DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nedd4 and UFD4

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	NP_012915.3	Gene:	UFD4 / 853859	SGDID:	S000001493	Length:	1483	Species:	Saccharomyces cerevisiae

Alignment Length:	404	Identity:	107/404 - (26%)
Similarity:	185/404 - (45%)	Gaps:	79/404 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   651 EIRIRRTSILEDSYRIISSV-TKTDLLKTKLWVEFEGETG------LDYGGLAREWFYLLSKEMF 708
            ::||.|.:|.....:|:|.. :..|:|:    :|::.|.|      |::..:..::|...|..|:
Yeast  1102 KLRISRKTIFATGLKILSKYGSSPDVLE----IEYQEEAGTGLGPTLEFYSVVSKYFARKSLNMW 1162

  Fly   709 N----PYYGLFEYSAMDNY--TL----QINNGSGLCNEEHLSYFKFIGRIAGMAVYHGKLLDAFF 763
            .    .|....:....|:|  ||    .:|..|.  ||:.:..|.::|.....::...::||..|
Yeast  1163 RCNSYSYRSEMDVDTTDDYITTLLFPEPLNPFSN--NEKVIELFGYLGTFVARSLLDNRILDFRF 1225

  Fly   764 IRPFYKMMLQK--------PIDLKD----MESVDTEYYNSLMWIKEN--DPRILE---LTFCL-- 809
            .:.|::::.:.        |.|::.    :|.||.....||.:|..|  |...||   |||.:
Yeast  1226 SKVFFELLHRMSTPNVTTVPSDVETCLLMIELVDPLLAKSLKYIVANKDDNMTLESLSLTFTVPG 1290

  Fly   810 DEDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIPLNLIKI 874
            ::|:       ||.|||.|..:.:.|.:|||..||:......:::|:.:|::||.        |:
Yeast  1291 NDDI-------ELIPGGCNKSLNSSNVEEYIHGVIDQILGKGIEKQLKAFIEGFS--------KV 1340

  Fly   875 FDEHELELLMCGIQNIDV-----KDWRENTLY-----KGDYHMNHIIIQWFWRAVLSFSNEMRSR 929
            | .:|..|::...:.:|:     :||...|||     :..|.|:..||..|...:.:|....|..
Yeast  1341 F-SYERMLILFPDELVDIFGRVEEDWSMATLYTNLNAEHGYTMDSSIIHDFISIISAFGKHERRL 1404

  Fly   930 LLQFVTGTSRVPMNGFKELYGSNGPQMFTI-----EKWGTPNNF-PRAHTCFNRLDLPPYEGYLQ 988
            .|||:||:.::|:.|||.|    .|: ||:     |...|.:.: |...||.|.|.||.|.....
Yeast  1405 FLQFLTGSPKLPIGGFKSL----NPK-FTVVLKHAEDGLTADEYLPSVMTCANYLKLPKYTSKDI 1464

  Fly   989 LKDKLIKAIEGSQG 1002
            ::.:|.:|||...|
Yeast  1465 MRSRLCQAIEEGAG 1478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999
		WW	248..277	CDD:278809
		WW	531..560	CDD:278809
		WW	581..613	CDD:197736
		HECTc	650..1003	CDD:238033	107/404 (26%)
		HECTc	674..1003	CDD:214523	101/380 (27%)
UFD4	NP_012915.3	HUL4	581..1482	CDD:227354	107/404 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900