DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nedd4 and RSP5

DIOPT Version :9

Sequence 1:NP_648993.1 Gene:Nedd4 / 39958 FlyBaseID:FBgn0259174 Length:1007 Species:Drosophila melanogaster
Sequence 2:NP_011051.3 Gene:RSP5 / 856862 SGDID:S000000927 Length:809 Species:Saccharomyces cerevisiae


Alignment Length:1005 Identity:341/1005 - (33%)
Similarity:476/1005 - (47%) Gaps:276/1005 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    72 LRIVVLTGQSLAKKDIFGASDPYVRIDLNTINGDINIDSVLTKTKKKTLNPTWNEEFIFRVKPSE 136
            :.:.::..:||.|:|:|.:.||:..:   ||:|   ..:..|...||||||.|||.|.|......
Yeast     5 ISVKLVAAESLYKRDVFRSPDPFAVL---TIDG---YQTKSTSAAKKTLNPYWNETFKFDDINEN 63

  Fly   137 HKLVFQVFDENRLTRDD--FLGMVELTLVNLPTEQEGRTIG---EQSYTL--RPRRSVGAKS--- 191
            ..|..||||:.:..:.|  |||:|.:.:        |..:|   |.:.|.  |||.....:.   
Yeast    64 SILTIQVFDQKKFKKKDQGFLGVVNVRV--------GDVLGHLDEDTATSSGRPREETITRDLKK 120

  Fly   192 -----RIKGTLRIYHAFIRETREQSEPSSGN------------------------------SDGE 221
                 .:.|.|.:..:.:..:...|:..||:                              |.|.
Yeast   121 SNDGMAVSGRLIVVLSKLPSSSPHSQAPSGHTASSSTNTSSTTRTNGHSTSSTRNHSTSHPSRGT 185

  Fly   222 WEHVEATNAGETSAQPHPFPTG-------------------GHDALPAGWEERQDANGRTYYVNH 267
            .:.||:|....|:|..:...|.                   .:..||.|||.|.|..||||||:|
Yeast   186 AQAVESTLQSGTTAATNTATTSHRSTNSTSSATRQYSSFEDQYGRLPPGWERRTDNFGRTYYVDH 250

  Fly   268 TARTTQWDRPTVLNSHSSQSTDDQLASDFQRRFHISVDDTESGRSADSISHNSIEDNNNAAGLAY 332
            ..|||.|.|||:..:.:.:.......::.:||.|       .||:....|    .||::.     
Yeast   251 NTRTTTWKRPTLDQTEAERGNQLNANTELERRQH-------RGRTLPGGS----SDNSSV----- 299

  Fly   333 TPKTAATSSAPPNTPTNNNGILAQIAMQYRAEEDQDPTVDHTSFVYNSLRHPVAHRQPEISATSL 397
            |.:....|:.||     .||..|                  .:|.                    
Yeast   300 TVQVGGGSNIPP-----VNGAAA------------------AAFA-------------------- 321

  Fly   398 QNDLRPVREAPGVPDIAITNPFTRRAAGNMAGGAGWQQERRRQQMQLHIQQHQQRQQQQQQNRIL 462
                                     |.|....|.|                              
Yeast   322 -------------------------ATGGTTSGLG------------------------------ 331

  Fly   463 LDVDHRQQEPQHRGQRHQQQHRPSNEDTDHTDSHNPSDISAPSTRRNSEEDNAAVPPMEQNTGGE 527
                                                                             
Yeast   332 ----------------------------------------------------------------- 331

  Fly   528 EEPLPPRWSMQVAPNGRTFFIDHASRRTTWIDPRNG---RASPMPNQT--RRVEDDLGPLPEGWE 587
              .||..|..:..|.||.:|:||.:|.|||:|||..   |.....|.|  ::....|||||.|||
Yeast   332 --ELPSGWEQRFTPEGRAYFVDHNTRTTTWVDPRRQQYIRTYGPTNTTIQQQPVSQLGPLPSGWE 394

