Protein Alignment Nedd4 and RSP5

DIOPT Version :10

• Sequence 1: NP_648993.1
• Gene: Nedd4 / 39958
• FlyBaseID: FBgn0259174
• Length: 1007
• Species: Drosophila melanogaster
• Sequence 2: NP_011051.3
• Gene: RSP5 / 856862
• SGDID: S000000927
• Length: 809
• Species: Saccharomyces cerevisiae
• Alignment Length: 1005
• Identity: 341/1005 - (33%)
• Similarity: 476/1005 - (47%)
• Gaps: 276/1005 - (27%)

  Fly    72 LRIVVLTGQSLAKKDIFGASDPYVRIDLNTINGDINIDSVLTKTKKKTLNPTWNEEFIFRVKPSE 136
            :.:.::..:||.|:|:|.:.||:..:   ||:|   ..:..|...||||||.|||.|.|......
Yeast     5 ISVKLVAAESLYKRDVFRSPDPFAVL---TIDG---YQTKSTSAAKKTLNPYWNETFKFDDINEN 63

  Fly   137 HKLVFQVFDENRLTRDD--FLGMVELTLVNLPTEQEGRTIG---EQSYTL--RPRRSVGAKS--- 191
            ..|..||||:.:..:.|  |||:|.:.:        |..:|   |.:.|.  |||.....:.
Yeast    64 SILTIQVFDQKKFKKKDQGFLGVVNVRV--------GDVLGHLDEDTATSSGRPREETITRDLKK 120

  Fly   192 -----RIKGTLRIYHAFIRETREQSEPSSGN------------------------------SDGE 221
                 .:.|.|.:..:.:..:...|:..||:                              |.|.
Yeast   121 SNDGMAVSGRLIVVLSKLPSSSPHSQAPSGHTASSSTNTSSTTRTNGHSTSSTRNHSTSHPSRGT 185

  Fly   222 WEHVEATNAGETSAQPHPFPTG-------------------GHDALPAGWEERQDANGRTYYVNH 267
            .:.||:|....|:|..:...|.                   .:..||.|||.|.|..||||||:|
Yeast   186 AQAVESTLQSGTTAATNTATTSHRSTNSTSSATRQYSSFEDQYGRLPPGWERRTDNFGRTYYVDH 250

  Fly   268 TARTTQWDRPTVLNSHSSQSTDDQLASDFQRRFHISVDDTESGRSADSISHNSIEDNNNAAGLAY 332
            ..|||.|.|||:..:.:.:.......::.:||.|       .||:....|    .||::.
Yeast   251 NTRTTTWKRPTLDQTEAERGNQLNANTELERRQH-------RGRTLPGGS----SDNSSV----- 299

  Fly   333 TPKTAATSSAPPNTPTNNNGILAQIAMQYRAEEDQDPTVDHTSFVYNSLRHPVAHRQPEISATSL 397
            |.:....|:.||     .||..|                  .:|.
Yeast   300 TVQVGGGSNIPP-----VNGAAA------------------AAFA-------------------- 321

  Fly   398 QNDLRPVREAPGVPDIAITNPFTRRAAGNMAGGAGWQQERRRQQMQLHIQQHQQRQQQQQQNRIL 462
                                     |.|....|.|
Yeast   322 -------------------------ATGGTTSGLG------------------------------ 331

  Fly   463 LDVDHRQQEPQHRGQRHQQQHRPSNEDTDHTDSHNPSDISAPSTRRNSEEDNAAVPPMEQNTGGE 527
                                                                             
Yeast   332 ----------------------------------------------------------------- 331

  Fly   528 EEPLPPRWSMQVAPNGRTFFIDHASRRTTWIDPRNG---RASPMPNQT--RRVEDDLGPLPEGWE 587
              .||..|..:..|.||.:|:||.:|.|||:|||..   |.....|.|  ::....|||||.|||
Yeast   332 --ELPSGWEQRFTPEGRAYFVDHNTRTTTWVDPRRQQYIRTYGPTNTTIQQQPVSQLGPLPSGWE 394

  Fly   588 ERVHTDGRVFYIDHNTRTTQWEDPRLSNPNIAGQAVP-YSRDYKQKYEYFKSHIRKPT--NVPNK 649
            .|:....||:::||||:||.|:||||  |:...|.|| |.||:::|..||:|   :|.  .:|.:
Yeast   395 MRLTNTARVYFVDHNTKTTTWDDPRL--PSSLDQNVPQYKRDFRRKVIYFRS---QPALRILPGQ 454

  Fly   650 FEIRIRRTSILEDSYRIISSVTKTDLLKTKLWVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGL 714
            ..|::||.:|.||:|:.|...|..| ||.:|.::|:||.||||||::||:|:|||.|||||:|.|
Yeast   455 CHIKVRRKNIFEDAYQEIMRQTPED-LKKRLMIKFDGEEGLDYGGVSREFFFLLSHEMFNPFYCL 518

  Fly   715 FEYSAMDNYTLQINNGSGLCNEEHLSYFKFIGRIAGMAVYHGKLLDAFFIRPFYKMMLQKPIDLK 779
            |||||.||||:|||..||: |.|||:|||||||:.|:.|:|.:.|||||:...|||||:|.:.|:
Yeast   519 FEYSAYDNYTIQINPNSGI-NPEHLNYFKFIGRVVGLGVFHRRFLDAFFVGALYKMMLRKKVVLQ 582

  Fly   780 DMESVDTEYYNSLMWIKEND-PRILELTFCLDEDVFGQKSQHELKPGGANIDVTNENKDEYIKLV 843
            |||.||.|.||||.|:.||. ..:|:|||..|::.||:....:|||.|.||:||:.||.||::|.
Yeast   583 DMEGVDAEVYNSLNWMLENSIDGVLDLTFSADDERFGEVVTVDLKPDGRNIEVTDGNKKEYVELY 647

  Fly   844 IEWRFVARVKEQMSSFLDGFGSIIPLNLIKIFDEHELELLMCGIQNIDVKDWRENTLYKGDYHMN 908
            .:||.|.||:||..:|:|||..:||.:|:.:|||.|||||:.||..||::||:::|.|:| |..:
Yeast   648 TQWRIVDRVQEQFKAFMDGFNELIPEDLVTVFDERELELLIGGIAEIDIEDWKKHTDYRG-YQES 711

  Fly   909 HIIIQWFWRAVLSFSNEMRSRLLQFVTGTSRVPMNGFKELYGSNGPQMFTIEKWGTPNNFPRAHT 973
            ..:|||||:.|..:.||.|:|||||.|||||:|:||||:|.||:||:.|||||.|.....|::||
Yeast   712 DEVIQWFWKCVSEWDNEQRARLLQFTTGTSRIPVNGFKDLQGSDGPRRFTIEKAGEVQQLPKSHT 776

  Fly   974 CFNRLDLPPYEGYLQLKDKLIKAIEGSQGF 1003
            ||||:|||.|..|..:|.||..|:|.:.||
Yeast   777 CFNRVDLPQYVDYDSMKQKLTLAVEETIGF 806

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999	41/146 (28%)
		WW	248..277	CDD:459800	18/28 (64%)
		HUL4	<523..1003	CDD:227354	246/488 (50%)
RSP5	NP_011051.3	HUL4	3..809	CDD:227354	341/1005 (34%)