204 D-TTGGKSTCTGDSGGPLVYSDPVQNADILIGVTSYGKKSGCTKGYP---SVFTRITAYLDWIGE 264
            . ..|.|..|.||||.||| ...........|:.|:|  :||  |.|   .|::|||..:.||..
Frog   744 GYRDGSKDACQGDSGSPLV-CKTASGRWFQAGLVSWG--AGC--GIPRYFGVYSRITRLVQWIES 803

  Fly   265 VS 266
            ::
Frog   804 IT 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jon74E	NP_001189126.2	Tryp_SPc	31..262	CDD:214473	79/253 (31%)
tmprss6	XP_004913946.2	SEA	77..176	CDD:396113
		CUB	235..303	CDD:412131
		LDLa	448..478	CDD:238060
		LDLa	480..514	CDD:238060
		LDLa	525..560	CDD:238060
		Tryp_SPc	572..804	CDD:238113	80/254 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433637at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920