  Fly   588 ERVHTDGRVFYIDHNTRTTQWEDPRLSNPNIAGQAVP-YSRDYKQKYEYFKSHIRKPT--NVPNK 649
            .|:....||:::||||:||.|:||||  |:...|.|| |.||:::|..||:|   :|.  .:|.:
Yeast   395 MRLTNTARVYFVDHNTKTTTWDDPRL--PSSLDQNVPQYKRDFRRKVIYFRS---QPALRILPGQ 454

  Fly   650 FEIRIRRTSILEDSYRIISSVTKTDLLKTKLWVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGL 714
            ..|::||.:|.||:|:.|...|..| ||.:|.::|:||.||||||::||:|:|||.|||||:|.|
Yeast   455 CHIKVRRKNIFEDAYQEIMRQTPED-LKKRLMIKFDGEEGLDYGGVSREFFFLLSHEMFNPFYCL 518

  Fly   715 FEYSAMDNYTLQINNGSGLCNEEHLSYFKFIGRIAGMAVYHGKLLDAFFIRPFYKMMLQKPIDLK 779
            |||||.||||:|||..||: |.|||:|||||||:.|:.|:|.:.|||||:...|||||:|.:.|:
Yeast   519 FEYSAYDNYTIQINPNSGI-NPEHLNYFKFIGRVVGLGVFHRRFLDAFFVGALYKMMLRKKVVLQ 582

  Fly   780 DMESVDTEYYNSLMWIKEND-PRILELTFCLDEDVFGQKSQHELKPGGANIDVTNENKDEYIKLV 843
            |||.||.|.||||.|:.||. ..:|:|||..|::.||:....:|||.|.||:||:.||.||::|.
Yeast   583 DMEGVDAEVYNSLNWMLENSIDGVLDLTFSADDERFGEVVTVDLKPDGRNIEVTDGNKKEYVELY 647

  Fly   844 IEWRFVARVKEQMSSFLDGFGSIIPLNLIKIFDEHELELLMCGIQNIDVKDWRENTLYKGDYHMN 908
            .:||.|.||:||..:|:|||..:||.:|:.:|||.|||||:.||..||::||:::|.|:| |..:
Yeast   648 TQWRIVDRVQEQFKAFMDGFNELIPEDLVTVFDERELELLIGGIAEIDIEDWKKHTDYRG-YQES 711

  Fly   909 HIIIQWFWRAVLSFSNEMRSRLLQFVTGTSRVPMNGFKELYGSNGPQMFTIEKWGTPNNFPRAHT 973
            ..:|||||:.|..:.||.|:|||||.|||||:|:||||:|.||:||:.|||||.|.....|::||
Yeast   712 DEVIQWFWKCVSEWDNEQRARLLQFTTGTSRIPVNGFKDLQGSDGPRRFTIEKAGEVQQLPKSHT 776

  Fly   974 CFNRLDLPPYEGYLQLKDKLIKAIEGSQGF 1003
            ||||:|||.|..|..:|.||..|:|.:.||
Yeast   777 CFNRVDLPQYVDYDSMKQKLTLAVEETIGF 806

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nedd4NP_648993.1 C2_NEDD4_NEDD4L 71..204 CDD:175999 41/146 (28%)
WW 248..277 CDD:278809 18/28 (64%)
WW 531..560 CDD:278809 13/28 (46%)
WW 581..613 CDD:197736 18/31 (58%)
HECTc 650..1003 CDD:238033 192/353 (54%)
HECTc 674..1003 CDD:214523 183/329 (56%)
RSP5NP_011051.3 HUL4 3..809 CDD:227354 341/1005 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 353 1.000 Domainoid score I139
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H86986
Inparanoid 1 1.050 584 1.000 Inparanoid score I146
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000080
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100256
Panther 1 1.100 - - O PTHR11254
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2273
SonicParanoid 1 1.000 - - X1682
TreeFam 1 0.960 - -
1110.850

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