DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nedd4 and UBE3B

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	NP_569733.2	Gene:	UBE3B / 89910	HGNCID:	13478	Length:	1068	Species:	Homo sapiens

Alignment Length:	429	Identity:	137/429 - (31%)
Similarity:	213/429 - (49%)	Gaps:	51/429 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   621 QAVPYSRDYKQKYEYFKSHIRK----------PTNVPNKFEIRIRRTSILEDSYRIISSVTKTDL 675
            |.:|:...:|.:...|::.:.|          .:..|:...|.|||:.:|||.|..:..::: ..
Human   642 QYIPHVIPHKNRVLLFRTMVTKEKEKLGLVETSSASPHVTHITIRRSRMLEDGYEQLRQLSQ-HA 705

  Fly   676 LKTKLWVEFEG-----ETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQINNGSGLCN 735
            :|..:.|:|..     |.|:|..|:.:|:...:.|.:|:|...||:.::.|.....  :.:...:
Human   706 MKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDERLYP--SPTSYIH 768

  Fly   736 EEHLSYFKFIGRIAGMAVYHGKLLDAFFIRPFYKMML-------QKPIDLKDMESVDTEYYNSLM 793
            |.:|..|:|:|::.|.|||.|.::|..|...|...:|       ...:|  ::.|:|:|:|.:|.
Human   769 ENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVD--ELPSLDSEFYKNLT 831

  Fly   794 WIKENDPRI--LELTFCLDEDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQM 856
            .||..|..|  |.||...||||.||...|||.|||..|.||||||..||.|:..:|...::|.|.
Human   832 SIKRYDGDITDLGLTLSYDEDVMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQT 896

  Fly   857 SSFLDGFGSIIPLNLIKIFDEHELELLMCGIQ-NIDVKDWRENTLYKGDYHMNHIIIQWFWRAVL 920
            ::.:.||.|||....|::|...||:.|:.|.. .||::|.:::|:|.|.:|.:|.:|.|.|..:.
Human   897 AALISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILA 961

  Fly   921 S-FSNEMRSRLLQFVTGTSRVPMNGFKEL--------------------YGSNGPQMFTIEKWGT 964
            | |:.:.|:..|:|||..||.|:.||..|                    .||.....|||.|...
Human   962 SDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREP 1026

  Fly   965 PNNFPRAHTCFNRLDLPPYEGYLQLKDKLIKAIEGSQGF 1003
            ....|.:.||||.|.||.|.....|::||..||..:.||
Human  1027 GGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGF 1065

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999
		WW	248..277	CDD:278809
		WW	531..560	CDD:278809
		WW	581..613	CDD:197736
		HECTc	650..1003	CDD:238033	129/388 (33%)
		HECTc	674..1003	CDD:214523	121/364 (33%)
UBE3B	NP_569733.2	HECTc	682..1066	CDD:238033	131/389 (34%)
UBE3B	NP_569733.2	HECTc	707..1065	CDD:214523	121/361 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810